Hypoglycaemia in a diabetic patient, associated with ciprofloxacin therapy

Whiteley, Miriam; Worlding, J; Patel, Sangram Singh; Gibbs, Ka

doi:10.1002/pdi.1960100116

Cited by 18 publications

(14 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical case reports of fluoroquinolone-associated dysglycemias (hyperglycemia and hypoglycemia) have involved patients treated with ciprofloxacin, [22][23][24] gatifloxacin, [25][26][27][28][29][30][31][32] and levofloxacin. 33 Most of these cases were associated specifically with gatifloxacin.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective, Comparative Evaluation of Dysglycemias in Hospitalized Patients Receiving Gatifloxacin, Levofloxacin, Ciprofloxacin, or Ceftriaxone

Mohr¹,

McKinnon²,

Peymann³

et al. 2005

Pharmacotherapy

View full text Add to dashboard Cite

In the 17,108 patients receiving a fluoroquinolone or ceftriaxone, the rate of dysglycemia was greater in those receiving levofloxacin or gatifloxacin than in those receiving ceftriaxone. However, no difference was noted in the rate of glucose abnormalities with levofloxacin versus gatifloxacin. Clinicians should be aware of dysglycemic events that may occur in patients receiving fluoroquinolones, especially in those with diabetes mellitus or those receiving sulfonylureas.

show abstract

Section: Discussionmentioning

confidence: 99%

A Retrospective, Comparative Evaluation of Dysglycemias in Hospitalized Patients Receiving Gatifloxacin, Levofloxacin, Ciprofloxacin, or Ceftriaxone

Mohr¹,

McKinnon²,

Peymann³

et al. 2005

Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…Although uncommon, hypoglycemia has been reported with all the fluoroquinolones. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Hypoglycemia typically occurs within the first 3 days of fluoroquinolone therapy and has been reported after the first dose of either intravenous or oral administration. 1,3,[17][18][19] Elderly patients with type 2 diabetes mellitus, especially those taking oral sulfonylureas, appear to be prone to this adverse event.…”

mentioning

confidence: 99%

“…Case reports have been published for ciprofloxacin and gatifloxacin. [1][2][3][4][5][6] Although none have been published for either moxifloxacin or levofloxacin, hypoglycemia has been reported in the respective new drug applica-tions and package inserts for these agents. 7,8,10,11 We report a case of fatal hypoglycemia associated with levofloxacin administration in an elderly patient with diabetes who was receiving levofloxacin for treatment of presumed aspiration pneumonia.…”

mentioning

confidence: 99%

Fatal Hypoglycemia Associated with Levofloxacin

Friedrich

Dougherty

2004

Pharmacotherapy

View full text Add to dashboard Cite

Fluoroquinolones are generally regarded as safe antimicrobial agents with relatively few adverse effects or drug interactions. Thus, they enjoy widespread use for treatment of community- and hospital-acquired infections. Although uncommon, hypoglycemia has been reported with all the fluoroquinolones and appears to occur most frequently in elderly patients with type 2 diabetes mellitus who are receiving therapy with oral hypoglycemics. The exact mechanism of this effect is unknown but is postulated to be a result of blockage of adenosine 5'-triphosphate-sensitive potassium channels in pancreatic beta-cell membranes. We report a case of fatal hypoglycemia related to levofloxacin administration in an elderly patient with diabetes. As with other fluoroquinolones, levofloxacin can cause profound and prolonged hypoglycemia. Clinicians should be cognizant of this potential adverse effect in patients with diabetes who are receiving levofloxacin therapy.

show abstract

“…Hypoglycemia is a well‐known adverse effect of gatifloxacin, 2 , 4 and it was the primary the reason for its withdrawal from the market. Hypoglycemia with other fluoroquinolones such as ciprofloxacin and levofloxacin is also reported, 1 , 3 and medical literature supports evidence for levofloxacin‐induced hypoglycemic deaths. The exact frequency of hypoglycemia associated with the fluoroquinolones is not known.…”

Section: Discussionmentioning

confidence: 92%