Hypoglycaemia in endocrine, diabetic, and internal diseases [Hipoglikemia w schorzeniach endokrynologicznych, diabetologicznych i internistycznych]

Rokicka, Dominika; Marek, Bogdan; Kajdaniuk, Dariusz; Wróbel, Marta; Szymborska-Kajanek, Aleksandra; Ogrodowczyk-Bobik, Monika; Urbanek, Agata; Janyga, Szymon; Borgiel−Marek, Halina; Strojek, Krzysztof

doi:10.5603/ep.a2019.0020

Cited by 4 publications

(3 citation statements)

References 45 publications

(129 reference statements)

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“…The major steps in the development of insulin to be administered by this route include the following: 1. purification of insulin, 2. formulation to reduce antibody formation together with allergic and injection site reactions, 3. mechanisms to delay insulin absorption allowing basal insulin coverage, and 4. changes to accelerate absorption of insulin for prandial therapy. Also, it must be remembered that insulin treatment is associated with a high risk of hypoglycaemia [9]. In order to avoid the many problems, more effective approaches for insulin delivery were developed; these included the following: 1. the first pancreas transplant in a human, performed in 1967; 2.…”

Section: Understandings About Routes Of Administrationmentioning

confidence: 99%

“…However, this significant understanding has not affected or dealt with problems of insulin therapy, such as insulin resistance. Nevertheless, while the mechanisms are not clear, the understandings around self-association to form dimers and hexamers, and where the receptor binding domain might lie, have led to the invention/production of long-acting insulin analogues and their rapid acting forms [8,9].…”

Section: Therapeutic Consequences Of Insulin Receptormentioning

confidence: 99%

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100 years of insulin: victories, hopes, and existing challenges

Pierzchała-Koziec

Scanes

2021

Endokrynologia Polska

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Section: Understandings About Routes Of Administrationmentioning

confidence: 99%

Section: Therapeutic Consequences Of Insulin Receptormentioning

confidence: 99%

100 years of insulin: victories, hopes, and existing challenges

Pierzchała-Koziec

Scanes

2021

Endokrynologia Polska

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“…Bariatric surgeries have a strong impact on the metabolism, carbohydrates, and lipid turnover as well as on the hormonal system [3,21,22].…”

Section: Figure 4 Blood Ghrelin Levels [Fmol/ml] In Females Before (mentioning

confidence: 99%

Opioid-like peptides and ghrelin mitigation of bariatric results depends on obesity level

Dyaczyński

Dróżdż

Wylężek

et al. 2020

Endokrynologia Polska

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Introduction: Bariatric surgery, as the only effective treatment of obesity, has strong effects on the metabolism, and nervous and endocrine systems. Thus, based on the different opinions about the efficaciousness of morbid obesity treatments, the aim of the present study was to estimate the association of serum ghrelin and Met-enkephalin (native, five amino acids and cryptic, precursor of enkephalin) concentrations with body mass index (BMI) value in bariatric patients within 30 postoperative days. Material and methods: The study was performed on 38 female patients divided into two groups: I -BMI lower than 40 kg/m 2 (n = 18) and II -BMI higher than 40 kg/m 2 (n = 20). Blood was taken before (-24 h), and 72 h and 30 days after the sleeve gastrectomy. Routine haematological, anthropometric, and metabolic parameters as well as thyroid-stimulating hormone (TSH), ghrelin, and Met-enkephalin values were measured in all patients. Results: There were statistically significant differences between the two groups before the surgery in terms of TSH, both forms of Metenkephalin, triglycerides concentrations, and activity of alanine transaminase (ALT), gamma-glutamyltransferase (GGTP), and C-reactive protein (CRP). After 72 h, the serum levels of cryptic Met-enkephalin and CRP, and activity of enzymes varied between the two groups of patients. Thirty days after the surgery, some metabolic and immune parameters were still different in both female groups in favour of patients with lover BMI. However, significant differences were noticed in the levels of ghrelin (increase), and native (decrease) and cryptic Met-enkephalins (increase). Conclusions: The activity of endogenous peptides in bariatric patients is connected with the degree of obesity. Ghrelin level increases are negatively correlated with native Met-enkephalin changes shortly after bariatric surgery. The interplay of ghrelin and opioids might be considered as a predictor of postoperative weight loss success. (Endokrynol Pol 2020; 71 (1): 27-33)  28 ORIGINAL PAPER Opioids and ghrelin affect bariatrics Michał Dyaczyński et al.

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Evaluation of risk factors and correlation in large sample from the perspective of hypoglycemia

Chao

Zhu

Chen

2021

Food Science & Nutrition

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Hypoglycemia is defined several types, including severe hypoglycemia, symptomatic, and asymptomatic hypoglycemia (all blood glucose ≤70 mg/dl, but the symptoms are different), which may be hypoglycemia (symptomatic, but blood glucose is unknown) and relative hypoglycemia (symptomatic but still more than 70 mg/ dl) (Smith et al., 2018). The incidence of hypoglycemia has not been significantly lower in diabetic patients with improved blood glucose management and increased use of insulin (Holt, 2019).Studies suggest that hypoglycemia is directly associated with the risk of cognitive impairment and physical weakness (Abdelhafiz & Sinclair, 2019). Stable blood glucose concentration can ensure that the right amount of carbohydrates are transported to the brain,

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Hypoglycaemia in endocrine, diabetic, and internal diseases [Hipoglikemia w schorzeniach endokrynologicznych, diabetologicznych i internistycznych]

Cited by 4 publications

References 45 publications

100 years of insulin: victories, hopes, and existing challenges

100 years of insulin: victories, hopes, and existing challenges

Opioid-like peptides and ghrelin mitigation of bariatric results depends on obesity level

Evaluation of risk factors and correlation in large sample from the perspective of hypoglycemia

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