Hypoglycaemic Activity of an HMG-Containing Flavonoid Glucoside, Chamaemeloside, from<i>Chamaemelum nobile</i>

König, Gabriele M.; Wright, Anthony D.; Keller, William J.; Judd, Robert L.; Bates, Sarah; Day, Caroline

doi:10.1055/s-2006-957532

Cited by 29 publications

(24 citation statements)

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“…Nossos resultados estão de acordo com a literatura científica, que aponta um grande número de compostos com potencial antidiabético, porém não confirmados em estudos laboratoriais 17 . Assim, embora não tenhamos obtido efeito antidiabético, nossos resultados são relevantes, considerando o amplo consumo desta planta pela população.…”

Section: Resultsunclassified

Estudo fitoquímico e avaliação do potencial antidiabético do Cissus sicyoides L. (Vitaceae)

Beltrame¹,

Sartoretto²,

Bazotte³

et al. 2001

Quím. Nova

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Recebido em 6/10/00; aceito em 8/2/01 PHYTOCHEMICAL STUDY AND EVALUATION OF THE ANTIDIABETIC POTENTIAL OF CISSUS SICYOIDES L. (VITACEAE). The effect of hydroalcoholic extracts (HE) obtained from leaves of Cissus sicyoides (CS) on glucose tolerance (GT) was investigated in rats treated with dexametasone (DEX). Our results showed that HE intensified the decreased GT promoted by (DEX). Additionally, the flavonoids kaempferol 3-O-rhamnoside and quercetin 3-O-rhamnoside, obtained from aerial parts of CS, were used to study the incorporation of glucose to glycogen in soleo muscle. The results showed that both flavonoids did not show effect on glycogen synthesis. Thus, our data, in contrast to popular believe, did not reveal antidiabetic activity to SC.Keywords: Cissus sicyoides; Vitaceae; antidiabetic potential; flavonoids. Quim. Nova, Vol. 24, No. 6, 783-785, 2001. O pó das partes aéreas (300g) foi macerado com metanol a temperatura ambiente por oito dias. Após a destilação do solvente sob temperatura reduzida, obteve-se 33,9 g do extrato metanólico (EM). Artigo INTRODUÇÃOExtração e fracionamento.

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Section: Resultsunclassified

Estudo fitoquímico e avaliação do potencial antidiabético do Cissus sicyoides L. (Vitaceae)

Beltrame¹,

Sartoretto²,

Bazotte³

et al. 2001

Quím. Nova

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“…Cn is world wildly used in the treatment of various diseases [17] . Our previous works demonstrated the potent hypoglycaemic effect of Cn aqueous extract in streptozotocin-induced diabetic rats [18] .…”

Section: Discussionmentioning

confidence: 99%

Acute Hypotensive and Diuretic Activities of Chamaemelum nobile Aqueous Extract in Normal Rats

Zeggwagh¹,

Michel²,

Eddouks³

2007

American J. of Pharmacology and Toxicology

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This study aims to evaluate the effect of Chamaemelum nobile (Cn) intravenous injection on cardiovascular and renal function of normal rats. Intravenous bolus injection of Cn at the dose of 50, 100 and 200 mg kg , produced dose dependent reduction in arterial blood pressure (p<0.001). Significant reduction in heart frequency was observed after Cn injection at a dose of 100 and 200 mg kg −1 (p<0.001). Perfusion of Cn aqueous extract at a dose of 200 mg kg −1 h −1 caused a significant increase in urine output after three hours of perfusion (p<0.001). Significant increase in urinary sodium and potassium excretion was observed from the first (p<0.05) to the third hour (p<0.001) of Cn perfusion. Urinary chlorure excretion increased after two hours of perfusion (p<0.001). However, glomerualr filtration rate remained unchanged after Cn perfusion (p<0.05). We conclude that the Cn aqueous extract possess potent acute hypotensive effect in normal rats. In addition Cn perfusion may affect renal function to increase urine and electrolytes excretion.

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“…RC is known as a medicinal plant since the middle age (16). However, the provided clinical and non-clinical data for RC do not fulfill the requirements of a well-established medicinal use with recognized efficacy (17,18). Herbal substance of RC has a small potential for sensitization and it possesses antibacterial, antifungal, anti-inflammatory, cytotoxic, brochodilatory, hypotensive, anti-platelet aggregation, antioxidant, and hypoglycemic effects (19,20).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Anti-inflammatory and Antioxidant Parameters of Aqueous and Ethanolic Extracts of Roman chamomile in mice

Erjaee¹,

Rajaian²,

Nazifi³

2018

tjps

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The injection of carrageenan in mouse paws causes inflammation and pain via enhancement of reactive oxygen species formation. In the present study, anti-inflammatory and antioxidant activities of the aqueous and ethanolic extracts of Chamaemelum nobile commonly known as Roman chamomile (RC) were assayed in carrageenan induced mice paw edema. Results showed that RC ethanolic extract is able to inhibit the development of paw edema. Moreover, oral pretreatment of RC ethanolic extract significantly decreased production of pro-inflammatory cytokines including interleukin (IL)-1 , tumor necrosis factor-(TNF-) and IL-6. RC ethanolic extract showed significant radical scavenging effect by inhibition of lipid peroxidation and increasing antioxidant enzyme activities including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). However, the elevation of these enzyme activities by RC aqueous extract was not significant. Generally, RC ethanolic extract showed better inhibitory effect on inflammation, which is similar to the effect of the anti-inflammatory drug indomethacin. Thus, it is suggested that RC possesses anti-inflammatory effect by inhibiting the proinflammatory cytokines and reducing the oxidative damage. Therefore, this plant can be one of the alternatives for treating inflammatory conditions.

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Hypoglycaemic Activity of an HMG-Containing Flavonoid Glucoside, Chamaemeloside, fromChamaemelum nobile

Abstract: The 3-hydroxy-3-methylglutaric acid (HMG) containing flavonoid glucoside chamaemeloside, has been determined to have in vivo hypoglycaemic activity comparable to that of free HMG. An improved isolation scheme for obtaining chamaemeloside from Chamaemelum nobile is presented.

Cited by 29 publications

References 1 publication

Estudo fitoquímico e avaliação do potencial antidiabético do Cissus sicyoides L. (Vitaceae)

Estudo fitoquímico e avaliação do potencial antidiabético do Cissus sicyoides L. (Vitaceae)

Acute Hypotensive and Diuretic Activities of Chamaemelum nobile Aqueous Extract in Normal Rats

Evaluation of the Anti-inflammatory and Antioxidant Parameters of Aqueous and Ethanolic Extracts of Roman chamomile in mice

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