Hypoglycaemic and antihyperglycaemic activity of &lt;i&gt;Ageratum conyzoides&lt;/i&gt; l. In rats.

Nyunaï, Nyemb; Njikam, Njifutie; Abdennebi, El Hassane; Mbafor, Joseph Tanyi; Lamnaouer, Driss

doi:10.4314/ajtcam.v6i2.57083

Cited by 23 publications

(22 citation statements)

References 17 publications

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“…The extract may inhibit glucose absorption in gut (Bhowmik et al, 2009). Alternately, the extract may potentiate the pancreatic secretion of insulin or increase the glucose uptake (Farjou et al, 1987;Nyunai et al, 2009). Although the present study did not identify the chemical component(s) responsible for the observed antihyperglycemic effect, it may be noted that quercetin is one of the components reported to be present in khoyer (Rajendra et al, 2011).…”

Section: Resultscontrasting

confidence: 48%

Antihyperglycemic and antinociceptive activity evaluation of ‘Khoyer’ prepared from boiling the wood of <i>Acacia catechu</i> in water

Rahmatullah

Hossain

Mahmud

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Abstract'Khoyer' is prepared by boiling the wood of Acacia catechu in water and then evaporating the resultant brew. The resultant hard material is powdered and chewed with betel leaves and lime with or without tobacco by a large number of the people of Bangladesh as an addictive psycho-stimulating and euphoria-inducing formulation. There are folk medicinal claims that khoyer helps in the relief of pain and is also useful to diabetic patients to maintain normal sugar levels. Thus far no scientific studies have evaluated the antihyperglycemic and antinociceptive effects of khoyer. The present study was carried out to evaluate the possible glucose tolerance efficacy of methanolic extracts of khoyer using glucose-induced hyperglycemic mice, and antinociceptive effects with acetic acid-induced gastric pain models in mice. In antihyperglycemic activity tests, the extract at different doses was administered one hour prior to glucose administration and blood glucose level was measured after two hours of glucose administration (p.o.) using glucose oxidase method. The statistical data indicated the significant oral hypoglycemic activity on glucose-loaded mice at all doses of the extracts tested. Maximum anti-hyperglycemic activity was shown at 400 mg extract per kg body weight, which was less than that of a standard drug, glibenclamide (10 mg/kg body weight). In antinociceptive activity tests, the extract also demonstrated a dose-dependent significant reduction in the number of writhing induced in mice through intraperitoneal administration of acetic acid. Maximum antinociceptive activity was observed at a dose of 400 mg extract per kg body weight, which was greater than that of a standard antinociceptive drug, aspirin, when administered at a dose of 400 mg per kg body weight. The results validate the folk medicinal use of the plant for reduction of blood sugar in diabetic patients, as well as the folk medicinal use for alleviation of pain.

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Section: Resultscontrasting

confidence: 48%

Antihyperglycemic and antinociceptive activity evaluation of ‘Khoyer’ prepared from boiling the wood of <i>Acacia catechu</i> in water

Rahmatullah

Hossain

Mahmud

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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“…Reduction of serum glucose levels of ethanolic extract by several factors. The extract of bottle gourd may influence in a positive manner the pancreatic secretion of insulin, or the extract may increase the glucose uptake [18], thus reducing the presence of glucose in serum.…”

Section: Anti-hyperglycemic Activity Of Ethanolic Extractmentioning

confidence: 99%

Antioxidant Activity and Anti-Hyperglycemic Effect of Lagenaria Siceraria Fruit Extract

Luan¹,

Hong²

2016

JFSE

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Lagenaria siceraria (Molina) Standl., known as bottle gourd is widely available throughout Vietnam as an edible vegetable. Bottle gourd is a commonly fruit but there are little reports about its biological activities. The aim of the present study was to evaluate antioxidant activity and anti-hyperglycemic potential of ethanolic extract of bottle gourd. The ethanolic extract was tested for its antioxidant activity on chelating power, the ferric reducing/antioxidant power assay (FRAP) and the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay. The results showed that chelating activity was 80.02%, FRAP value was 92.84 μmol Fe 2+ /g and active radical scavenging which showed an IC 50 was 49.50 µg/ml. The five different doses of ethanolic extract were treated by oral tolerance to mice body before oral glucose tolerance and blood glucose level was measured using glucose oxidase method. The result indicated that inhibition percentage of ethanolic extract of bottle gourd at the dose of 400 mg/kg in glucose-induced hyperglycemic mice was effectively similar to standard drug glibenclamide. The results obtained indicate that ethanolic extract from bottle gourd is the potential antioxidant and anti-hyperglycemic agent.

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“…Rats were divided in to four groups (n = 6) were administered with distilled water (10 ml/kg), Glibenclamide (standard drug) (10 mg/kg) 10 , and ethanolic extracts (PIELE) at dose of 100 and 200 mg/kg p.o. by help of oral gavages, respectively.…”

Section: Oral Glucose Tolerance Test (Ogtt)mentioning

confidence: 99%

“…Blood glucose levels were measured by withdrawing a drop of blood from tip of the animal tail and placing it on the glucometer strip 10 . The accu-check glucometer with the help of strips gives the digital value of blood glucose level.…”

Section: Preparation Of Drug Solutionmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The worldwide prevalence of diabetes mellitus (DM) has risen dramatically over the past two decades; based on current trends, more than 360 million individuals will be having diabetes by year 2030. The present study was designed to investigate the hypoglycemic of effect of ethanolic extract of leaves of Passiflora insarnata linn. in streptozotocin-induced diabetes in rat. The pharmacological investigation suggested that the ethanolic extract of the leaves was beneficial in controlling the blood glucose levels, improves the lipid metabolism and prevents diabetic complications from lipid peroxidation in experimental diabetic rats. From this study, it can be concluded that the ethanolic extract of the plant exhibited protective and ameliorative effects against streptozotocin induced pancreatic cytotoxicity and severe hyperglycaemia by enhancing the peripheral utilization of glucose, correcting the impaired liver glycolysis and limiting gluconeogenic formation and also repairing and rejuvenating the residual beta cell population. These effects may be due to the presence of phenolic compounds, flavonoids, and other phytochemical constituents, which could act synergistically or independently in modulating the activities of glycolytic and gluconeogenic enzymes. INTRODUCTION:The worldwide prevalence of diabetes mellitus (DM) has risen dramatically over the past two decades; based on current trends, more than 360 million individuals will be having diabetes by year 2030. Diabetes mellitus (DM) is the name given to a group of disorders characterized by chronic hyperglycaemia, polyurea, polydipsia, polyphagia, emaciation and weakness due to disturbance in carbohydrate, fat and protein metabolism associated with absolute or relative deficiency in insulin secretion and / or insulin action.

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Hypoglycaemic and antihyperglycaemic activity of <i>Ageratum conyzoides</i> l. In rats.

Cited by 23 publications

References 17 publications

Antihyperglycemic and antinociceptive activity evaluation of ‘Khoyer’ prepared from boiling the wood of <i>Acacia catechu</i> in water

Antihyperglycemic and antinociceptive activity evaluation of ‘Khoyer’ prepared from boiling the wood of <i>Acacia catechu</i> in water

Antioxidant Activity and Anti-Hyperglycemic Effect of Lagenaria Siceraria Fruit Extract

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