Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats

Prince, P. Stanely Mainzen; Menon, Venugopal P.

doi:10.1002/ptr.1130

Cited by 69 publications

(24 citation statements)

References 12 publications

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“…According to the Ayurvedic System of Medicine, T. cordifolia is an antigout, analgesic, rejuvenator, astringent, anthelmintic, antiarthritic, antiperiodic, antipyretic, antimalarial, antiinflammatory, aphrodisiac, antiasthmatic, bitter tonic, carminative, cardiotonic, constipative, digestant, diuretic, blood purifier, expectorant, antidiabetic, antigonorrhoeal, cholagogue, antiemetic and antiicteric5–7. T. cordifolia has been claimed to possess learning and memory enhancing8, antioxidant9, antiischemic10, hypolipidaemic11, antidiabetic12, antiulcer13, hepatoprotective14, antifertility15, antiinflammatory16, antiallergic17, immunomodulatory18, anticancer19 and radioprotective20. The chemical constituents of T. cordifolia stems include alkaloids like berberine, palmatine, tembetarine, magnoflorine2122, glycosides like tinocordiside23, tinocordifolioside, cordioside24, cordifolioside A, B25, cordifoliside A, B, C, D, E2627, steroids like ecdysterone, makisterone A, giloinsterol28, sesquiterpenoids like tinocordifolin29.…”

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confidence: 99%

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity ofTinospora cordifoliain mice

Dhingra¹,

Goyal²

2008

Indian J Pharm Sci

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The present study was taken up to investigate the effect of petroleum ether extract of Tinospora cordifolia (Wild.) Miers, on depression in mice. The extract (50, 100 and 200 mg/kg, p.o.) was administered for 14 successive days to Swiss young albino mice (either sex) and evaluated for antidepressant-like activity using tail suspension test and forced swim test. Petroleum ether extract at all three doses produced significant antidepressant-like effect in tail suspension test as well as in forced swim test and their efficacies were found to be comparable to imipramine (15 mg/kg, p.o.) and sertraline (20 mg/kg, p.o.). The extract at a dose of 50 mg/kg showed most potent effect and did not show any significant change in locomotor functions of mice as compared to control. The antidepressant-like effect of the extract was significantly reversed by pretreatment of animals with prazosin (a α1-adrenoceptor antagonist), sulpiride (a selective dopamine D2-receptor antagonist), p-CPA (a serotonin synthesis inhibitor) and baclofen (GABA-B agonist), when tested in tail suspension test. Moreover, petroleum ether extract also reduced the mouse whole brain monoamine oxidase (MAO-A and MAO-B) activities as compared to control, resulting in increase in the levels of brain monoamines. Therefore, the extract may have potential therapeutic value for the management of depressive disorders.

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confidence: 99%

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity ofTinospora cordifoliain mice

Dhingra¹,

Goyal²

2008

Indian J Pharm Sci

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“…The antioxidant activity of the extract may also be due to the presence of these alkaloids. In our earlier study we have shown that aqueous TCREt exhibits antioxidant activity (Stanely Mainzen Prince and Menon, 2003). In this communication, the alcoholic extract of TCREt was observed to have antioxidant effects, but the alcoholic extract showed a better effect than the aqueous extract and normalized all the parameters in alloxanized diabetic rats.…”

Section: Resultsmentioning

confidence: 89%

Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan‐induced diabetic liver and kidney

Prince

Padmanabhan

Menon

2004

Phytotherapy Research

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The present study investigates the effect of oral administration of an alcoholic extract of Tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats. A significant increase in the concentration of thiobarbituric acid reactive substances (TBARS) in liver and kidney was observed in diabetic rats. Decreased concentration of glutathione (GSH) and decreased activities of superoxide dismutase (SOD), and catalase in liver and kidney of diabetic rats were also noted. Alcoholic Tinospora cordifolia root extract (TCREt) administered at a dose of 100 mg/kg body weight to diabetic rats orally for six weeks normalized the antioxidant status of liver and kidney. The effect of Tinospora cordifolia root extract was more potent than glibenclamide (600 microg/kg body weight). Insulin (6 units/kg) restored all the parameters to normal status.

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“…Hence, we measured the lipid profile in the serum (total, LDL, non-HDL, and HDL cholesterol and triglycerides) and free fatty acid along with the LDL to HDL ratio and our results suggest prominent hypolipidemic effect for G-400. This effect was the consequence of the synergic effect of G-400 constituents as evident from early study of S. oblonga (Bhat et al, 2012), G. sylvestre (Daisy et al, 2009), T. cordifolia (Stanely Mainzen Prince andMenon, 2003), E. officinalis (Augusti et al, 2001) and C. longa (Babu and Srinivasan, 1997).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

Kurian

2016

Bangladesh J Pharmacol

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The present study evaluates the combinatorial effect of a poly-herbal combination with multiple therapeutic effects as a hypoglycemic and hypolipidemic agent. Herbal combination of Salacia oblonga, Tinospora cordifolia, Emblica officinalis, Curcuma longa and Gymnema sylvestre was prepared and administered to streptozotocin (55 mg/kg, i.p.)-induced diabetic rats, at a dose of 100 mg/kg, for four weeks. The poly-herbal combination significantly elevated the plasma insulin (90%) and reduced serum glucose (42%), cholesterol (49%), triglycerides (43%), LDL cholesterol (62.5%) and plasma apo B/apo A in the diabetic rats. The liver lipogenic enzymes like HMG CoA reductase and glucose-6-phosphatase significantly declined (p<0.05) in their activity while glucose-6-phosphate dehydrogenase and malic enzymes showed higher activity compared to the diabetic control. The results suggest a significant hypoglycemic and hypolipidemic property for the poly-herbal combination.

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Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats

Cited by 69 publications

References 12 publications

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity ofTinospora cordifoliain mice

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity ofTinospora cordifoliain mice

Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan‐induced diabetic liver and kidney

Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

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