Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals

Al-Shamaony, Loai A.; Al-Khazraji, Shahba M.; Twaij, Husni A.A.

doi:10.1016/0378-8741(94)90038-8

Cited by 327 publications

(183 citation statements)

References 9 publications

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“…The lowering effect of blood sugar levels by Ocimum lamiifolium in the same manner regardless of the dosage might suggest that the extract may have been absorbed in the cell system through active transport where a particular concentration saturation of the extract occurred resulting to the rest of extract being excreted [16]. Similar results have been reported on the hypoglycemic activity of plant extracts of L. wightiana and L. camara Linn [17,18], Artemisia herba [19] Colocynthis citrullus [20] and Ocimum gratissimum [21,22].…”

Section: Discussionsupporting

confidence: 75%

Hypoglycemic Effect of Ocimum Lamiifolium in Alloxan Induced Diabetic Mice

Wm¹,

Ho²

2016

Med Aromat Plants

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Section: Discussionsupporting

confidence: 75%

Hypoglycemic Effect of Ocimum Lamiifolium in Alloxan Induced Diabetic Mice

Wm¹,

Ho²

2016

Med Aromat Plants

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“…In this study, we have noticed elevated levels of serum lipids such as cholesterol and triglycerides in diabetic rats. The levels of increased serum lipids in diabetes represent a risk factor for coronary heart disease (Al-Shamaony et al, 1994). Under normal circumstances, insulin activates lipoprotein lipase and hydrolyzes lipoprotein bound triglycerides (Ng et al, 1987;Welihinda et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effect ofStreblus asperin streptozotocin-induced diabetic rats

Karan

Mondal

Mishra

et al. 2013

Pharmaceutical Biology

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“…Insulin is a potent inhibitor of lipolysis by inhibiting the activity of the lipases and holds back the release of FFAs from the adipose tissue (Al-Shamaony et al 1994). An elevated activity of this enzyme observed under diabetic condition that enhances the lipolysis and releases FFAs into the circulation which in turn increases the b-oxidation of fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats

Ayyasamy

Pari

2016

Pharmaceutical Biology

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Context: Myrtenal is monoterpene a constituent of essential oils found mainly in herbs such as mint, pepper, cumin, etc. It exerts admirable pharmacological activities against many diseases including diabetes. Hyperlipidaemia is a secondary complication of diabetes and also a major risk factor for cardiovascular diseases.Objective: The present study investigated the possible antihyperlipidaemic efficacy of myrtenal on plasma glucose, pancreatic insulin, plasma and tissue lipid levels in streptozotocin (STZ) induced diabetic rats. Materials and methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg b.w.). Myrtenal (80 mg/kg) was administered orally to diabetic rats for a period of 28 d. Plasma glucose, pancreatic insulin, TC, TGs, FFAs, PLs, LDL-C, HDL-C, VLDL, atherogenic index, (HMG-CoA) reductase, LPL, LCAT and liver histology were analyzed. Results: Diabetic rats showed significantly (p < 0.05) increased plasma glucose (273.18 mg/dL), total cholesterol (142 mg/dL), triglycerides (126 mg/dL), free fatty acids (118 mg/dL), phospholipids (153 mg/dL), lowdensity lipoprotein (88.07 mg/dL), very low-density lipoprotein (25.2 mg/dL), atherogenic index, whereas a decrease in the levels of pancreatic insulin (97.48 ng/mg) and high-density lipoprotein (29.12 mg/dL). In addition, the activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase (0.94 HMG-CoA ratio/(mevalonate) increased significantly in contrast to the activities of lipoprotein lipase (4.87 lmoles of glycerol liberated/h/L) and lecithin cholesterol acyltransferase (54.61 lmoles of cholesterol esterified/h/L) in diabetic rats. Treatment with myrtenal significantly (p < 0.05) improved the levels of plasma glucose, pancreatic insulin and lipid profiles. Moreover, the histopathological analysis of liver was also in agreement with the biochemical findings. Discussion and conclusions: The present study indicates that myrtenal possess antihyperglycaemic and antihyperlipidemic properties, and could potentially be a useful phytochemical in treating diabetes. ARTICLE HISTORY

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Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals

Cited by 327 publications

References 9 publications

Hypoglycemic Effect of Ocimum Lamiifolium in Alloxan Induced Diabetic Mice

Hypoglycemic Effect of Ocimum Lamiifolium in Alloxan Induced Diabetic Mice

Antidiabetic effect ofStreblus asperin streptozotocin-induced diabetic rats

Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats

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