Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats

Meliani, Nawel; Dib, Mohammed El Amine; Allali, Hocine; Tabti, Boufeldja

doi:10.1016/s2221-1691(11)60102-0

Cited by 99 publications

(53 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DM is a major illness characterized by hyperglycemia due to absolute or relative deficiency of insulin [1]. In this study, we have demonstrated that an alcoholic extract of the B.vulgaris plant is able to normalize blood glucose levels and reduce stress protein expression in rats with streptozotocin-induced diabetes.…”

Section: Discussionmentioning

confidence: 71%

“…Of these, hyperglycemia is a major cause of absolute or relative insulin deficiency. According to World Health Organization projections, the diabetic population may increase to ≥300 million by 2050 [1]. Free radical production is stimulated by hyperglycemia, leading to cell damage.…”

Section: Introductionmentioning

confidence: 99%

“…The root bark of B.vulgaris is recommended in the management of diabetes. However, the mechanisms action of the plant remains unknown, and in addition, the use of antioxidants for disease therapy remains debatable [1]. Some natural compounds such as antioxidants are effective in protecting the human body against damage caused by ROS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

et al. 2016

View full text Add to dashboard Cite

Background: Finding a treatment for diabetes that does not have side effects has remained elusive. Among natural agents, much attention has been focused on phenolic compounds. For both their medicinal and nutritional value, barberry plants are of particular interest. Berberis vulgaris is known for its medicinal benefits in Iranian traditional medicine. In this study, we investigated the biological activities of B.vulgaris in a rodent model of experimentally induced diabetes. Method: The fasting blood glucose (FBG), insulin, malondialdehyde (MDA), and total antioxidant levels were measured in experimental groups of rats, including normoglycemic control, diabetic control, and diabetics treated with B.vulgaris, and the gene expression of the stress proteins HSF-1, HSP27, and HSP70 as well as the enzymes glucokinase (GK) and glucose 6-phosphatase (G6P) were assayed by real-time PCR.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…25 On the other hand, administration of ethanolic leaf extract of (CSCoriandrum sativum) on alloxan induced diabetic rats for 4 weeks, the increased level of blood glucose was decreased due to the active principles present in these extracts such as Flavonoids, tannin, alkaloids saponin. 26 which possess the properties enhance insulin secretion, alteration of β-cell, improvement of hepatic glutathione concentration, pancreatic lipase. Earlier reported by.…”

Section: Discussionmentioning

confidence: 99%

To Evaluate the Antidiabetic and Rejuvenating Capability of Tissues on Alloxan Induced Diabetic Rats under the Effect of Ethanolic Leaf Extract of Coriandrum sativum: A Histopathological Study

Sharma¹,

Sharma²,

Joshi³

et al. 2017

View full text Add to dashboard Cite

Objective:To evaluate the antidiabetic and rejuvenating capability of tissues on alloxan induced diabetic rats under the effect of ethanolic leaf extract of Coriandrum sativum. Methods: Diabetic model was prepared by administration of alloxan monohydrate (150 mg/ kg i.p). The ethanolic leaf extracts of Coriandrum sativum at a dose of 200 and 400 mg/kg of body weight were administrated to diabetic induced groups for a period of 28 days. The effect of ethanolic leaf extract of Coriandrum sativum leaf extract on serum blood glucose, insulin, lipase, α-amylase and LDH as well as kidney function test [urea, uric acid, albumin, protein and creatinine] were measured in the alloxan induced diabetic rats. Results: In the acute toxicity study, ethanolic leaf extract of Coriandrum sativum leaf was non-toxic at 2 000 mg/kg in rats. The increased insulin level, albumin and protein level, decreased blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Coriandrum sativum leaf compared to diabetic control rats. In Histopathological study were revealed toward normal. Conclusion: Ethanolic extract of Coriandrum sativum leaf possesses significant antidiabetic and rejuvenating capability of tissues.

show abstract

“…Barberries have reported as hepatoprotective, hypoglycemic and as a herbal remedy for the treatment of a variety of complaints including diabetes, liver dysfunction (Jaundice), gallbadder pain, gall stone diarrhea, indigestion and urinary tract diseases (Hermenean et al, 2012;Meliani et al, 2011;Jellin et al, 2000;Chevallier, 1996;Gruenwald, 1998). Earlier the aqueous and methanolic extract from Berberis vulgaris fruit and root was tested to evaluate its antihypertensive effects on DOCA-induced hypertension in the rats (Fatehi et al, 2005b;Azmat et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Hypotensive activity, toxicology and histopathology of different extracts of Berberis vulgaris

Azmat¹,

Ahmed²

2014

J. Med. Plants Res.

View full text Add to dashboard Cite

A number of plants have been used widely in the traditional system of medicine or Tibb-e-Unani (Unani medicine) in the management of many diseases but these mostly, have not been investigated for their described effects. In this study, the hypotensive, toxicology and histological activities were studied in normotensive albino rats at different doses of ethanolic extract of root pulp (BRE) and aqueous extract of root pulp (BRD). The receptor activity was assessed by using the drugs acetylcholine (Ach) and atropine (Atr) on rat heart. Administration of different extracts (BRE and BRD) showed significant reduction in blood pressure comparable to its respective control. While on pre-treatment with Atr (10 -4 M) the BRE (10 mg/kg) and BRD (20 mg/kg) did not produce any reduction in blood pressure. These behavior matches exactly to that of acetylcholine (1 µg/kg). The results confirmed that oral and intraperitoneal administration of BRE does not indicate any structural and functional disturbance of liver, heart and kidney up to the dose 100 mg/kg. While, 1000 mg/kg appeared as lethal dose (LD) and all mice died at the interval of 24 h. In conclusion, different extract of BRE used in this study caused hypotensive effect by stimulating non-selective muscarinic receptors. The toxicological, hematological and histopathological results further confirm the safety of BRE up to the dose of 100 mg/kg.

show abstract

Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats

Abstract: These results demonstrated significant antidiabetic effects and showed that serum cholesterol and serum triglycerides levels were decreased, significantly, consequently this plant might be of value in diabetes treatment.

Cited by 99 publications

References 26 publications

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

Effects of an ethanolic extract of Berberis vulgaris fruits on hyperglycemia and related gene expression in streptozotocin-induced diabetic rats

To Evaluate the Antidiabetic and Rejuvenating Capability of Tissues on Alloxan Induced Diabetic Rats under the Effect of Ethanolic Leaf Extract of Coriandrum sativum: A Histopathological Study

Hypotensive activity, toxicology and histopathology of different extracts of Berberis vulgaris

Contact Info

Product

Resources

About