Hypoglycaemic Effects of Viscous Preparation of<i>Irvingia gabonensis</i>(Dikanut) Seeds in Streptozotocin-Induced Diabetic Wistar Rats

Ozolua, Raymond I.; Eriyamremu, George E.; Okene, Eseoghene O.; Ochei, Uche

doi:10.1300/j044v12n04_01

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…Our results are in accordance with the findings of other investigators where it has been claimed that three weeks consumption of a viscous preparation of I. gabonensis resulted in a decreased blood glucose (P<0.05), pyruvate kinase and lactate dehydrogenase activities (P<0.05); and also increased glucose-6-phosphatase activity (P<0.05) in dikanut-fed diabetic rats compared with others not fed dikanuts. 18 It is well established that dyslipidemia, especially hypertriglyceridemia is a common finding in patients with diabetes mellitus and is responsible for vascular complications. 19 It has also been claimed that deficiency of lipoprotein lipase activity may contribute significantly to the elevation of triglyceroides in diabetes.…”

Section: Resultsmentioning

confidence: 99%

“…It is known that I. gabonensis seeds may contain soluble dietary fibers that are bulk-forming laxatives. It is well established that dietary fibers delay stomach emptying; leading to a more gradual absorption of dietary 18 sugar which is probably responsible for glucose lowering effect seen in Type 2 diabetic model rats with the treatment of I. gabonensis seeds (both powder and extract).…”

Section: Resultsmentioning

confidence: 99%

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Hypoglycemic effect of Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill in Type 2 Diabetic Long-Evans Rats

Hossain

Sokeng

Shoeb

et al. 2012

Dhaka Univ. J. Pharm. Sci

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ABSTRACT:Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill (African wild mango/bush mango) seeds are widely used in cooking as a sauce in Cameroon and in most parts of tropical Africa for the treatment of a number of ailments. In this study normal rat food was incorporated with I. gabonensis seed powder (10%) and oil free seed powder (5%) and their chronic effects on streptozotocin induced Type 2 diabetic rats were studied. Oral consumption of food incorporated with seed powder significantly reduced serum glucose level on the 28th day (p<0.01) which was comparable with glibenclamide treated group. Food with oil free seed powder showed 24% fall in glucose level on the 28 th day. Fasting serum insulin increased significantly (p<0.001) in glibenclamide and oil free seed powder treated (p<0.008) groups. No effect was observed in the seed powder treated group. Liver glycogen content increased in the glibenclamide treated group but no significant change was observed in both powder and oil free seed powder treated groups. On the 28 th day seed powder treated group significantly lowered serum TG level (p<0.033) and 48%was lowered by oil free seed powder. It is concluded that seed powder as well as oil free seed powder lowered blood glucose level in Type 2 diabetic model rats. It seems to act as an insulinomimetic and/or insulin sensitizing agent.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hypoglycemic effect of Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill in Type 2 Diabetic Long-Evans Rats

Hossain

Sokeng

Shoeb

et al. 2012

Dhaka Univ. J. Pharm. Sci

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“…Oral administration of the ethanolic extract of rhizomes of N. nucifera significantly reduced the blood sugar level of normal, glucose hyperglycemic, and streptozotocin-induced diabetic rats when compared with control animals. The extract increased glucose tolerance and potentiated the action of exogenously injected insulin in normal rats [33,34].…”

Section: N Nuciferamentioning

confidence: 88%

Medicinal Plants for Diabetes Mellitus: A Review

Shelke¹,

Sm²

2021

Asian J Pharm Clin Res

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Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Fourth leading causes of death in the most advanced countries and there, in other emerging and recently industrialized nations, still controlled the epidemic. Inadequate control of blood sugar has significant consequences for well-being. Ayurveda and other Indian writing referenced the utilized of plants in the treatment of different diseases. Medicinal plant with antidiabetic potential has been recent area of research. The efficiency of these medicinal plants may regulate the diabetic metabolic abnormalities. This work would help researchers to choose potential herbal for diabetic treatment.

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“…The fruit is spherical with smooth yellow fibrous mesocarp and hard endocarp when ripe. The seed from the plant has been of interest in the food [136,[141][142][143], beverages [144][145][146], medical [135,[147][148][149][150][151][152] and pharmaceutical [153][154][155][156][157][158][159][160][161][162] as well as cosmetic circles [163]. The seed of the plant contains lipids and polymeric constituents [105,137,146,[164][165][166][167].…”

Section: Guar Gummentioning

confidence: 99%

Advances in Natural Polymers as Pharmaceutical Excipients

Ogaji¹,

Nep²,

Audu-Peter³

2012

Pharm Anal Acta

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Research in natural polymeric materials has witnessed growing interest and attention. This is attributable to a number of factors which include their relative abundance, low cost, and biodegrable and eco-firendly profiles. This article reviews the current applications of natural polymeric materials in pharmaceutical formulations. The pharmaceutical applications of some of the traditional and commercially available natural polymers were discussed. Emerging potential pharmaceutical excipients of natural origins were also discussed. The increasing research interests in this group of materials are indications of their increasing importance. It is believed that as technology and testing techniques advance, more understanding of their physicochemical nature would be gained that can enable them to be tailored for wider Pharmaceutical applications than their synthetic counterparts.

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Hypoglycaemic Effects of Viscous Preparation ofIrvingia gabonensis(Dikanut) Seeds in Streptozotocin-Induced Diabetic Wistar Rats

Cited by 12 publications

References 22 publications

Hypoglycemic effect of Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill in Type 2 Diabetic Long-Evans Rats

Hypoglycemic effect of Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill in Type 2 Diabetic Long-Evans Rats

Medicinal Plants for Diabetes Mellitus: A Review

Advances in Natural Polymers as Pharmaceutical Excipients

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