Hypoglycemia in type 2 diabetes patients treated with insulin: the advantages of continuous glucose monitoring

Abstract

Aims. To determine the incidence and risk factors for hypoglycemia in elderly insulin-treated type 2 diabetes mellitus (T2DM) patients by means of continuous glucose monitoring (CGM). Materials and Methods. We observed seventy-six hospitalized patients with T2DM, aged 65 to 79 years. Treatment with basal insulin (n=36), premixed insulin (n=12) or basal-bolus insulin regimen (n=28) was followed by metformin (n=44), glimepiride (n=14) and dipeptidyl peptidase-4 inhibitors (n=14). 2-days CGM with retrospective data analysis was performed in all patients. During CGM, three fasting and three 2-h postprandial finger-prick glucose values were obtained daily with portable glucose meter. Results. Hypoglycemia (identified as blood glucose

Safety of basal-bolus versus premixed insulin intensification regimens in the management of type 2 diabetes mellitus: A narrative review of a 14-year experience

“…Our initial search identified 20 papers, 12,21e39 five studies of which were excludes 21,24,32,38,39 because they compared regimens other than the two specific regimens, two were excluded because they involved Type 1 Diabetes Mellitus patients, 22,34 two were excluded because there was no safety related parameter measured in the study 31,35 and one was excluded due to different injection formulations used for the BB regimen arm. 37 The remaining ten selected studies and their characteristics were analysed as shown in Table 1.…”

The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy

“…В данном исследовании мы подтвердили данные о достаточно высокой распространенности эпизодов низкого уровня глюкозы, выявляемых с помощью НМГ, у больных СД2, получающих инсулин [21]. Несмотря на сходную суточную дозу инсулина и отсутствие мет-формина, средний уровень глюкозы по данным НМГ у пациенток с СКФ в диапазоне 30-44 мл/мин/1,73 м 2 оказался несколько ниже, чем у больных других групп.…”

Impaired hypoglycemia awareness in diabetes: epidemiology, mechanisms and therapeutic approaches

“…Большое значение имеют результаты самоконтроля гликемии, занесенные в память глюкометра или в дневник пациента. Для выявления скрытых эпизодов гипогликемии целесообразно провести НМГ [60]. Далее осуществляется индивидуализация целевых значений гликемии (обычно устанавливаются на более высоких цифрах, чем у больных без НРГ).…”