Hypoglycemic Activity Of &lt;i&gt;Polygala arvensis&lt;/i&gt; In Normal And Alloxan Induced Diabetic Rats

Sammaiah, G.; Thirupathi, K.; Narsaiah, N.; Srivastava, R.C.

doi:10.4314/njnpm.v11i1.11877

Cited by 3 publications

(4 citation statements)

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“…Northern border region of Saudi Arabia [18] In intravenous administration of alloxan-induced diabetic rabbits glucose level lowering effect observed (time dependent manner) with P. ovata husk extract of dose level (300 mg/kg, orally administered) [109] Polygala erioptera Polygalaceae Aerial part Jazan Region [84] 0.7 g/kg of P. erioptera extract showed significant antidiabetic effect compared to standard drug metformin and glibenclamide in normal and alloxan-induced diabetic rats [110] Polygonum aviculare L Polygonaceae Aerial parts Taif Region [111,112] Many ethnopharmacological investigations reported its antidiabetic potential but still need to study its in vivo and in vitro antidiabetic potential [113,114] Ziziphus spinachristi Rhamnaceae Leaves Eastern region of Saudi Arabia [84,112] e strongest (P < 0.001) antidiabetic activity (25.59 and 39.48% after 7 and 15 days, respectively) was found following treatment with dose level of 500 mg/kg of Z. spina-christi extract in streptozotocin-induced diabetes mice [115].…”

Section: Plantago Ovatamentioning

confidence: 99%

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Alqahtani

Ullah

Shahat

2022

Evidence-Based Complementary and Alternative Medicine

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The purpose of this review is to summarize the available antidiabetic medicinal plants in the Kingdom of Saudi Arabia with its phytoconstituents and toxicological findings supporting by the latest literature. Required data about medicinal plants having antidiabetic activities and growing in the Kingdom of Saudi Arabia were searched/collected from the online databases including Wiley, Google, PubMed, Google Scholar, ScienceDirect, and Scopus. Keywords used in search are in vivo antidiabetic activities, flora of Saudi Arabia, active ingredients, toxicological evaluations, and medicinal plants. A total of 50 plant species belonging to 27 families were found in the flora of Saudi Arabia. Dominant family was found Lamiaceae with 5 species (highest) followed by Moraceae with 4 species. β-Amyrin, β-sitosterol, stigmasterol, oleanolic acid, ursolic acid, rutin, chlorogenic acid, quercetin, and kaempferol are the very common bioactive constituents of these selected plant species. This paper has presented a list of antidiabetic plants used in the treatment of diabetes mellitus. Bioactive antidiabetic phytoconstituents which showed that these plants have hypoglycemic effects and highly recommended for further pharmacological purposes and to isolate/identify antidiabetes mellitus (anti-DM) active agents also need to investigate the side effects of active ingredients.

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Section: Plantago Ovatamentioning

confidence: 99%

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Alqahtani

Ullah

Shahat

2022

Evidence-Based Complementary and Alternative Medicine

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“…[2,3] Presently insulin and synthetic oral hypoglycaemic agents are the major players in management of it. [1] Frequently herbal medication is also preferred as one of the alternative methods. There are many antidiabetic herbs recommended in traditional medicaments, but still there is a worldwide quest for an ideal drug due to complex nature of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…[1] DM is mainly characterized by abnormally elevated blood glucose level. It also shows altered metabolism of carbohydrates, lipids, and proteins with an increased risk of vascular and renal diseases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hypoglycaemic activity of Cassia nodosa leaves in normal and streptozotocin-induced diabetic rats

Kumavat¹,

Jagdale²,

Shimpi³

2012

Int J Green Pharm

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In present work, one novel ornamental plant Cassia nodosa Buch.-Ham. ex Roxb. has been investigated for hypoglycaemic action. It aimed to check the hypoglycaemic effect of C. nodosa leaves on normal and streptozotocin-induced diabetic rats by acute and sub-acute studies. Prior to the hypoglycaemic study, acute oral toxicity testing of drug was performed. Later the effects of single and multiple doses of test drug were studied using various parameters. Dried powdered leaf material was used as an oral drug. The preliminary phytochemistry of drug was done by standard qualitative tests. Diabetes was induced in rats by single intraperitoneal injection of streptozotocin. Single and multiple doses of test drug (0.5 g/kg body weight/day) were given to normal and diabetic rats. The parameters studied were blood glucose, serum cholesterol, serum triglycerides and serum proteins. The results of test drug were compared with standard hypoglycaemic drug-glibenclamide (0.01 g/ kg/day). It was done by 'Student's 't' test' and one-way ANOVA test. In preliminary phytochemistry antidiabetic compounds were detected. Unlike acute, sub-acute treatment of test drug showed highly significant reduction (40.29%) in blood glucose level of diabetic rats in 10 days. This effect was considerably good in comparison with standard drug (63.51%). The test drug and standard drug exhibited an insignificant change in the abnormal levels of serum metabolites of diabetic rats. Preclinically C. nodosa was proved to be an effective hypoglycaemic agent.

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“…[ 1 2 ] Despite harmful side effects, insulin and synthetic oral hypoglycemic agents are widely used in management of Diabetes mellitus. [ 3 ] Frequently, herbal remedies are also preferred as they are safe for long-term use, easily accessible, and cost effective. There are many antidiabetic herbs recommended in traditional medicaments but still there is a worldwide quest for an ideal drug due to complex nature of the disease.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic activity of Cassia javanica Linn. in normal and streptozotocin-induced diabetic rats

Kumavat¹,

Shimpi²,

Jagdale³

2012

J Adv Pharm Technol Res

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Hypoglycemic Activity Of <i>Polygala arvensis</i> In Normal And Alloxan Induced Diabetic Rats

Cited by 3 publications

References 0 publications

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Evaluation of hypoglycaemic activity of Cassia nodosa leaves in normal and streptozotocin-induced diabetic rats

Hypoglycemic activity of Cassia javanica Linn. in normal and streptozotocin-induced diabetic rats

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