Hypoglycemic Activity of Polysaccharide Fraction from Rhizome of Rehmannia glutinosa LIBOSCH. f. hueichingensis HSIAO and the Effect on Carbohydrate Metabolism in Normal Mouse Liver

Kiho, Tadashi; Watanabe, Toshiaki; Nagai, Katsuyuki; Ukai, Shigeo

doi:10.1248/yakushi1947.112.6_393

Cited by 23 publications

(19 citation statements)

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“…Indeed, studies have shown that SJH has hypoglycemic effects [21,48]. The water extract of Rehmannia glutinosa Libosch.…”

Section: Discussionmentioning

confidence: 99%

“…(Saengjihwang in Korean; SJH) has been traditionally prescribed in Korean medicine to reduce fever and regulate immunity. Recently, SJH is used for the treatment of various diabetic disorders [19] as pharmacological studies show thrombolytic [20] and hypoglycemic activities [21] and improvement of renal functions in diabetic nephropathy [22,23]. SJH also suppresses the production of TNF-α and IL-1 in mouse astrocytes [24].…”

Section: Introductionmentioning

confidence: 99%

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Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

Baek

Jang

Jeong³

et al. 2012

Inflammation

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Fresh rhizome of Rehmannia glutinosa Libosch. (Saeng-jihwang in Korean: SJH) has been prescribed for the treatment of diabetes-associated complications. The purpose of the present study is to investigate the underlying mechanisms of the efficacy of SJH in diabetes-related complications. Decoction was obtained after boiling SJH in water and subsequent lyophilization. The cellular toxicity of SJH was determined by MTT assay. The antioxidant activity of SJH was measured by DPPH and DCFH-DA assays. The effects of SJH on inflammatory responses elicited by AGEs were assessed by western blotting and semi-quantitative RT-PCR analyses. The water extract of SJH had a high free radical scavenging activity in vitro and decreased the level of intracellular ROS in THP-1 cells treated with AGEs. SJH suppressed the expression of pro-inflammatory genes, including TNF-α, MCP-1, IP-10, COX-2, and iNOS; the activation of NF-κB; and the expression of RAGE, a receptor for AGEs, where the expressions of which were induced by AGEs. These results suggest the possibility that SJH can be an alternative therapeutics for diabetes-associated diseases.

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“…Indeed, studies have shown that SJH has hypoglycemic effects [21,48]. The water extract of Rehmannia glutinosa Libosch.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

Baek

Jang

Jeong³

et al. 2012

Inflammation

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“…Rehmanniae Radix (RehR), a root of Rehmannia glutinosa Liboschitz var. purpurea Makino or Rehmannia glutinosa Liboschitz (Scrophulariaceae), is known to have hypoglycemic activity against mammals, and is widely prescribed for patients with diabetes (19,20). We asked whether the hypoglycemic effect of the RehR could be observed in the hyperglycemic silkworms.…”

Section: Evaluation Of the Hypoglycemic Activities In Extracts Of Rehmentioning

confidence: 99%

A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine

Matsumoto

Sekimizu

2016

DD&T

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“…The water extract was concentrated in vacuo, and then treated with ethanol in the proportion of 1:3, being stirred and stood for 12 h at −4°C. The crude polysaccharides were filtered and lyophilized into powder (yield of 8%) (Chanarat et al, 1997;Kiho et al, 1992).…”

Section: Preparation Of Polysaccharidesmentioning

confidence: 99%

Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia‐houpu decoction

Guo

Kong

Wang

et al. 2004

Phytotherapy Research

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Banxia-houpu decoction, a traditional Chinese medicine has been used in the treatment of depression. The present study confirmed that oral administration of polysaccharides from Banxia-houpu decoction, exhibited a reduction in the immobility time in the tail suspension and in the forced swimming tests in mice in a time-dependent manner. This effect at a dose of 320 mg/kg was more potent than that at a dose of 640 mg/kg. The polysaccharides from Banxia-houpu decoction were active in animal models of depression with comparable effects to known antidepressants. The oral administration of the polysaccharides at a low dose for 4 weeks resulted in a significant increase in the monoamine neurotransmitter 5-hydroxytryptamine (5-HT) and dopamine (DA) levels in whole mouse brain, but produced no significant increase in 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) concentrations. The effect of polysaccharides on the brain neurotransmitter levels appeared to be quite different from the effect of fluoxetine, a serotonin specific reuptake inhibitor. The results indicate that the mode of action of polysaccharides from Banxia-houpu decoction in depression might be related to both 5-HT and DA systems.

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Hypoglycemic Activity of Polysaccharide Fraction from Rhizome of Rehmannia glutinosa LIBOSCH. f. hueichingensis HSIAO and the Effect on Carbohydrate Metabolism in Normal Mouse Liver

Cited by 23 publications

References 0 publications

Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products

A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine

Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia‐houpu decoction

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