Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from Aeculus hippocastanum Seeds

Sharipov, Avez; Tursunov, Khurshid; Fazliev, Sunnatullo; Azimova, Bahtigul; Razzokov, Jamoliddin

doi:10.3390/molecules26133784

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…Flowers of red horse chestnuts contain a satisfactory level of anthocyanin compounds compared with berry fruits such as highbush blueberry, strawberry, and raspberry [ 35 ]. In addition to diminishing disease risk, other functions of plant flavonoids connected with horse chestnut flowers, fruits, leaves, and seeds include vessel strength and wound healing [ 36 ]. Therefore, it may be worth combining the health-promoting and therapeutic effects of horse chestnut flowers and leaves due to their high content of polyphenolic compounds, particularly flavonoids.…”

Section: Discussionmentioning

confidence: 99%

Red Horse Chestnut and Horse Chestnut Flowers and Leaves: A Potential and Powerful Source of Polyphenols with High Antioxidant Capacity

et al. 2022

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Aesculus flowers and leaves are an excellent source of bioactive compounds, including flavanols, phenolic acids, and anthocyanins, and the leaves also contain antioxidant carotenoids and chlorophylls. The aim of this study was to analyse and compare the amounts of bioactive compounds present in Aesculus hippocastanum and Aesculus × carnea flowers and leaves over two years. These two species from six independent locations (parks and green areas) located in Warsaw were assessed in this study. The dry matter by the scale method and polyphenol, carotenoid, and chlorophyll content by the HPLC method of the flowers and leaves was evaluated. Red horse chestnut flowers contained significantly more total carotenoids (40.6 µg/g FW) and chlorophylls (36.9 µg/g FW) than horse chestnut flowers, and red horse chestnut flowers contained higher levels of anthocyanins (5.41 µg/g FW) than other species. We observed that horse chestnut flowers were characterized by a higher total polyphenols concentration (9.45 µg/g FW) compared to red horse chestnut flowers. In addition, the analysis of leaves showed that all quality parameters were higher in red horse chestnut species. Five individual anthocyanins were identified in both species’ flowers, but a higher concentration was found in red horse chestnut flowers, and pelargonidin-3-O-glucoside was the predominant form among a pool of total anthocyanins. In both experimental years, leaves (109.25 mMol/100 g FW and 112.0 mMol/100 g FW) were characterized by a higher antioxidant activity than flowers (27.0 mMol/100 g FW and 27.5 mMol/100 g FW).

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Section: Discussionmentioning

confidence: 99%

Red Horse Chestnut and Horse Chestnut Flowers and Leaves: A Potential and Powerful Source of Polyphenols with High Antioxidant Capacity

et al. 2022

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“…Many biological activities of aescin validate the traditional use of seed extracts. Aescin exhibits potent anti-inflammatory [31,32,48,49], anticancer [44,[50][51][52], antiviral [46,[53][54][55], antifungal [35], antidiabetic [34,45,48], antiedema [32], antioxidative [49,56,57] and anti-apoptotic [39] effects. Aescin is a promising phytochemical for anticancer drug development [50], as well as for the treatment of neurodegenerative diseases [39], neuropathy [58] and diabetic nephropathy [59].…”

Section: Medicinal Uses Of Aesculus Spmentioning

confidence: 99%

Tissue Culture Response of Ornamental and Medicinal Aesculus Species—A Review

Zdravković-Korać

Milojević

Belić

et al. 2022

Plants

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Species of the genus Aesculus are very attractive woody ornamentals. Their organs contain numerous health‑promoting phytochemicals. The most valuable of them—aescin—is used in commercial preparations for the treatment of venous insufficiency. The industrial source of aescin is horse chestnut seeds because the zygotic embryos are the main site of its accumulation. Horse chestnut somatic and zygotic embryos contain similar amount of aescin, hence somatic embryos could be exploited as an alternative source of aescin. Somatic embryogenesis, androgenesis and de novo shoot organogenesis were successfully achieved in several Aesculus species, as well as secondary somatic embryogenesis and shoot organogenesis, which enables mass production of embryos and shoots. In addition, an efficient method for cryopreservation of embryogenic tissue was established, assuring constant availability of the plant material. The developed methods are suitable for clonal propagation of elite specimens selected as the best aescin producers, the most attractive ornamentals or plants resistant to pests and diseases. These methods are also useful for molecular breeding purposes. Thus, in this review, the medicinal uses and a comprehensive survey of in vitro propagation methods established for Aesculus species, as well as the feasibility of in vitro production of aescin, are presented and discussed.

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“…Polysaccharides from Apostichopus japonicus also have antihyperlipidemic and antioxidant attributes ( 17 ). Triterpene glycosides (or triterpene saponin) exhibit hypolipidemic ( 18 ), anti-inflammatory ( 19 ), immunomodulatory ( 20 ), and wound-healing properties ( 21 ), which indirectly contribute to dyslipidemia. Triterpene glycosides are also known to interact with sterol in the membrane of sea cucumbers as a self-defense mechanism against saponin ( 22 , 23 ).…”

Section: Anticholesterol Property Of Sea Cucumbersmentioning

confidence: 99%

Anticancer and anticholesterol attributes of sea cucumbers: An opinion in terms of functional food applications

et al. 2022

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Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from Aeculus hippocastanum Seeds

Cited by 8 publications

References 41 publications

Red Horse Chestnut and Horse Chestnut Flowers and Leaves: A Potential and Powerful Source of Polyphenols with High Antioxidant Capacity

Red Horse Chestnut and Horse Chestnut Flowers and Leaves: A Potential and Powerful Source of Polyphenols with High Antioxidant Capacity

Tissue Culture Response of Ornamental and Medicinal Aesculus Species—A Review

Anticancer and anticholesterol attributes of sea cucumbers: An opinion in terms of functional food applications

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