Hypoglycemic and antihyperglycemic effects of newly synthesized sulfonyloxy derivatives of azalactone in normal and alloxan diabetic rabbits

Ak, Jain; Sc, Mehta; Shrivastava, NM

doi:10.4103/0253-7613.19078

Cited by 9 publications

(8 citation statements)

References 1 publication

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the monoclinic polymorph of the title compound, see: Ploug-Sørensen & Andersen (1986). For the applications of nitroanilines, see: Jain et al (2005); Teng & Garito (1983). For information on polymorphism, see: Davey (2003); Li et al (2001); Rodríguez-Spong et al (2004).…”

Section: Related Literaturementioning

confidence: 99%

“…4-Nitroaniline and 3-nitroaniline serve as the reference compounds in both, experimental and computational studies on optical nonlinearity (Teng & Garito, 1983). Also 3-Nitroaniline and its derivatives are biologically important compounds owing to the production of significant hypoglycemic as well as antihyperglycemic effects in normal and alloxan-induced diabetic rabbits (Jain et al, 2005). Organic molecules including most of pharmaceutical compounds are prone to polymorphic formation in the solid state.…”

Section: S1 Commentmentioning

confidence: 99%

See 1 more Smart Citation

A triclinic polymorph of 3-nitroanilinium chloride

Thangarasu

Athimoolam²,

Bahadur

2011

Acta Cryst E

View full text Add to dashboard Cite

The asymmetric unit of the title compound, C6H7N2O2 +·Cl−, contains two independent ion pairs. A monoclinic form of the title compound with only one ion pair in the asymmetric unit has been reported previously [Ploug-Sørensen & Andersen (1986). Acta Cryst. C42, 1813–1815]. In the crystal of the title compound, the components are linked into layers parallel to (001) by intermolecular N—H⋯Cl hydrogen bonds, with alternating hydrophilic and hydrophobic regions.

show abstract

Section: Related Literaturementioning

confidence: 99%

Section: S1 Commentmentioning

confidence: 99%

A triclinic polymorph of 3-nitroanilinium chloride

Thangarasu

Athimoolam²,

Bahadur

2011

Acta Cryst E

View full text Add to dashboard Cite

show abstract

“…The World Health Organization (WHO) had great restrictions on the use of ethnomedicines for control and treatment of DM [ 19 , 20 ]. Around 1200 or more plants have been exploited as traditional medicine [ 21 , 22 ], owing to their hypoglycemic effects with about 800 plants were scientifically reported as potential evidence-based medicine to manage DM [ 23 ]. Originally derived from Galega officinalis , metformin is a well-known hypoglycemic drug with a historical background, providing a vivid example of studying medicinal plants for the development of pharmaceuticals [ 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Safety of Stewart’s Wood Fern (Dryopteris stewartii) and Its Anti-Hyperglycemic Potential in Alloxan-Induced Diabetic Mice

Hanif

Raza

Liaqat

et al. 2022

IJMS

View full text Add to dashboard Cite

Diabetes has become a critical challenge to the global health concerns. Cytotoxicity and development of resistance against available drugs for management of diabetes have shifted the focus of global scientific researchers from synthetic to herbal medications. Therefore, the current study was conducted to investigate the possible anti-hyperglycemic potential of Dryopteris stewartii using Swiss albino mice. To evaluate any possible toxic effect of the plant, acute oral toxicity test was performed while the anti-diabetic effects of aqueous and ethanol extracts at 500 mg/kg, positive, negative and normal control were assessed simultaneously. The anti-diabetic study revealed that aqueous extract has higher anti-diabetic potential than ethanol extract while lowered blood glucose level at second week reaching 150 mg/dL, exerting stronger anti-diabetic effects, compared to ethanol extract (190 mg/dL). Oral glucose tolerance findings revealed that aqueous extract decreased blood glucose level by −0.41-fold, compared to ethanol extract showing a decrease by only −0.29-folds. The histopathological evaluation of liver and pancreas of all groups revealed normal cell architecture with no morphological abnormalities. These results suggested the possible use of D. stewartii as anti-diabetic herbal drug in near future. However, these recommendations are conditioned by deep mechanistic studies.

show abstract

“…3-Nitroaniline and 4nitroaniline are used as reference compounds for optical nonlinearity [1][2][3] calculated by computational and experimental method. 3-Nitroaniline and its derivatives are biologically important compounds, such compounds are produced signi cant antihyperglycemic as well as hypoglycemic effects in alloxan-induced and normal diabetic rabbits [4]. Also m-Nitroaniline plays an essential role in several biological processes and has considerable chemical and pharmacological importance.…”

Section: Introductionmentioning

confidence: 99%

Structural, vibrational, quantum chemical calculations, thermal and antimicrobial studies on nitrate salt of 3-nitroaniline

et al. 2021

View full text Add to dashboard Cite

In this work, 3-nitroanilinium nitrate (3NAN) has been synthesized and crystallized successfully by solution growth combined with solvent evaporation technique. 3NAN molecular structure has been optimized with Density Functional Theory (DFT) using B3LYP function and Hartree-Fock method with a 6-311 + + G(d,p) basis set. The geometrical parameters of the title molecules have been analyzed. The computed vibrational spectra were compared with experimental result which show appreciable agreement. Thermal stability of the crystal was analyzed with TGA/DTA and the melting points of the salt identi ed at 209 ºC. HOMO-LUMO energy calculations have shown the charge transfer within the molecu le. The possible pharmaceutical/biological activity of the salts con rmed by the Frontier Molecular Orbital (FMO) analysis have lower band gap value. The antimicrobial activity of grown crystals were tested against certain potentially threatening microbes.

show abstract

Hypoglycemic and antihyperglycemic effects of newly synthesized sulfonyloxy derivatives of azalactone in normal and alloxan diabetic rabbits

Cited by 9 publications

References 1 publication

A triclinic polymorph of 3-nitroanilinium chloride

A triclinic polymorph of 3-nitroanilinium chloride

Evaluation of Safety of Stewart’s Wood Fern (Dryopteris stewartii) and Its Anti-Hyperglycemic Potential in Alloxan-Induced Diabetic Mice

Structural, vibrational, quantum chemical calculations, thermal and antimicrobial studies on nitrate salt of 3-nitroaniline

Contact Info

Product

Resources

About