Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits

Oleuropein using as an Additive for Feed and Products used for Humans

“…In diabetes mellitus, various hypoglycemic agents reduce oxidative stres indirectly by lowering blood glucose level and preventing hyperinsulinemia and directly by acting as free radical scavengers. Oleuropein has been reported with an effective hypoglycemic action in diabetic animals [9]. One of the other compounds responsible for hypoglycemic activity was oleuropeoside, which showed activity at a dose of 16 rug/kg.…”

“…It is a phenolic compound which has been shown to possess diverse healing properties for its vasodilatory [1], hypotensive [2,3], anti-inflamatory [4], antirheumatic [5], diuretic [6], anti-atherogenic [7] and antipyretic [8] effects. Most of these pharmacologic features of oleuropein ( Figure 1) are due to its potent antioxidant action [9].…”

Filamentous fungi as a source of natural antioxidants

“…It is possible that the high activity associated with the fungal antioxidants is a consequence of a high manifestation of phenolic compounds in the extracted fungal mycelia. Phenolic compounds can act as antioxidants in many ways and in relevant literature, have been found to chelate to metal ions, prevent radical formation and improve the antioxidant endogenous system (Al-Azzawie & Alhamdani, 2006). This is significant as metal ions are proposed as the catalysts for the initial formation of reactive oxygen species.…”

Comparison of 1% cyclosporine eye drops in olive oil and in linseed oil to treat experimentally-induced keratoconjunctivitis sicca in rabbits

“…Olive oil, from the fruit of the olive tree Olea europaea, contains a significant concentration of monounsaturated fatty acids (MUFAs), of which 70-80% are oleic acid, in addition to 10-15% saturated fatty acids (palmitic acid) and 5-10% omega 3 (ω-3), 6 (ω-6), and 9 (ω-9) polyunsaturated fatty acids (PUFAs) (8) . Olive oil has been shown to possess antinociceptive, anti-inflammatory, antiarrhythmic, spasmolytic, immunostimulant, cardioprotective, hypotensive, hypoglycemic, and antimicrobial properties (9)(10)(11) . Linseed oil, from the flax plant Linum usitatissimum, is composed of 57% ω-3, 16% ω-6, 28% MUFA, and only 9% unsaturated fatty acids; the ω-3-to-ω-6 ratio of 1:3 is considered to be close to ideal (12) .…”