Hypoglycemic and Antioxidant Effects of Subcoriacin in Normal and Streptozotocin-induced Diabetic Rats

Abstract

Subcoriacin (1) is a 3-aryl-6-prenylcoumarin isolated from Eysenhardtia subcoriacea that has shown antioxidant activity in vitro, and has shown to scavenge free radicals and also to improve the reduced glutathione levels in pancreatic homogenates. The present investigation evaluates the protective effect of 1 against oxidative injury in normal and streptozotocin (STZ)-induced diabetic rats. The i.p. administration of 1 at a dose of 100 mg/kg body weight for 5 d, significantly decreased blood glucose levels and improved the endogenous antioxidant system. Also, a significant increase in the activities of the antioxidant enzymes glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) occurred. Combined treatment of rats with 1 (100 mg/kg) and STZ significantly reduced the pancreatic levels of thiobarbituric acid reactive substances (TBARS) levels. Likewise, significant increases in the activities of the antioxidant enzymes together with a decrease in blood glucose levels in both treatments were observed. The results demonstrate and support the relationship between the hypoglycemic and antioxidant activities displayed by the natural compound 1.

An antioxidant activity of Cinnamonum tamala improves histopathological alterations and biochemical parameters in alloxan induced diabetic rats

“…Diabetes mellitus is currently a major public health concern, because its incidence and prevalence are elevated and increasing, reaching epidemic proportions. 27 Cumulative evidence has shown that poorly and erratically controlled hyperglycemia produces abnormally high levels of ROS, 28 and these reactive substances could react with essential molecules such as lipids, proteins and DNA, leading to histological changes as well as functional alterations. 29 Diversity of medicinal plants and spices containing various phytochemicals with biological activity serve as viable source of drugs for the world population.…”

Hypoglycemic and Hepatoprotective Activities of Coriander (Coriandrum sativum) Extract in Streptozocin Induced Diabetic Rats

“…STZ induced hyperglycemia in models was previous used" by Vasconcelos et al [101]. STZ induces hyperglycemia in experimental animals and used to induce diabetes in rats" [102]. "Intraperitoneal injection of STZ increased plasma glucose level gradually to reach its maximum level within 14 days.…”