Hypoglycemic and hypolipidemic effect of Allopolyherbal formulations in streptozotocin induced diabetes mellitus in rats

Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas

“…Treatment with synthetic drugs causes side effects such as gastrointestinal disturbances, hypoglycemia, rise in hepatic enzymes, and hematological diseases. Management of diabetes without side effects is a hard challenge to the medical community [9]. Another problem in administering these synthetic therapeutic drugs is that their dynamic role in achieving glycemic control is unsuccessful [10].…”

The Effects of Curcumin on Alpha Amylase in Diabetics Rats

“…It is a serious endocrine syndrome with poor metabolic control and responsible for increased risk of diseases such as atherosclerosis, renal failure, blindness or diabetic cataract [3][4][5]. Diabetes mellitus is one of the most common endocrine disorders and is characterized by hyperglycemia, hypercholesterolemia and hypertriglyceridemia, resulting from defects in insulin secretion or reduced sensitivity of the tissue to insulin (insulin resistance) and/or combination of both [6,7]. Different types of oral antidiabetic agents such as biguanides and sulphonylurea are available along with insulin for the treatment of diabetes mellitus, but have side effects associated with their uses [8].…”

Antihyperglycemic Activity of Phenyl and Ortho-Hydroxy Phenyl Linked Imidazolyl Triazolo Hydroxamic Acid Derivatives

“…Group 2 to group 13 was treated orally with the suspension of (FP1-FP12) at a dose of 100 mg/kg, per os and group 14 (positive control) was treated with standard glibenclamide (600µg/kg) [10]. A blood sample was withdrawn from the retro-orbital plexus at 0 h, 2 h, 4 h, 6 h, 8 h, 24 h of glucose administration and blood glucose levels were estimated within 1 h, by glucose oxidase-peroxidase method [11].…”