Hypoglycemic and Hypolipidemic Effects ofAloe veraExtract Preparations: A Review

Abstract

Obesity is considered to be an epidemic disease, and it is associated with several metabolic disorders. Pharmacological treatments currently available are not effective for prolonged treatment duration. So, people are looking toward new therapeutic approach such as herbal ingredients. Since ancient periods, different herbs have been used for remedy purposes such as anti-obesity, antidiabetes, and antiinflammatory. Among the several herbal ingredients, Aloe vera (Aloe barbadensis Miller) is widely used to curb the metabolic complications. Till date, reports are not available for the side effects of A. vera. Several researchers are used to different solvents such as aqueous solution, alcohol, ethanol, and chloroform for the A. vera extract preparations and studied their hypoglycemic and hypolipidemic effects in animal and human studies. Furthermore, little information was recorded with the active compounds extracted from the A. vera and their anti-obesity and antidiabetic effects in clinical studies. In this review, we made an attempt to compile all the available literature by using different search engines (PubMed, Scopus, and Google Scholar) on the A. vera extract preparations and the possible mechanism of action involved in carbohydrate and lipid metabolism.

Aloe vera as an herbal medicine in the treatment of metabolic syndrome: A review

“…The energy balance in the body is achieved through the equation of the amount of energy supplied through food and energy consumed in the body. Excess food energy can be stored in the adipose tissue as TG, used in physical activity, or convert into thermal energy (Pothuraju, Sharma, Onteru, et al, ). In obesity, energy imbalance leads to several metabolic disorders, including insulin resistance, type II diabetes mellitus, retinopathy, neuropathy, nephropathy, and cardiopathy (Al‐Goblan, Al‐Alfi, & Khan, ).…”

“…vera play a role in lowering the blood lipid levels. They have nonextensive intestinal absorption; however, they can bind to the cholesterol and prevent its absorption (Pothuraju, Sharma, Onteru, et al, ).…”

“…vera species have different applications. In this regard, they are utilized for their antiulcer (Suvitayavat, Sumrongkit, Thirawarapan, & Bunyapraphatsara, ), antihyperlipidemic (Pothuraju, Sharma, Onteru, Singh, & Hussain, ), antifungal (Saniasiaya, Salim, Mohamad, & Harun, Jan), antiviral (Alves, Perez‐Fons, Estepa, & Micol, ), antimicrobial (Ferro et al, ), anticancer (El‐Shemy et al, ), antioxidant (Boudreau & Beland, ), burn wound healing (Choi & Chung, ), antidiabetic (Pothuraju, Sharma, Onteru, et al, ), immunomodulator (Pugh, Ross, ElSohly, & Pasco, ), antihypertensive (Saleem et al, ), antiobesity (Misawa et al, ), and hepatoprotective effects (Chandan et al, ). Moreover, A .…”

Optimizing the incorporation of aloe vera in yacon (smallanthus sonchifolius poepp. & endl.) Through vacuum impregnation using response surface

“…Aloe vera gel contains mainly polysaccharides, phenolic compounds, organic acids, enzymes, vitamins, and minerals [9]. Moreover, acemannan, a partially acetylated polysaccharide found in Aloe vera gel, is responsible for biological activities [10], [11], [8].…”

“…Yacon consumption is correlated with human health benefits, such as hypoglycemic effects [3], [4], antioxidant activity [5], and potential chemoprevention against colon carcinogenesis [6]. Another product of interest is Aloe vera, which has a long history of use in the promotion of health, being one of the herbal remedies most frequently used throughout the world [7], [8]. Aloe vera gel contains mainly polysaccharides, phenolic compounds, organic acids, enzymes, vitamins, and minerals [9].…”