Hypoglycemic and Other Related Effects of Elephantopus scaber Extracts on Alloxan Induced Diabetic Rats

Daisy, P.; Rayan, Anwar; ., D. Rajathi

doi:10.3923/jbs.2007.433.437

Cited by 22 publications

(8 citation statements)

References 9 publications

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“…In addition, the water extract was found to be noncytotoxic on this cell line as it displayed low growth inhibition at all concentrations used. Although the water extract is traditionally used for preparation of decoction or infusion of this plant and has been reported to possess anti-inflammatory and antidiabetic effects, 36,37 it was found to have a low efficiency in extracting anticancer agents from this plant. Thus, the ethyl acetate extract was selected for further cytotoxicity analysis in different cell lines and incubation times.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation

et al. 2012

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Previous cytotoxic (anticancer) evaluations of Elephantopus mollis were mainly focused on its elephantopin derivatives neglecting the combined effect of the phytochemicals in its traditionally used extracts. In this study, the cytotoxic mechanism of its extracts was investigated using methylene blue assay. The cytotoxic screening results revealed the ethyl acetate extract as the most potent extract by displaying prominent dose-dependent and time-dependent growth inhibitions in human liver carcinoma HepG2 cells with the lowest EC 50 value of 9.38 ± 0.43 µg/mL after 72 hours of treatment. Acute exposure of the HepG2 cells to the ethyl acetate extract produced a significant regulation of caspase-3 with the peak expression at 8 hours of treatment (P < .05). DNA fragmentation indicated by DeadEnd Apoptosis Detection System-labeled nuclei cells confirmed that the extract induced apoptotic cell death through caspase-3-dependent pathway in HepG2 cells.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation

et al. 2012

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“…The extract GLBF was showed significantly increased the total protein and lowered the serum urea and creatinine levels by enhancing the renal function that is generally impaired in diabetic rats. This result is going with a previous study (Daisy et al, 2007).…”

Section: Discussionmentioning

confidence: 82%

“…Lycium barbarum L. (Solanaceae) is widely distributed in Iraq. This plant is well known in Arabic and English system as 'Ausaj, Osaj, Sarim' and 'Box Thorn, Matrimony-Vine', respectively (Chakravarty, 1976). Information gathered from some herbalists (in Basra governorate, Iraq) that the plant is useful to reduce blood sugar, blood cholesterol, rheumatism, heart and liver ailments, infant convulsions and also to aid digestion and to preventing and treating cancer, hepatitis, hypo-immunity function.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Al–Fartosy

2015

American Journal of Biochemistry and Biotechnology

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Lycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found to be non-toxic at 1000 mg kg −1 , as no deaths or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice. In GLBF (500 mg kg −1 ), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In the chronic study, repeated administration (once a day for 21 days) of the glibenclamide and GLBF caused a significant reduction in the serum glucose level as compared to the diabetic control group. GLBF (500 mg kg −1 ) treatment prevented a decrease in the body weight of the diabetic rats. Moreover, the results revealed that GLBF (500 mg kg −1 ) treatment for 21 days significantly (p<0.01) reduced the levels of lipid profile, lipid peroxidation, improving kidney and liver functions, enhanced insulin level and increased the levels of enzymatic and non-enzymatic antioxidants. The findings in this study suggest that polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) possess good pharmacological activities, which might be helpful in controls the blood glucose level, improves body weight, lipid metabolism and prevents diabetic complications associated with lipid peroxidation and also maintains the antioxidant enzymatic and nonenzymatic in experimental diabetic rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus.

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“…Diabetes mellitus is a chronic disease characterized by hyperglycemia, alteration in fat and protein metabolism. Injection of chemical drugs used to treat hyperglycemia can cause side effects such as hypoglycemia, coma and liver and kidney damage (25). The antidiabetic activity of the aqueous extract of ES roots and leaves given at a concentration of 0.3 / kg body weight for 12 weeks resulted in a decrease in blood glucose.…”

Section: Anti-diabetes Mellitusmentioning

confidence: 99%

Utilization of Elephantopus scaber as traditional medicine and its bioactivity

Silalahi¹

2021

GSC Biol. and Pharm. Sci.

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Elephantopus scaber has been used various ethnic groups in Indonesia and other countries as traditional medicine. Comprehensive study of the bioactivity of E. scaber is still limited, therefore this paper aims to explain the relationship between the use and its bioactivity. The writing of this article is based on a study of literature published online and offline used keywords E. scaber, bioactivities of E. scaber and uses of E. scaber. Ethnobotanically, E. scaber used to tread wound, nephritis, edema, chest pain, fever, scabies, sores, coughs, tonics, fever, and bronchitis, and asthma. The local communities in China, E. scaber leaves have been developed into "tea" to cure various diseases. The bioactivity of E. scaber is anti-bacterial, anti-fungal, anticancer, hepatoprotective, stimulates hair growth, anti-diabetes mellitus, anti-wound, antioxidant, and overcoming kidney disorders. Deoxyelephantopin is one of the main sesquiterpenes lactones derived from E. scaber has anti-cancer anticancer development. The development of E. scaber tea as an anti-cancer needs to be further investigated because this plant is very easy to find in Indonesia.

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Hypoglycemic and Other Related Effects of Elephantopus scaber Extracts on Alloxan Induced Diabetic Rats

Cited by 22 publications

References 9 publications

Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation

Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Utilization of Elephantopus scaber as traditional medicine and its bioactivity

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