Hypoglycemic bioactivity of anthocyanins: A review on proposed targets and potential signaling pathways

Li, Zhiying; Tian, Jinlong; Cheng, Zhen; Teng, Wei; Zhang, Weijia; Bao, Yiwen; Wang, Yidi; Song, Baoge; Chen, Yi; Li, Bin

doi:10.1080/10408398.2022.2055526

Cited by 24 publications

(14 citation statements)

References 128 publications

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“…In addition, anthocyanins play a protective role in cardiovascular diseases through the increment of PPAR and the downregulation of CD36 expression to prevent platelet aggregation and LDL oxidation; moreover, anthocyanins increase polyunsaturated fatty acid levels over saturated fatty acid levels [ 12 , 16 , 17 , 18 ]. Furthermore, these pigments have hypoglycemic and anti-obesity properties by increasing GLUT4 expression through AMPK activation leading to better glucose catchment by muscles and fat tissue [ 19 , 20 ]. Furthermore, anthocyanins decrease PEPCK expression and upregulate PPAR, CPT1A, and ACO, providing a reduction in lipid liver levels [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Stabilization of Anthocyanins from Coffee (Coffea arabica L.) Husks and In Vivo Evaluation of Their Antioxidant Activity

et al. 2023

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Coffee (Coffea arabica L.) is one of the most popular and widely consumed products throughout the world, mainly due to its taste, aroma, caffeine content, and natural antioxidants. Among those antioxidants, anthocyanins are one of the most important natural pigments, which can be found in coffee husks. It is widely known that anthocyanins have multiple health benefits partially linked to their antioxidant properties. However, anthocyanins have low stability and are sensitive to all types of changes. In order to prevent its degradation, anthocyanins can be stabilized with nanoparticles. Thus, the main objective of this study was to evaluate the stability of the anthocyanins extracted from coffee husks, using three different extracting agents (ethanol, methanol, and water) and stabilizing them through conjugation with zinc oxide nanoparticles. The anthocyanins extracts were mainly composed of cyanidin-3-rutinoside (97%) and the total phenolic compounds of the fresh extracts were 458.97 ± 11.32 (methanol), 373.53 ± 12.74 (ethanol), and 369.85 ± 15.93 (water) mg GAE/g. On the other hand, the total phenolic compounds of the nanoparticle–anthocyanin conjugates underwent no significant changes after stabilization as the major loss was less than 3%. Furthermore, the percentage of anthocyanins’ degradation was less than 5% after 12 weeks of storage. On top of that, fresh anthocyanin extracts and anthocyanin–nanoparticle conjugates exhibited a strong protective effect against oxidative stress and increased the survival rate of Caenorhabditis elegans.

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Section: Introductionmentioning

confidence: 99%

Stabilization of Anthocyanins from Coffee (Coffea arabica L.) Husks and In Vivo Evaluation of Their Antioxidant Activity

et al. 2023

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Section: Introductionmentioning

confidence: 99%

“…Diabetes mellitus (DM) is a common endocrine metabolic disorder accompanied by glucose, fat, and protein metabolism disorders caused by insulin secretion and/or functional deficiencies. 1 The global prevalence of DM is growing rapidly, and the number of patients with diabetes is estimated to be 463 million in 2019, which is expected to increase to 578 million by 2030 and 700 million by 2045. 2 Without effective treatment, diabetes mellitus (DM) will result in severe complications in various body tissues or organs, such as liver dysfunction, renal failure, blindness, and nervous system damage.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Mechanism of Prenylated Flavonoids Isolated from Mulberry Leaves on α-Glucosidase by Multi-Spectroscopy and Molecular Dynamics Simulation

Tian

Zhao

et al. 2023

J. Agric. Food Chem.

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Flavonoids have always been considered as the chemical basis for the hypoglycemic effect of mulberry leaves. In the course of our search for hypoglycemic effect agents from natural sources, a systematic study was launched to explore prenylated flavonoids from mulberry leaves. Herein, chemical investigation led to the isolation of 10 characteristic prenylated flavonoids, including two new compounds (1 and 3). Their structures were elucidated based on spectroscopic data. All compounds exhibited good α-glucosidase inhibitory activity in vitro, among which compound 2 had the best activity (IC 50 = 2.6 μM), better than acarbose (IC 50 = 19.6 μM). Additional in vivo tests have further demonstrated compound that compound 2 has a good ability to reduce postprandial blood glucose. Then, multi-spectroscopic methods and molecular simulation studies were used to study the inhibition mechanism. The results showed that compound 2 was a mixed inhibition of α-glucosidase and the binding process was spontaneous, with van der Waals forces as the main driving force, followed by hydrogen bonding and electrostatic forces. The above studies enriched the chemical basis of mulberry leaves, and the application of computational chemistry also provided a reference for future research on such structures.

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“…Diabetes consists of two major subtypes, type 1 and type 2, where type 2 diabetes (T2D) makes up about 90% of the cases ( 1 ). The outstanding character of T2D is the systemic metabolic disturbances including elevated blood glucose and lipid content level ( 2 , 3 ). Glucose toxicity ( 4 , 5 ) and lipid toxicity ( 6 , 7 ) are the two major metabolic insults to those energy-demanding organs such as the heart.…”

Section: Introductionmentioning

confidence: 99%

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis

Liu

Wen

et al. 2022

Front. Cardiovasc. Med.

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Changes in modern lifestyle provoke a series of metabolic stresses such as hyperlipidemia. Excessive free fatty acids induce cardiomyocyte metabolic reprogramming and rearrangement of the lipid content of cardiomyocyte and promote oxidative stress. As a newly defined lipid peroxidation-related cell death pathway, the role of ferroptosis in metabolic stress-induced cardiomyocyte injury is poorly revealed. Our work indicates that GSK-J4, a histone lysine demethylase 6A/6B dual inhibitor, can alleviate palmitic acid (PA)-induced hypersensitivity to ferroptosis by suppressing H3K27 demethylation. Mechanistically, PA stimulation reduces the H3K27me3 level and hence promotes the expression of ACSL4, a key lipid modulator of ferroptosis. GSK-J4 pretreatment significantly preserves the H3K27me3 level and reduces the ACSL4 level. GSK-J4 also reduces reactive oxygen species to alleviate oxidative stress, which further decreases lipid peroxidation. Taken together, our data suggest that cardiomyocyte undergoes epigenetic reprogramming under metabolic challenges, rearranging lipid content, and sensitizing to ferroptosis. GSK-J4 can be a potential drug for treating hyperlipidemia-induced cardiomyocyte injury by targeting epigenetic modulations.

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Hypoglycemic bioactivity of anthocyanins: A review on proposed targets and potential signaling pathways

Cited by 24 publications

References 128 publications

Stabilization of Anthocyanins from Coffee (Coffea arabica L.) Husks and In Vivo Evaluation of Their Antioxidant Activity

Stabilization of Anthocyanins from Coffee (Coffea arabica L.) Husks and In Vivo Evaluation of Their Antioxidant Activity

Inhibitory Mechanism of Prenylated Flavonoids Isolated from Mulberry Leaves on α-Glucosidase by Multi-Spectroscopy and Molecular Dynamics Simulation

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis

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