Hypoglycemic effect of a leaf extract of Pseuderanthemum palatiferum (Nees) Radlk. in normal and streptozotocin-induced diabetic rats

Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats

“…The obtained results of the anti-hyperglycemic and anti-hyperlipedemic effects of the extract from H.cordata in the present study are in accordance with the effects of various plant extracts and/or plant products such as the 80% ethanolic extract of Pseuderanthemum palatiferum at a dose of 250 mg/kg b.w administered daily and orally to the diabetic rats for 14 days showed hypoglycemic activity by significantly (p<0.05) decreasing levels of fasting plasma glucose (FPG) compared to that in normal controls, 25 the leaf extract from Mimosa pudica which showed high hypo-lipidemic activity by significant (p<0.05) decreasing serum cholesterol, triglyceride and LDL levels, but increasing HDL level when compared to those positive controls (standard drug), 26 the ethanol extract from the whole plant of Mimosa pudica which showed a significant hypo-lipidemic effect by decreasing the lipid profiles such as cholesterol, triglyceride and LDL levels but increasing in HDL level in the serum which was similar to the standard drug. 27 These results were also similar to the ethanolic extract of the aerial part of Salvadora oleoides Decne which produced a significant reduction (p<0.001) in blood glucose and also had beneficial effects ( P<0.001) on the lipid profile in euglycemic as well as alloxan-induced diabetic rats, although the reduction in the blood glucose and improvement in lipid profile was less than that achieved with the standard drug tolbutamide.…”

Protective effect of berberine on serum glucose levels in non-obese diabetic mice

“…Researches on oral hypoglycemic agents from foods, natural plants and traditional medicine for the treatment of T2D are blooming [9][10][11]. Berberine has recently shown hypoglycemic and insulin-sensitizing effects in high-fat diet-and streptozotocin-induced diabetic rats [6].…”

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

“…38 These results demonstrate that the recipe could be improve renal and liver damage 39,40 The renal dysfunction improvement could be justified by total protein increasing, as in diabetic individuals nephropathy is the main factor for protein excretion in urine. [41][42][43][44] Diabetes has been a great influence on lipid metabolism caused by streptozotocin-induced as a result to increasing of TC and TG levels which observed by impaired with liver function from diabetic rat damage. [44][45] Our data showed improvement of lipid profiles which increased HDL, decreased TC, TG and LDL in the diabetic rats.…”

“…[44][45] Our data showed improvement of lipid profiles which increased HDL, decreased TC, TG and LDL in the diabetic rats. 15,16,41 The plants could be prevent and treat disorders of diabetes which mainly responsible for mediating the formation by peroxi-dation of unsaturated fatty acids, cholesterol and lipoproteins, increased lipid peroxidation leads to membrane damage and consequently organs dysfunction being this an important risk factor for atherosclerosis and coronary artery disease. 44,46,[48][49] Decreasing on lipid levels and consequently the reduction of lipid peroxidation were improved due to the high antioxidant potential of polyphenolic compounds that act by mechanisms of reaction inhibition in the peroxidation chain and could be reduce complication resulting from diabetes.…”