Hypoglycemic effect of a novel polysaccharide from<i>Lentinus edodes</i>on STZ-induced diabetic mice<i>via</i>metabolomics study and Nrf2/HO-1 pathway

Wang, Xiaojuan; Gong, Pin; Li, Meng; wang, menrao; wang, siyuan; Guo, Yuxi; Chang, Xiangna; Yang, Wenjuan; Chen, Xuefeng; Chen, FuXin

doi:10.1039/d1fo03487a

Cited by 20 publications

(12 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many edible fungi polysaccharides, including Ganoderma lucidum , Lentinus edodes , and Cordyceps militaris , have been reported to have hypoglycemic effects [ 22 , 23 , 24 ], while these researches mainly focus on the activities of polysaccharides themselves. Some studies have compared the hypoglycemic activities of polysaccharides from different sources, but the reasons for the differences have not been clarified.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic Effect of Edible Fungi Polysaccharides Depends on Their Metabolites from the Fermentation of Human Fecal Microbiota

Yu,

Luo,

Liu

et al. 2023

Foods

View full text Add to dashboard Cite

Edible fungi polysaccharides are widely sourced and have various physiological activities, including hypoglycemic. Current studies mainly focus on the hypoglycemic activity of polysaccharides themselves, while the strength of the hypoglycemic activity of edible fungi polysaccharides from different sources remained elusive. This study compared the hypoglycemic activity of different edible fungi polysaccharides after in vitro fermentation by fecal bacteria, combined with non-targeted metabolomics and 16S rDNA analysis, to screen out potential key metabolites related to the hypoglycemic activity. The results show that the fermentation supernatants of all four edible fungi polysaccharides significantly increased the glucose consumption and glycogen synthesis of IR-HepG2, also up-regulated the level of hexokinase and down-regulated the level of phosphoenolpyruvate carboxylase. All fermentation supernatants could alleviate the insulin resistance of IR-HepG2 cells by regulating the expression levels of genes related to the IRS-1/PI3K/Akt signaling pathway. Gingerglycolipid A, sphinganine 1-phosphate, matricin, tricarballylic acid, N-carbamoylputrescine, nomega-acetylhistamine, tyramine, and benzamide could be considered as potential key metabolites to evaluate the hypoglycemic effects. Their levels were strongly positively correlated with the abundance of Candidatus_Stoquefichu, Faecalibacterium, Coprococcus, Bacteroides, Eubacterium_ventriosum_group, Anaerostipes, Parabacteroides, and Agathobacter. These metabolites and microorganisms are closely related to the hypoglycemic activity of edible fungi polysaccharides.

show abstract

Section: Discussionmentioning

confidence: 99%

Hypoglycemic Effect of Edible Fungi Polysaccharides Depends on Their Metabolites from the Fermentation of Human Fecal Microbiota

Yu,

Luo,

Liu

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…Mushroom bioactive compounds have also been found to have anti-inflammatory and anti-oxidant properties, which may contribute to their anti-senescence effects [ 212 ]. For example, polysaccharides from Lentinus edodes (shiitake mushroom) have been shown to reduce oxidative stress and inflammation in aging mice, which may help delay the accumulation of senescent cells [ 78 , 213 , 214 ]. Overall, mushroom bioactive compounds have shown promise as potential interventions to delay or mitigate the accumulation of senescent cells and promote healthy aging through various mechanisms.…”

Section: Molecular and Cellular Mechanisms Underlying Aging Processesmentioning

confidence: 99%

Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms

Luo,

Ganesan,

2024

JoF

View full text Add to dashboard Cite

Aging is a complex biological process that is influenced by both intrinsic and extrinsic factors. Recently, it has been discovered that reactive oxygen species can accelerate the aging process, leading to an increased incidence of age-related diseases that are characteristic of aging. This review aims to discuss the potential of mushrooms as a dietary intervention for anti-aging, focusing on their nutritional perspective. Mushrooms contain various bioactive compounds, including carbohydrates, bioactive proteins, fungal lipids, and phenolic compounds. These compounds have shown promising effectiveness in combating skin aging and age-related diseases. In vitro and in vivo studies have demonstrated that treatments with mushrooms or their extracts can significantly extend lifespan and improve health span. Furthermore, studies have aimed to elucidate the precise cellular and molecular mechanisms of action and the structure–activity relationship of mushroom bioactive compounds. These findings provide a strong basis for further research, including human clinical trials and nutritional investigations, to explore the potential benefits of mushrooms in real-life anti-aging practices. By exploring the anti-aging effects of mushrooms, this review aims to provide valuable insights that can contribute to the development of broader strategies for healthy aging.

show abstract

“…Glucose metabolism is closely related to lipid metabolism. Thus, diabetes in mice is usually accompanied by a disorder of lipid metabolism, characterized by higher serum levels of TG, TC, and LDL-c and lower level of HDL-c. 40 Functional lesions in liver tissue and their complications, such as liver enlargement, fibrosis, and steatosis, are usually observed in diabetic mice. 41 Significant increases in serum and hepatic lipid levels after HSHF/STZ treatment.…”

Section: Food and Function Papermentioning

confidence: 99%

Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus

et al. 2023

View full text Add to dashboard Cite

show abstract

Hypoglycemic effect of a novel polysaccharide fromLentinus edodeson STZ-induced diabetic miceviametabolomics study and Nrf2/HO-1 pathway

Abstract: With the increased worldwide prevalence of diabetes, more and more attentions are focused on the natural drug candidate who could treat diabetes with high efficacy but without undesired side effect....

Cited by 20 publications

References 76 publications

Hypoglycemic Effect of Edible Fungi Polysaccharides Depends on Their Metabolites from the Fermentation of Human Fecal Microbiota

Hypoglycemic Effect of Edible Fungi Polysaccharides Depends on Their Metabolites from the Fermentation of Human Fecal Microbiota

Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms

Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus

Contact Info

Product

Resources

About