Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats

Andrade‐Cetto, Adolfo; Wiedenfeld, Helmut

doi:10.1016/s0378-8741(01)00335-x

Cited by 193 publications

(151 citation statements)

References 7 publications

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“…Our ethnopharmacological studies according to our previous ones (Andrade-Cetto et al, 2000;Andrade-Cetto and Wiedenfeld, 2001) in San Felipe Usila, Oaxaca, proved this report and showed that the plant is used traditionally for the treatment of diabetes type II.…”

Section: Introductionsupporting

confidence: 71%

Pyrone Glycosides from Acosmium panamense (Benth.) Yacovlev

Wiedenfeld

Andrade‐Cetto

2003

Zeitschrift Für Naturforschung C

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Section: Introductionsupporting

confidence: 71%

Pyrone Glycosides from Acosmium panamense (Benth.) Yacovlev

Wiedenfeld

Andrade‐Cetto

2003

Zeitschrift Für Naturforschung C

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“…Chlorogenic acid is partly absorbed by the body [49], and metabolic effects in humans have been shown [50]. In a study in streptozotocin diabetic rats, oral administration of chlorogenic acid reduced plasma glucose levels over a 3-h period [51]. Chlorogenic acid may reduce hepatic glucose output through inhibition of glucose-6-phosphatase activity [15], may attenuate glucose absorption rates by inhibiting the sodium-dependent glucose transporters [14], and may reduce oxidative stress through its anti-oxidant properties [14].…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

Dam¹,

et al. 2004

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Aims/hypothesis. Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee consumption and the incidence of IFG, IGT and type 2 diabetes. Methods. We used cross-sectional and prospective data from the population-based Hoorn Study, which included Dutch men and women aged 50-74 years. An OGTT was performed at baseline and after a mean follow-up period of 6.4 years. Associations were adjusted for potential confounders including BMI, cigarette smoking, physical activity, alcohol consumption and dietary factors. Results. At baseline, a 5 cup per day higher coffee consumption was significantly associated with lower fasting insulin concentrations (−5.6%, 95% CI −9.3 to −1.6%) and 2-h glucose concentrations (−8.8%, 95% CI −11.8 to −5.6%), but was not associated with lower fasting glucose concentrations (−0.8%, 95% CI −2.1 to 0.6%). In the prospective analyses, the odds ratio (OR) for IGT was 0.59 (95% CI 0.36-0.97) for 3-4 cups per day, 0.46 (95% CI 0.26-0.81) for 5-6 cups per day, and 0.37 (95% CI 0.16-0.84) for 7 or more cups per day, as compared with the corresponding values for the consumption of 2 or fewer cups of coffee per day (p=0.001 for trend). Higher coffee consumption also tended to be associated with a lower incidence of type 2 diabetes (OR 0.69, CI 0.31-1.51 for ≥7 vs ≤2 cups per day, p=0.09 for trend), but was not associated with the incidence of IFG (OR 1.35, CI 0.80-2.27 for ≥7 vs ≤2 cups per day, p=0.49 for trend). Conclusions/interpretation. Our findings indicate that habitual coffee consumption can reduce the risk of IGT, and affects post-load rather than fasting glucose metabolism.

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“…Some flavonoids such as rutin, quercetin (Figure 2A), isoorientin, 3-caffeoylquinic acid (chlorogenic acid), and silibin isoform 3 (obtained of milk thistle) have hypoglycemic properties [63][64][65][66][67].…”

Section: Flavonoidsmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats

Cited by 193 publications

References 7 publications

Pyrone Glycosides from Acosmium panamense (Benth.) Yacovlev

Pyrone Glycosides from Acosmium panamense (Benth.) Yacovlev

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

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