Hypoglycemic Effect of Chinese Yam (<i>Dioscorea opposita rhizoma</i>) Polysaccharide in Different Structure and Molecular Weight

Li, Qian; Li, Wenzhi; Gao, Qunyu; Zou, Yu-Xiao

doi:10.1111/1750-3841.13919

Cited by 64 publications

(19 citation statements)

References 38 publications

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“…Furthermore, many herbs in the Chinese Pharmacopeia enriched in fibers and botanicals are also present in our daily diet and are named herbal food supplements (Di Giorgi Gerevini et al, 2005 ). For example, Momordica charantia and Chinese yam are common foods in the daily diet and are also used as HMs to treat diabetes and modulate gut microbiota (Li et al, 2017 ; Wang et al, 2017 ). Diet is intimately associated with T2DM, and gut microbiota is considered an intersection of diet and disease (Sonnenburg and Backhed, 2016 ).…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Zheng

Gou

Zhang

et al. 2020

Front. Cell. Infect. Microbiol.

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Herbal medicines (HMs) are a major subset of complementary and alternative medicine. They have been employed for the efficient clinical management of type 2 diabetes mellitus (T2DM) for centuries. However, the related underlying mechanisms still remain to be elucidated. It has been found out that microbiota is implicated in the pathogenesis and treatment of T2DM. An interplay between gut microbiota and host occurs mainly at the gastrointestinal mucosal barrier. The host movements influence the composition and abundance of gut microbiota, whereas gut microbiota in turn modulate the metabolic and immunological activities of the host. Intestinal dysbiosis, endotoxin-induced metabolic inflammation, immune response disorder, bacterial components and metabolites, and decreased production of short-chain fatty acids are considered significant pathogenic mechanisms underlying T2DM. The interaction between gut microbiota and HMs during T2DM treatment has been investigated in human, animal, and in vitro studies. HMs regulate the composition of beneficial and harmful bacteria and decrease the inflammation caused by gut microbiota. Furthermore, the metabolism of gut microbiota modulates HM biotransformation. In this review, we have summarized such research findings, with the aim to improve our understanding of the pathogenesis and potential therapeutic mechanisms of HMs in T2DM and to provide new insights into specific targeted HM-based therapies and drug discovery.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Zheng

Gou

Zhang

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Chinese yam tubers and extracts have been shown to reduce serum levels of low-density lipoprotein (LDL) cholesterol and inhibit fat absorption in rodents, alleviating hypertension and attenuating obesity caused by a high-fat diet (Chen et al 2003 ; Kwon et al 2003 ; Liu et al 2009 ; Amat et al 2014 ; Gil et al 2015 ). There is also evidence that the tubers reduce the incidence of diabetes (Gao et al 2007 ; Hsu et al 2007 ; Fan et al 2015 ; Li et al 2017 ), possibly reflecting their ability to inhibit α-glucosidase activity (Zhang et al 2011 ). Chinese yam tubers are rich in antioxidants (Chiu et al 2013 ) and have a positive effect on the immune system (Choi et al 2004 ; Hou and Jin 2012 ) which is probably linked to their ability to modulate inflammation (Jin et al 2011 ; Gil et al 2015 ).…”

Section: Chinese Yam Ingredients With Health Benefits and Other Usefumentioning

confidence: 99%

An underutilized orphan tuber crop—Chinese yam : a review

Epping¹,

Laibach

2020

Planta

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Main conclusion The diversification of food crops can improve our diets and address the effects of climate change, and in this context the orphan crop Chinese yam shows significant potential as a functional food. Abstract As the effects of climate change become increasingly visible even in temperate regions, there is an urgent need to diversify our crops in order to address hunger and malnutrition. This has led to the re-evaluation of neglected species such as Chinese yam (Dioscorea polystachya Turcz.), which has been cultivated for centuries in East Asia as a food crop and as a widely-used ingredient in traditional Chinese medicine. The tubers are rich in nutrients, but also contain bioactive metabolites such as resistant starches, steroidal sapogenins (like diosgenin), the storage protein dioscorin, and mucilage polysaccharides. These health-promoting products can help to prevent cardiovascular disease, diabetes, and disorders of the gut microbiome. Whereas most edible yams are tropical species, Chinese yam could be cultivated widely in Europe and other temperate regions to take advantage of its nutritional and bioactive properties. However, this is a laborious process and agronomic knowledge is fragmented. The underground tubers contain most of the starch, but are vulnerable to breaking and thus difficult to harvest. Breeding to improve tuber shape is complex given the dioecious nature of the species, the mostly vegetative reproduction via bulbils, and the presence of more than 100 chromosomes. Protocols have yet to be established for in vitro cultivation and genetic transformation, which limits the scope of research. This article summarizes the sparse research landscape and evaluates the nutritional and medical applications of Chinese yam. By highlighting the potential of Chinese yam tubers, we aim to encourage the adoption of this orphan crop as a novel functional food.

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“…Flavonoids, amino acids, trace elements, vitamins and volatile oils, phthalides, organic acids, polysaccharides [13] Antiblood deficiency, hematopoietic activities, antiinflammatory activity, antifibrotic action, antispasmodic activity, antioxidant activities, and neuroprotective action, cardio-and cerebrovascular effects, antitumor [13] Dioscorea oppositifolia Dioscoreaceae A-J-037 15 Yam polysaccharides, diosgenin, adenosine, and arbutin [14][15][16][17] Estrogen-like effects, hypoglycemic effects, antioxidant and antitumor activities, immunomodulatory activity, enhancing cognitive function [14][15][16][17] Cornus officinalis Cornaceae A-G-075 15…”

Section: Discussionmentioning

confidence: 99%

Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis

Jiang

Wei

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Vascular endothelial growth factor receptor-2 (VEGFR-2) regulates the mitogen-activated protein kinase (MAPK) signaling pathway and plays an important role in angiogenesis. Bu Shen Zhu Yun decoction (BSZYD) can improve endometrial receptivity and embryo implantation rates in patients undergoing in vitro fertilization. However, whether BSZYD improves endometrial receptivity via angiogenesis remains unclear. Here, we investigated the effects of BSZYD on the proliferation, migration, and angiogenesis of human endometrial microvascular endothelial cells (HEMECs) and found that BSZYD upregulated the expression of cyclin D1, matrix metalloproteinase 9 (MMP9), and proliferating cell nuclear antigen (PCNA) in HEMECs. Cell Counting Kit 8 assay, scratch-wound assay, and Tube Formation Assay results showed that BSZYD promoted the proliferation, migration, and angiogenesis of HEMECs. Western blot analysis results revealed the activation of the MAPK signaling pathway by BSZYD through the upregulation of VEGF and VEGFR-2 expression. Together, these findings highlight the novel mechanism underlying BSZYD-mediated improvement in endometrial receptivity through the MAPK signaling pathway.

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Hypoglycemic Effect of Chinese Yam (Dioscorea opposita rhizoma) Polysaccharide in Different Structure and Molecular Weight

Abstract: Three polysaccharides from Chinese yam tuber were isolated in this study. Their structures were characterized and hypoglycemic effects were evaluated. The result clearly identified the benefits of this plant as a healthy functional food.

Cited by 64 publications

References 38 publications

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

An underutilized orphan tuber crop—Chinese yam : a review

Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis

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