Hypoglycemic Effect of Ethanolic Extract of<i>Musa sapientum</i>on Alloxan-Induced Diabetes Mellitus in Rats and Its Relation with Antioxidant Potential

Dhanabal, S P; Sureshkumar, Muthusamy; Ramanathan, Meena; Suresh, B.

doi:10.1080/j157v05n02_02

Cited by 32 publications

(4 citation statements)

References 16 publications

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“…Significant antioxidant properties have been observed in investigations of peel extracts [ 3 ], inflorescence and stalk [ 4 ] of M. sapientum . Its banana pulps [ 5 ] and unripe plantain bananas [ 6 ] have been reported to have anti-ulcerogenic properties; its seeds possess antioxidant, anti-diarrheal, and anti-microbial activities [ 7 ], its flowers possess hypoglycemic activities [ 8 ] while its sucker possesses hypoglycemic [ 9 ] and anti-ulcerogenic [ 2 ] potentials.…”

Section: Introductionmentioning

confidence: 99%

Musa sapientum with exercises attenuates hyperglycaemia and pancreatic islet cells degeneration in alloxan-diabetic rats.

Akinlolu¹,

Salau²,

Ekor³

et al. 2015

J Intercult Ethnopharmacol

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Aim:We tested the hypothesis that administrations of methanolic extracts of Musa sapientum sucker (MEMS) with exercises attenuated hyperglycemia in alloxan-diabetic rats.Materials and Methods:A total of 40 adult male rats were divided into equal eight groups. Normoglycemic Group A was Control. Alloxan (180 mg/kg, i.p.) was administered to rats in Groups B - H to induce diabetes. Group B (diabetic control) received physiological saline. Groups C - H received MEMS (5 mg/kg), MEMS (10 mg/kg), Glibenclamide (5 mg/kg), MEMS (5 mg/kg) + exercises, MEMS (10 mg/kg) + exercises and Exercises only, respectively. Changes in body weight, blood glucose levels (BGL) and pancreatic histology were evaluated during or at the end of experiment. Body weights and BGL of rats were expressed as mean ± standard deviation and analyzed using the statistical software program SPSS 15. Statistical comparisons were done using the Student’s t-test for unpaired samples. Differences between groups were determined as significant at P ≤ 0.05.Results:Significantly (P < 0.05) decreased bodyweight was observed in B and H compared to A and C - G. Treatment with MEMS significantly (P < 0.05) decreased elevated BGL in C and D. Hypoglycemic effect of MEMS appeared enhanced with exercises in F and G. Exercises regimen alone (H) resulted in percentage reduction in BGL lower than those of C - G. Histopathological examinations revealed normal pancreas (A), atrophied islet cells (B), hyperplasia with adequate population of islet cells (C - G), and reduced hyperplasia of islet cells (H).Conclusion:MEMS with exercises attenuated hyperglycemia in alloxan-diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Musa sapientum with exercises attenuates hyperglycaemia and pancreatic islet cells degeneration in alloxan-diabetic rats.

Akinlolu¹,

Salau²,

Ekor³

et al. 2015

J Intercult Ethnopharmacol

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“…Musa sapientum commonly known as ‘banana’ is widely used in Indian folk medicine for the treatment of diabetes mellitus [ 10 ]. The available literature confirms that flavonoids are present in banana flowers [ 11 ].The chloroform, water and ethanol extract of Musa sapientum flowers were found to exhibit hypoglycaemic activity in alloxan diabetic rat [ 12 ]. Intraperitoneal administration of prunin (naringenin 7-O-β-D-glucoside) produces a significant hypoglycemic effect in diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus

Ganugapati¹,

Baldwa²,

Lalani³

2012

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Diabetes mellitus is a metabolic disorder caused due to insulin deficiency. Banana flower is a rich source of flavonoids that exhibit anti diabetic activity. Insulin receptor is a tetramer that belongs to a family of receptor tyrosine kinases. It contains two alpha subunits that form the extracellular domain and two beta subunits that constitute the intracellular tyrosine kinase domain. Insulin binds to the extracellular region of the receptor and causes conformational changes that lead to the activation of the tyrosine kinase. This leads to autophosphorylation, a step that is crucial in insulin signaling pathway. Hence, compounds that augment insulin receptor tyrosine kinase activity would be useful in the treatment of diabetes mellitus. The 3D structure of IR tyrosine kinase was obtained from PDB database. The list of flavonoids found in banana flower was obtained from USDA database. The structures of the flavonoids were obtained from NCBI Pubchem. Docking analysis of the flavonoids was performed using Autodock 4.0 and Autodock Vina. The results indicate that few of the flavonoids may be potential activators of IR tyrosine kinase.

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“…Calcium 56mg, iron 56.4mg, copper 13mg, potassium 553.3mg, magnesium 48.7mg and vitamin E 1.07mg (Shilpa et al,2017). [20][21][22][23][24][25][26][27][28][29][30] The minerals content of banana flower of two cultivars Musa paradisiaca and Musa chiliocarpa.The minerals content in banana flowers were determined by using SPECTROXEPOSEDXRF spectrometer at department of physics, niversity of Mandalay. The mineral content of Musa paradisiaca, Aluminum 0.1307%, silicon 0.1120%, phosphorus 0.3569% ,sulfur 0.6860%, chlorine 0.9821%, potassium 5.138%, calcium 0.5667%, magnesium 0.0106%, iron 0.p1547%.…”

Section: Introductionmentioning

confidence: 99%

A review on banana flower: Nutritional composition, processed products and health benefits

Shekhara Naik R,

Kavya M H,

Manasa R

et al. 2023

IJNMHS

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India is the world’s largest producer of banana with 13.90 million tons followed by Uganda (10.14 million tons). Banana blossom also known as a banana heart, is a fleshy purple - skinned flower shaped like tear, which grows at the end of banana fruit cluster. Now days researchers aimed to addressing dietary related diseases through promotion of food products enriched with high protein, vitamins, minerals and dietary fiber. Banana blossom is rich source of nutrients and antioxidants which have several health benefits. The juice from the male bud provides an apparent remedy for stomach problems in people of all ages. Banana blossom is a popular dish in Sri Lanka. It is consumed as a curry as well as a boiled or deep fried salad with rice and wheat bread. It is generally valued as a fiber-rich source. Dietary fiber has demonstrated its benefits in health and disease prevention in medical nutrition therapy. Consumption of dietary fiber is known to lower blood cholesterol level, normalize blood glucose and insulin level, promote normal laxation, avoid constipation, prevent diverticulosis and diverticukitis, lower the risk of colon cancer and breast cancer and prevent obesity. The flower has been used to treat bronchitis, constipation and peptic ulcer. The extract has anti-oxidant property that prevents free radicals and control cell and tissue damage. Based on the main components of banana flower extract and its anti-oxidant properties, we hypothesized that the banana flower extract may have anticancer activities against cancer cell lines.

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Hypoglycemic Effect of Ethanolic Extract ofMusa sapientumon Alloxan-Induced Diabetes Mellitus in Rats and Its Relation with Antioxidant Potential

Cited by 32 publications

References 16 publications

Musa sapientum with exercises attenuates hyperglycaemia and pancreatic islet cells degeneration in alloxan-diabetic rats.

Musa sapientum with exercises attenuates hyperglycaemia and pancreatic islet cells degeneration in alloxan-diabetic rats.

Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus

A review on banana flower: Nutritional composition, processed products and health benefits

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