Hypoglycemic effect of <i>Opuntia ficus indica</i> in non insulin‐dependent diabetes mellitus patients

Frati, Alberto; Jiménez, Ernesto; Ariza, Carles

doi:10.1002/ptr.2650040507

Cited by 90 publications

(56 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The cladodes are utilized, in traditional medicine, for the management of ulcers, wounds, rheumatic pain and fatigue. Experimental studies showed that cactus pear could reduce glucose and cholesterol levels in human blood (Frati et al, 1990;Stintzing et al, 2001). Chemopreventive effect on oxidative stress and genotoxicity was also recently investigated (Brahmi et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Opuntia Ficus-Indica Aqueous Extract against Carbon Tetrachloride-Induced Toxicity in Rats

Djerrou¹,

Maameri²,

Halmi³

et al. 2015

OnLine Journal of Biological Sciences

View full text Add to dashboard Cite

The present study was undertaken to evaluate the hepatoprotective activity of Opuntia ficus-indicaL. aqueous extract. About 24 Wistar male rats were divided randomly to 4 groups of 6 each. The 1st was given distilled water and served as normal control (CRL). The 2nd was intoxicated orally with carbon tetrachloride at a dose of 1.5 mL/kg each 72 h (CCl4 group) for a period of 15 days. 2 other groups were intoxicated as CCl4 group and treated once daily by aqueous extract of Opuntiaficusindica L. at doses of 2 mL/kg or 5 mL/kg respectively (OFI1 and OFI2 groups). The results showed a significant elevation of Aspartate Amino Transferase (AST) (ANOVA, p<0.001) and Alanine Amino Transferase (ALT) (ANOVA, p<0.05) in CCl4 group compared to control. Treatment of rats with cactus aqueous extract at 2 mL/kg has resulted in significant reduction of AST (ANOVA, p<0.001) compared to CCl4 group. In OFI2 group, AST and ALT were increased but non significantly compared to CCl4 group. The other tested parameters (Urea, creatinine and uric acid) have not recordered significant changes between all groups. The study concluded that Opuntiaficus-indica L. aqueous extract may exert hepatoprotective effect at 2 mL/kg against CCl4-induced toxicity at least by decreasing AST enzyme activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Opuntia Ficus-Indica Aqueous Extract against Carbon Tetrachloride-Induced Toxicity in Rats

Djerrou¹,

Maameri²,

Halmi³

et al. 2015

OnLine Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…248) is an attractive crop in this application because its dark purple fruit have medicinal benefits, and this accession tolerates drought, salt, and B while accumulating and volatilizing Se (Bañ uelos and Lin, 2010). Without Se enrichment, Opuntia fruit and cladode already contain chemotherapeutic qualities that, when eaten, have been shown to help protect the human immune and nervous systems, prevent oxidative stress, help treat gastritis, hyperglycemia, arteriosclerosis, diabetes, and prostatic hypertrophy, and help prevent multiple human cancers (Frati et al, 1990;Hegwood, 1990;Palevitch et al, 1993;Dok-Go et al, 2003;Kuti, 2004;Zou et al, 2005;Feugang et al, 2006). Opuntia fruit is also considered an excellent source of mineral nutrition, being enriched in calcium, potassium, and magnesium (Feugang et al, 2006).…”

mentioning

confidence: 99%

Selenium Accumulation, Distribution, and Speciation in Spineless Prickly Pear Cactus: A Drought- and Salt-Tolerant, Selenium-Enriched Nutraceutical Fruit Crop for Biofortified Foods

Bañuelos

Fakra²,

Walse³

et al. 2010

Plant Physiol.

View full text Add to dashboard Cite

The organ-specific accumulation, spatial distribution, and chemical speciation of selenium (Se) were previously unknown for any species of cactus. We investigated Se in Opuntia ficus-indica using inductively coupled plasma mass spectrometry, microfocused x-ray fluorescence elemental and chemical mapping (mXRF), Se K-edge x-ray absorption near-edge structure (XANES) spectroscopy, and liquid chromatography-mass spectrometry (LC-MS). mXRF showed Se concentrated inside small conic, vestigial leaves (cladode tips), the cladode vasculature, and the seed embryos. Se K-edge XANES demonstrated that approximately 96% of total Se in cladode, fruit juice, fruit pulp, and seed is carbon-Se-carbon (C-Se-C). Micro and bulk XANES analysis showed that cladode tips contained both selenate and C-Se-C forms. Inductively coupled plasma mass spectrometry quantification of Se in high-performance liquid chromatography fractions followed by LC-MS structural identification showed selenocystathionine-to-selenomethionine (SeMet) ratios of 75:25, 71:29, and 32:68, respectively in cladode, fruit, and seed. Enzymatic digestions and subsequent analysis confirmed that Se was mainly present in a "free" nonproteinaceous form inside cladode and fruit, while in the seed, Se was incorporated into proteins associated with lipids. mXRF chemical mapping illuminated the specific location of Se reduction and assimilation from selenate accumulated in the cladode tips into the two LC-MS-identified C-Se-C forms before they were transported into the cladode mesophyll. We conclude that Opuntia is a secondary Se-accumulating plant whose fruit and cladode contain mostly free selenocystathionine and SeMet, while seeds contain mainly SeMet in protein. When eaten, the organic Se forms in Opuntia fruit, cladode, and seed may improve health, increase Se mineral nutrition, and help prevent multiple human cancers.

show abstract

“…cladodes are used for the treatment of gastric ulcer (Galati et al, 2001). Pre-treatment test in rats revealed a protective action against ethanol-induced ulcer (Galati et al, 2003).…”

Section: Anti-ulcer Activitymentioning

confidence: 99%

“…It has been used in traditional folk medicine because of its role in treating a number of diseases and conditions, including antiinflammatory effects (Park et al, 1998), hypoglycemic effects (Frati et al, 1990), inhibition of stomach ulceration (Galati et al, 2003), neuroprotective effects (Dok-Go et al, 2003). Through antioxidant actions and also used for treating diabetes, burns, bronchial, asthma and indigestion in many countries over the world (Kim et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological actions of Opuntia ficus indica: A Review

Kaur¹

2012

J. App. Pharm. Sci.

View full text Add to dashboard Cite

Cactus (Opuntia ficus-indica) belongs to the family Cactaceae. Family Cactaceae is reported to contain about 130 genera and nearly 1500 species. This plant is native of Mexico and it is widely distributed in Mexico and in all American hemispheres as well as in Africa and in the Mediterranean basin. It has been used in traditional folk medicine because of its role in treating a number of diseases and conditions, including anti-inflammatory effects hypoglycemic effects inhibition of stomach ulceration, neuroprotective effects Through antioxidant actions and also used for treating diabetes, burns, bronchial, asthma and indigestion in many countries over the world. It is also used in Pharma industry as a pharmaceutical agent. The fruit, as well as cactus stem are used to prepare value-added products, such as jam, squash, wine, pickle, body lotions, shampoo, creams, etc. It also has several medicinal and industrial uses. Its seeds can be used as flavouring agents. Due to the remarkable biological activity of Opuntia and its constituents, it will be appropriate to develop them as a medicine.

show abstract

Hypoglycemic effect of Opuntia ficus indica in non insulin‐dependent diabetes mellitus patients

Abstract: Opuntia ficus indica exerts hypoglycemic effects in NIDDM patients independent of its heating or blending during preparation.

Cited by 90 publications

References 3 publications

Hepatoprotective Effect of Opuntia Ficus-Indica Aqueous Extract against Carbon Tetrachloride-Induced Toxicity in Rats

Hepatoprotective Effect of Opuntia Ficus-Indica Aqueous Extract against Carbon Tetrachloride-Induced Toxicity in Rats

Selenium Accumulation, Distribution, and Speciation in Spineless Prickly Pear Cactus: A Drought- and Salt-Tolerant, Selenium-Enriched Nutraceutical Fruit Crop for Biofortified Foods

Pharmacological actions of Opuntia ficus indica: A Review

Contact Info

Product

Resources

About