Hypoglycemic effect of <i>Rhizophora mucronata</i> in streptozotocin induced diabetic rats

Pandey, Anvita; Gupta, P. P.; Lal, Vijay

doi:10.1515/jcim-2012-0057

Cited by 12 publications

(13 citation statements)

References 21 publications

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“…The similar result was reported for Rhizophora mucornata in which high dose (200mg/kg) of hydroalcoholic extract of the plant was found more potent than the low dose in first 6 h of the study. 16 For the daily treatment of SOE and glibenclamide up to 28days, it was found that the higher dose of SOE (51.21%) was more significant than SOE low dose (38.98%) in blood glucose lowering while compared to glibenclamide (55.97%). The similar study of the hypoglycemic effect of Kyllinga triceps plant extracts at 200mg/kg on STZ induced rats was reported as a significant (47.2% blood glucose reduction) than low dose.…”

Section: Discussionmentioning

confidence: 96%

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Antidiabetic Potential and HPTLC Fingerprinting of Schleichera oleosa (Lour) Oken

Goswami¹,

Singh²

2019

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Introduction: Schleichera oleosa (Lour) Oken., also known as Lac tree, is a traditional plant used to treat different ailments since ancient time. The folkloric use of this plant as hypoglycemics is still un-revealed scientifically. So, the present study includes the in-vivo evaluation of hypoglycemic activity with HPTLC fingerprinting, qualitative and quantitative phytochemical screening of the extracts of the plant. Methods: Ethanolic extract of the plant (SOE) was subjected for phytochemical screening and HPTLC finger printing (using CAMAG LINOMAT 5 instrument). For the evaluation of hypoglycemic activity Streptozotocin (STZ) induced diabetic rats were treated with glibenclamide (0.5mg/kg body weight) and ethanolic extract (100 mg/kg and 200 mg/kg body weight) of the plant. Acute and chronic studies were performed for the evaluation of blood glucose levels. Results: The presence of alkaloids, tannins, phenolics and flavonoids were confirmed in the preliminary phytochemical screening. Quantitative screening of total tannins (6.15±4.20), total flavonoids (25.13±3.21) and total phenolic compounds (48.09±2.58) were reported. HPTLC fingerprinting analysis of SOE affirmed the presence of quercetin. Conclusion: The positive outcome was observed in the results of hypoglycemic activity, as all the treatments significantly decreased blood glucose level. During the study, SOE and glibenclamide maintained the body weight of the rats while diabetic control reduced the body weight by 11.33%. In support of its traditional use Schleichera oleosa (Lour) Oken. was proved to be a potent antidiabetic herbal plant.

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Section: Discussionmentioning

confidence: 96%

“…The blood samples were collected from all the rats through tail-vein and blood glucose levels were measured (in mg/dL) instantly by using glucometer (Accu-chek, Roche Diagnostic, Mannheim, Germany). 16…”

Section: Blood Glucose Estimationmentioning

confidence: 99%

Antidiabetic Potential and HPTLC Fingerprinting of Schleichera oleosa (Lour) Oken

Goswami¹,

Singh²

2019

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“…19 Some recent studies also supported that hydro-alcoholic extract of R. mucronata leaves exhibited antiradical and anti-diabetic effects. 12,13 A study from Bangladesh demonstrated that, the ethanol extracts of Rhizophora mucronata Poir leaves showed significant inhibition of carbohydrate digestion and absorption, which has resulted in hypoglycemic effects of Rhizophora mucronata.…”

Section: Discussionmentioning

confidence: 99%

“…5 In South Asian countries together with India, the leaves of R. mucronata are being used traditionally for the remedy of diabetes. 6,7 It is abundantly found on the coastal region. R. mucronata L. leaves showed the presence of a good amount of polyphenols, like flavonoid, tannin, glycoside, phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

“…11 Recent study reported the anti-diabetic action of hydro-methanolic and hydro-ethanolic extract of R mucronata (Sundarban Mangrove) leaves in diabetes model. 12,13 Hence, the present study has undertaken to explore the comparative analysis between fresh juice and ethanolic extract of the leaves of Rhizophora mucronata Lam. in diabetic rat model.…”

Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of anti-diabetic activity of fresh juice and ethanolic extract of Sunderban mangrove Rhizophora mucronata Lam. leaves in animal model

Adhikari

Ray

Sur

et al. 2017

Int J Basic Clin Pharmacol

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Background: Mangrove flora possess compounds with potential medicinal values with unique bioactive components. Traditionally Rhizophora mucronata, a mangrove has been used extensively for the treatment of diabetes. Studies revealed that, the leaves of Rhizophora (Bhora) had promising anti-diabetic action in rat model.Methods: A comparative analysis of the anti-diabetic action of fresh juice and ethanolic extract of Rhizophora mucronata leaves was carried out in Streptozotocin induced diabetic model and the different biochemical parameters were evaluated.Results: Present research explored a comparative analysis of the anti-diabetic action of fresh juice and ethanolic extract of leaves of Rhizophora mucronata Lam. in Streptozotocin induced diabetic model. The ethanolic extract showed more potent effect in lowering the elevated blood sugar in the diabetic rats, 200mg/kg was the most effective dose for both the extracts. The ethanol extract was more beneficial having potent lipid lowering action along with anti-hyperglycemic property.Conclusions: This supports the scientific validation for using Rhizophora mucronata leaves in the treatment of diabetes as traditional folk medicine. Identification of the bioactive molecule is under process.

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Neuroprotective effects of mangrove plants

Ravikiran

Anand²,

Ramachandregowda³

et al. 2020

Biotechnological Utilization of Mangrove Resources

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Hypoglycemic effect of Rhizophora mucronata in streptozotocin induced diabetic rats

Cited by 12 publications

References 21 publications

Antidiabetic Potential and HPTLC Fingerprinting of Schleichera oleosa (Lour) Oken

Antidiabetic Potential and HPTLC Fingerprinting of Schleichera oleosa (Lour) Oken

Comparative evaluation of anti-diabetic activity of fresh juice and ethanolic extract of Sunderban mangrove Rhizophora mucronata Lam. leaves in animal model

Neuroprotective effects of mangrove plants

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