Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism

Mao, Xianqing; Feng, Yu; Wang, Nian; Wu, Yong; Zhang, Feng; Wu, Ke; Liu, Min; Ouyang, Jingping

doi:10.1016/j.phymed.2008.12.011

Cited by 87 publications

(46 citation statements)

References 26 publications

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“…Several investigations have demonstrated that plant polysaccharides have hypoglycemic activity [16][17][18]. M. charantia (Bitter melon) of family (Cucurbitaceae) is a herb grown in South Asia and is well-known as an anti-inflammatory, anti-tumor, antiviral, hypo-lipidemic and as anti-diabetic agent [19,20].…”

Section: Introductionmentioning

confidence: 99%

Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats

Raish

Ahmad

Jan

et al. 2016

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats

Raish

Ahmad

Jan

et al. 2016

International Journal of Biological Macromolecules

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“…Therefore, APS have received a great deal of attention [21] and have been applied in the treatment of many diseases, including tumor and infectious diseases, in Chinese medicine [22]. APS therapy ameliorated vacuolar degeneration of mitochondria and fragmentation of mitochondrial cristae of hepatocytes in insulin-resistance mice, which indicates the mitochondrial dysfunction coupled with the increased metabolic stress and the protective effect of APS [19]. …”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism

Zhang²,

Kuang

et al. 2012

IJMS

109

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The current study was performed to investigate mitochondrial protection and anti-aging activity of Astragalus polysaccharides (APS) and the potential underlying mechanism. Lipid peroxidation of liver and brain mitochondria was induced by Fe2+–Vit C in vitro. Thiobarbituric acid (TBA) colorimetry was used to measure the content of thiobarbituric acid reactive substances (TBARS). Mouse liver mitochondrial permeability transition (PT) was induced by calcium overload in vitro and spectrophotometry was used to measure it. The scavenging activities of APS on superoxide anion (O2•−) and hydroxyl radical (•OH), which were produced by reduced nicotinamide adenine dinucleotide (NADH)—N-Methylphenazonium methyl sulfate (PMS) and hydrogen peroxide (H2O2)–Fe2+ system respectively, were measured by 4-nitrobluetetrazolium chloride (NBT) reduction and Fenton reaction colorimetry respectively. The Na2S2O3 titration method was used to measure the scavenging activities of APS on H2O2. APS could inhibit TBARS production, protect mitochondria from PT, and scavenge O2•−, •OH and H2O2 significantly in a concentration-dependent manner respectively. The back of the neck of mice was injected subcutaneously with D-galactose to induce aging at a dose of 100 mg/kg/d for seven weeks. Moreover, the activities of catalase (CAT), surperoxide dismutase (SOD) and glutathione peroxidase (GPx) and anti-hydroxyl radical which were assayed by using commercial monitoring kits were increased significantly in vivo by APS. According to this research, APS protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting mitochondrial PT and increasing the activities of antioxidases. Therefore, APS has the effect of promoting health.

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“…Recently it was found that in rats with type 2 diabetes, APS exhibited insulinsensitizing and hypoglycemic activities (Mott et al, 2000;Mao et al, 2009). However, little is known about the protective effect of APS on the down-regulation of ABCA1 by TNF-α.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP‐1 derived foam cells exposed to tumor necrosis factor‐alpha

Wang

Yang

Cheng

et al. 2009

Phytotherapy Research

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Astragalus polysaccharide (APS), the main extract from the traditional Chinese medicinal herb Astragalus membranaceus, has been reported to benefit the treatment of immune-inflammatory diseases and metabolic disorders. In atherosclerotic plaques, proinflammatory cytokines exert adverse effects on lipids thereby aggravating atherosclerosis. Recent evidence shows that tumor necrosis factor-alpha (TNF-alpha) can down-regulate the expression of ATP-binding cassette transporter A1 (ABCA1), which plays a vital role in reverse cholesterol transport and determines the process of atherosclerosis. In the present study, the effects of APS on ABCA1 expression, cholesterol effluent rate and total cholesterol content of THP-1 derived foam cells exposed to TNF-alpha were investigated. Compared with the foam cells exposed to TNF-alpha, ABCA1 expression was promoted in the presence of APS. Consequently the cholesterol effluent rate increased and the total cholesterol content decreased significantly. TNF-alpha could enhance the activity of nuclear factor-kappa B (NF-kappaB) in the foam cells. This effect could be attenuated by APS. These findings suggest that APS could protect ABCA1 against the lesion of TNF-alpha in THP-1 derived foam cells, which may contribute to its antiatherosclerotic properties.

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Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism

Cited by 87 publications

References 26 publications

Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats

Momordica charantia polysaccharides mitigate the progression of STZ induced diabetic nephropathy in rats

Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism

Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP‐1 derived foam cells exposed to tumor necrosis factor‐alpha

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