Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring

Long, Hong‐Ping; Liu, Jian; Xu, Ping; Xu, Kang‐Ping; Li, Jing; Tan, Gui‐Shan

doi:10.1016/j.phytochem.2021.113073

Cited by 14 publications

(6 citation statements)

References 26 publications

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“…Therefore, advocating a healthy lifestyle and searching for effective glucose-lowering drugs to reduce the risk of diabetes are critical. Currently, based on ancient herbal formulas and modern pharmacological validation, multiple natural products, including polyphenols, flavonoids, and alkaloids, have been applied to ameliorate hyperglycemia. − Flavonoids are the major active components isolated from M. nigra L. In this research, the plasma glucose, plasma insulin, HOMA-IR index, and lipoprotein profile data suggested that TFM treatment is effective in reducing the levels of blood lipids and plasma glucose and thus markedly ameliorates insulin resistance in prediabetes mice.…”

Section: Discussionmentioning

confidence: 79%

Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

Ren

Sun

Guo

et al. 2022

J. Agric. Food Chem.

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Prediabetes is a critical stage characterized by insulin resistance. Morus nigra L., an edible plant, is widely used in food and nutritive supplements and exhibits various pharmacological activities; however, its therapeutic effects and mechanisms on prediabetes have rarely been reported. In this research, the major components of total flavonoids of M. nigra L. (TFM) were identified, and TFM treatment was found to reduce prediabetes progressing to type 2 diabetes mellitus (T2DM) from 93.75 to 18.75%. The microbiota and next-generation sequencing combined with western blotting in vivo and in vitro demonstrated that TFM and its components ameliorated insulin resistance mediated by the suppressor of cytokine signaling and protein tyrosine phosphatase 1B, which benefited by maintaining intestinal homeostasis and restraining plasma levels of inflammatory factors. This study confirmed the T2DM prevention effect of TFM and revealed the underlying mechanism, setting the stage for the design of functional foods for diabetes prevention.

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Section: Discussionmentioning

confidence: 79%

Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

Ren

Sun

Guo

et al. 2022

J. Agric. Food Chem.

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“…The glucose consumption (GC) of HepG2 cells was evaluated according to a previous report . The HepG2 cells were seeded in 96-well plates with 5 × 10 3 cells per well.…”

Section: Methodsmentioning

confidence: 99%

Glucose-Triggered Release of trans-N-p-Coumaroyltyramine from Zeolitic Imidazolate Framework-8 (ZIF8) Modified with Dioscorea opposita Thunb Polysaccharide

et al. 2023

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A Dioscorea opposita Thunb polysaccharide (DOP)modified ZIF8 material was developed in this study, which can be used as a "smart" glucose-responsive carrier to control the slow release of drugs. The 3-aminophenylboronic acid (APBA) functionalized carboxylated long-chain polymer poly(ethylene glycol) (PEG) segments, which were first modified on the surface of ZIF8 nanoparticles with a hydrogen bond and then chemically cross-linked with DOP through a borate ester bond, leading to the drugs loaded on ZIF8 being "closed" in PBS but being "open" via taking off the DOP coating in high concentrations of glucose; thus, leakage can be prevented in the drug loaded and a glucose-triggered release can effectively result. Moreover, the materials showed good biocompatibility and the released trans-N-p-coumaroyltyramine (NCT) could work synergistically with the DOP to improve insulin resistance and promote glucose consumption in insulinresistant HepG2 cells.

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“…One of them, siamamenflavone B (18), exhibited potent inhibition of wild-type EGFR protein [45]. Selaginella tamariscina yielded three novel biflavonoids: involvenflavone G (20), H (21), and I ( 22); H and I may have potent hypoglycemic effects [46].…”

Section: Structural Characteristics Of Selaginella Biflavonoidmentioning

confidence: 99%

“…It has been shown that ginkgetin inhibited human leukemia cell proliferation through the extrinsic pathway by TNF-α signaling [106]. Amentoflavone induces apoptosis in SiHa and CaSki cervical cancer cells by inhibiting the expression of human papillomavirus protein E7, which is achieved through an intrinsic pathway [46]. It has also been demonstrated that ginkgetin activated both exogenous and endogenous pathways in MCF-7 cells, including upregulating the expression of Bax while downregulating the expression of Bcl-2 and survivin and increasing the active production of caspase-8, caspase-9, and caspase-3 in MCF-7 cells [107].…”

Section: Induction Of Cancer Cell Apoptosismentioning

confidence: 99%

Advances in the Anti-Tumor Activity of Biflavonoids in Selaginella

Ren

Gao

et al. 2023

IJMS

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Despite the many strategies employed to slow the spread of cancer, the development of new anti-tumor drugs and the minimization of side effects have been major research hotspots in the anti-tumor field. Natural drugs are a huge treasure trove of drug development, and they have been widely used in the clinic as anti-tumor drugs. Selaginella species in the family Selaginellaceae are widely distributed worldwide, and they have been well-documented in clinical practice for the prevention and treatment of cancer. Biflavonoids are the main active ingredients in Selaginella, and they have good biological and anti-tumor activities, which warrant extensive research. The promise of biflavonoids from Selaginella (SFB) in the field of cancer therapy is being realized thanks to new research that offers insights into the multi-targeting therapeutic mechanisms and key signaling pathways. The pharmacological effects of SFB against various cancers in vitro and in vivo are reviewed in this review. In addition, the types and characteristics of biflavonoid structures are described in detail; we also provide a brief summary of the efforts to develop drug delivery systems or combinations to enhance the bioavailability of SFB monomers. In conclusion, SFB species have great potential to be developed as adjuvant or even primary therapeutic agents for cancer, with promising applications.

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Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring

Cited by 14 publications

References 26 publications

Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization

Glucose-Triggered Release of trans-N-p-Coumaroyltyramine from Zeolitic Imidazolate Framework-8 (ZIF8) Modified with Dioscorea opposita Thunb Polysaccharide

Advances in the Anti-Tumor Activity of Biflavonoids in Selaginella

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