Hypoglycemic, Hematologic and Hypolipidemic Activity of Mucuna Pruriens Ethanol Leaf Extract in Alloxan Induced Diabetic Rats

Akomas, SC; Okafor, Anthony I.; Ijioma, Solomon Nnah

doi:10.9734/arrb/2014/11735

Cited by 8 publications

(13 citation statements)

References 8 publications

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“…It has been reported that mortality is the expected end point of acute toxicity and non observation of mortality within a population treated with a dose range at which mortality is expected indicates tolerance or lack of acute toxicity [19]. Similar conclusions were drawn in other acute toxicity investigations involving plant materials [20].…”

Section: Discussionsupporting

confidence: 70%

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Relative Organ Weights and Histological Changes in Wistar Rats Treated with a South East Nigerian Polyherbal Formulation (Ajumbise)

Ijioma¹,

Osim²,

Nwankwo³

et al. 2018

IJBCRR

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Background and Aim: Ajumbise is a polyherbal formulation used in Southeast Nigeria for enhancing labour, facilitating the expulsion of retained placenta, relieving menstrual and postdelivery pains and promoting involution of the uterus. In this study, the effect of the Polyherbal formulation on body weights, relative organ weights and liver and kidney histology was evaluated. Methods: Forty rats were divided into four groups of ten rats each and were assigned daily oral administration of the extract for 28 days. While group 1 served as the control, groups 2, 3 and 4 were administered increasing doses of the extract. At the end of treatment organs were collected for Original Research Article histological analysis respectively. Students's t-test at 95% level of significance was used for statistical analysis. Results: Acute toxicity study result indicated zero mortality in all groups within the 24 hours of thestudy, even at a dose of 6000 mg/kg body weight. Body weight gain was significantly lowered in all treatment groups when compared with the control group (P<0.05). Relative liver weight did not significantly differ from that of the control except for the 800 mg/kg treated group where significant elevation was observed (P< 0.05). Relative kidney weights was significantly elevated in groups treated with 200 and 400 mg/kg (P<0.05). No significant histological changes were observed between treatment groups and control except for 800 mg/kg treated group where some inflammatory cells were observed masking the features of the portal triad. The arrangement of the hepatocytes, architecture of the portal triad comprising of the bile duct, hepatic portal vein and hepatic artery and central vein were essentially normal and had neither congestions nor necrosis. Histological presentations of the kidneys in all groups were normal and did not significantly differ from control. Conclusion:We therefore conclude that Ajumbise polyherbal may be safe at low to moderate doses and at such doses does not pose any threat to the liver and kidney cells.

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Section: Discussionsupporting

confidence: 70%

“…The mice were thereafter monitored for toxicity signs and deaths within 24 hours. The number of deaths recorded in each group by the end of 24 hours was used to estimate the LD 50 value for the extract according to Karber's method, as was used by Akomas et al [20] in accordance with OECD guideline 423.…”

Section: Acute Toxicity Test (Ld 50 )mentioning

confidence: 99%

Relative Organ Weights and Histological Changes in Wistar Rats Treated with a South East Nigerian Polyherbal Formulation (Ajumbise)

Ijioma¹,

Osim²,

Nwankwo³

et al. 2018

IJBCRR

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“…The anti-anaemic activity as demonstrated by Mucuna pruriens may be due to the presence of blood forming moieties in the leaf extract. Proximate analysis of the leaves showed the presence of iron, vitamin C and pro-vitamin A (Akomas et al, 2014;Madukwe et al, 2014). Iron is an essential haematopoietic factor required in the formation of the haem component of haemoglobin found in red cells.…”

Section: Kasang Et Al Fjsmentioning

confidence: 99%

Anti-Anaemic Potential of Methanolic Leaf Extract of Mucuna Pruriens on Phenylhydrazine (Phz) Induced Anaemic Albino Wistar Rats

Naman¹,

Oseni²,

Enoh³

2020

FJS

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The antianaemic potential of methanolic leaf extracts of Mucuna pruriens was investigated using phenylhydrazine (PHZ) induced anaemic albino Wistar rats. Fifteen rats used for the study were randomized into five experimental groups. To induced anaemia, the rats (except the normal control, Group E), received 60 mg/kg of the haemolytic agent Phenylhydrazine intraperitoneally (i.p) for two consecutive days. Anaemic Wistar rats in groups A and B received a daily oral dose of 500 and 250 mg/kg of the methanolic leaf extract of Mucuna pruriens. Nweze et al. (2016) had reported a median lethal dose greater than 5000 mg/kg for the methanol leaf extract of Mucuna pruriens. Groups C and D received Vitamin B12 (10 mg/kg) and normal saline (1 ml/kg), respectively. Normal control rats also received normal saline (1 ml/kg). Extract or normal saline was administered per os (p.o) while vitamin B12 was administered i.p. for a duration of 21 days. Packed cell volume (PCV) and haemoglobin concentration were determined weekly for three weeks. The result of the study indicated that both the methanolic leaf extract of Mucuna pruriens and Vitamin B12 significantly (p < 0.05) increased the packed cell volume and haemoglobin concentrations in treated rats compared to the negative control group of rats. This indicated that the methanolic leaf extract of Mucuna pruriens has anti-anaemic properties and could be utilized in the management of anaemia

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“…administration of Alloxan monohydrate (160 mg/kg) to the experimental rats successfully made the animals diabetic by the end of 48hr of the administration and was evidenced by a marked increase in the blood glucose levels of the test rats (i.e hyperglycemia). It is indeed established that the onset of diabetes mellitus is usually accompanied by hyperglycaemia [12,13]. The induction of diabetes mellitus by alloxan monohydrate is made possible due to the selective destructive effects of the agent on the beta cells of the pancreatic islets of Langerhans.…”

Section: Intraperitonealmentioning

confidence: 99%

“…The diabetic untreated rats had significantly higher total cholesterol, triglycerides, LDL-C and VLDL-C values with fall in HDL-C values when compared with the normal control which received no induction agent. Elevated total cholesterol, triglycerides, LDL-C and VLDL-C with fall in HDL are established biochemical markers which accompany the onset of diabetes mellitus and have been reported to be due to increased mobilization of free fatty acids from the peripheral fat depots into blood vessels and predisposes patients to cardiovascular problems [13,14,18]. This may be due to low insulin level as seen in diabetic uncontrolled animals furthermore, Kusunoki et al [19] reported that (streptozotocin) STZ-induced diabetic rats had low plasma insulin levels and since insulin is low there is the tendency of having low Lipoprotein lipase; this brings about high plasma levels of TG, FFA and low levels of HDL.…”

Section: Groups Of Animals Ureal Mmol/lmentioning

confidence: 99%

Yam and Moringa oliefera Seed Blend in Lipid Profile Disorders, Kidney and Liver Toxicities, in Alloxan Induced Diabetic Rats

Kanu

Alakali

Eke

et al. 2018

AFSJ

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Background and Aim: Diabetes mellitus is a chronic and very prevalent metabolic disease condition characterized by the abnormally high blood sugar level that eventually gives rise to diabetic complications affecting human and animals. Insulin deficiency increases free fatty acid influx and triglyceride levels into the blood, with reciprocal decrease in high-density lipoprotein (HDL) level. Numerous plants have in the past been screened for antidiabetic effects. Plants with

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Hypoglycemic, Hematologic and Hypolipidemic Activity of Mucuna Pruriens Ethanol Leaf Extract in Alloxan Induced Diabetic Rats

Cited by 8 publications

References 8 publications

Relative Organ Weights and Histological Changes in Wistar Rats Treated with a South East Nigerian Polyherbal Formulation (Ajumbise)

Relative Organ Weights and Histological Changes in Wistar Rats Treated with a South East Nigerian Polyherbal Formulation (Ajumbise)

Anti-Anaemic Potential of Methanolic Leaf Extract of Mucuna Pruriens on Phenylhydrazine (Phz) Induced Anaemic Albino Wistar Rats

Yam and Moringa oliefera Seed Blend in Lipid Profile Disorders, Kidney and Liver Toxicities, in Alloxan Induced Diabetic Rats

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