Hypoglycemic, hypolipidemic and antioxidant effects of green sprouts juice and functional dairy micronutrients against streptozotocin-induced oxidative stress and diabetes in rats

Abstract

Hyperglycemia, the mark normal for diabetes and associated disorders are the main goals of natural diabetes therapies. In this context, the present research was designed to study the effects of fenugreek sprouts juice (FS), barley sprouts juice (BS), cell-free probiotic extract (cell-free PE), whey protein hydrolysate (WPH) and their mixture on diabetic rats. Free radical scavenging activity, total phenolic contents (TPC) and total flavonoid contents (TFC) of each item mentioned were determined. Diabetes was induced through the injection of male rats with a single intraperitoneal dose (45 mg/kg) of streptozotocin. After the development of diabetes, diabetic rats were orally administered daily with 1ml of with fenugreek sprouts juice, barley sprouts juice, cell-free probiotic extract, whey protein hydrolysate or their mixture until the end of the study period (45 day). Oral administration of fenugreek sprouts juice, barley sprouts juice, cell-free probiotic extract, whey protein hydrolysate and their mixture to diabetic rats significantly reduced fasting blood glucose levels and improved the lipid profile. All the studied items limit the reductions of haemoglobin concentrations and plasma α-amylase activities. Also all the studied items suppressed the elevation of malondialdehyde values and the reduction of catalase activities. Histopathological investigation of pancreas, liver and kidneys of the diabetic rats showed histological alterations. On the other hand, supplementations with the tested materials lead to relieving these injuries. Results revealed that fenugreek sprouts juice, barley sprouts juice, cell-free probiotic extract, whey protein hydrolysate and their mixture had promising effects towards hyperglycemia and associated disorders.

Self-nanoemulsifying Delivery of Andrographolide: Ameliorating Islet Beta Cells and Inhibiting Adipocyte Differentiation

“…Free radicals make a significant contribution to the development of DM as such, which causes damage to beta cells. 33 , 34 Treatment with AND may protect the cells from free radicals caused by STZ. Zhang reported that AND increases insulin and prevents the loss of beta cells and their dysfunction in soleus muscles.…”

Preparation of High Nutritional Quality Soup for the Elderly

“…The elevated antioxidant activity of F5 and F9 may be due to the increase of banana and onion peels as well as lettuce and whey protein in the formulation especially that these ingredients have potent antioxidant activities as confirmed by Park et al (2018) and Mohamed et al (2019). Values are mean of three replicates ± SD, number in the same column followed by the same letter is not significantly different at 0.05 level; ND: Not detected Color is one of the most important quality features of vegetable and fruit products, where it is the first thing consumers see (Sudha et al, 2015).…”

Effect of a dietary supplement composed of hydrolyzed milk proteins and vanillin on the reduction of infection and oxidative stress induced by chemotherapy

“…(Cao & Xiong, 2017). Oral administration of a mixture of different sprouts juices, probiotics, and WPH significantly reduced oxidative stress in rats (Mohamed et al., 2019).…”