Hypoglycemic Properties of Viscum album (Mistletoe) in Alloxan-induced Diabetic Animals

Ohiri, F. C.; Esimone, CO; Nwafor, S. V.; Okoli, C. O.; Ndu, Okechukwu

doi:10.1076/phbi.41.3.184.15098

Cited by 17 publications

(17 citation statements)

References 6 publications

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“…They also lowered blood glucose in alloxan diabetic rats following single oral treatment. These findings are consistent with earlier reports on the antihyperglycemic or antidiabetic effects of these plants (Ramakrishnan et al, 1982;Khanna et al, 2002;Ohiri et al, 2003;Orhon et al, 2005;Nwaegerue et al, 2007;Zeggwah et al, 2007;Eno et al, 2008). The ability of the extracts to reduce fasting blood glucose in normal rats suggests they may possess inherent hypoglycemic effect.…”

Section: Discussionsupporting

confidence: 83%

“…V. album is also effective in the management of chronic metabolic disorders such as diabetes (Obatomi et al, 1994) and has been shown to relieve diabetic symptoms of severely hyperglycaemic streptozotocin-diabetic mice, including polydipsia, hyperphagia and body weight loss (Swanston-Flatt et al, 1989). A number of biological effects, such as anticancer, antimycobacterial, antiviral, apoptosis-inducing and immunomodulatory activities have been reported for mistletoes (Onay-Ucar et al, 2006) as well as hypoglycemic, glucose lowering or antihyperglycemic (Ohiri et al, 2003;Orhan et al, 2005;Nwaegerue et al, 2007;Eno et al, 2008) effects. Extract of the plant has also been shown to contain insulin-releasing constituents (Gray and Flatt, 1999) and possess insulinotropic and mild glucagonostatic (Eno et al, 2008) properties.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic property of some Nigerian medicinal plants

Tchimene¹,

Okoli²,

Iwu³

2016

J. Med. Plants Res.

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The antidiabetic properties of extracts of three Nigerian medicinal plants -The results showed that acute oral administration of the extracts to normoglycemic rats caused a mild to moderate non-dose-related reduction in blood glucose levels. The extracts significantly (P < 0.05) suppressed the acute postprandial rise in blood glucose to varying extents. Extract of O. basilicum lowered the elevated glucose level to 13.67% at 180 min while P. niruri and V. album reduced the glucose level to 16.87 and 17.33%, respectively. In alloxan diabetic rats, the extracts caused a significant (P < 0.05) non-dose-related reduction in blood glucose with 52.31 (O. basilicum), 44.29 (P. niruri) and 16.71% (V. album) maximum reduction at 6 h.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Antidiabetic property of some Nigerian medicinal plants

Tchimene¹,

Okoli²,

Iwu³

2016

J. Med. Plants Res.

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“…This result is consistent with that reported by Ohiri (2003) which suggested that the extract had a high safety margin and may not contain any cardio-or neuro-toxic agents. This probably explains why there is a widespread use of this extract for treatment of diseases and for preventive purposes without adverse effects reported.…”

Section: Discussionsupporting

confidence: 83%

Increased plasma total cholesterol and high density lipoprotein levels produced by the crude extract from the leaves of <i>Viscum album</i> (mistletoe).

Ben¹,

Eno²,

Ofem³

et al. 2010

Nig. J. Phys Sci

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Summary:The effect of an aqueous extract prepared from the leaves of Viscum album (Mistletoe) on plasma cholesterol and albumin levels in male Wistar rats was studied. Lethality studies revealed that the extract had an LD 50 value of 417.0mg/kg mice, intraperitoneally. The rats were randomly divided into seven (7) groups of 5 rats per group with one animal per metabolic cage. Group one served as the control (C1), groups two to six were treated with extract (200mg/kg body weight orally and daily) for a maximum of ten (10) weeks, whereas, group seven (C2) received no extract treatment but was fed on normal rat chow. All the rats had free access to rat food and drinking water. The first group (C1) was sacrificed a fortnight after the commencement of the experiment, while group seven (C2) was sacrificed at the end (10 th week) of the experiment. The extract-treated groups were sacrificed respectively in the order 2,4,6,8 and 10 week of extract administration. Whole blood was collected from these groups for analysis. Results showed significant increases (P<0.01) in the level of total cholesterol (TC) from 1.92 + 0.11mmol/L to 2.59 + 0.02mmol/L (about 35% increase) and high density lipoproteins (HDL) from 0.95 + 0.02mmol/L to 1.50 + 0.08mmol/L (about 58.50% increase) at week 10. The LDL levels, the total protein and albumin levels did not show any significant change from the control values. From the results, it is suggested that the crude aqueous extract from mistletoe leaf may be relatively safe for therapeutic use as it neither predisposes to cardiovascular risk nor adversely affects protein metabolism following prolonged period of administration.

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“…Within the treatment period (14 days), the various combined extracts effects demonstrated significant antidiabetic activities thereby reducing the BGL of the alloxan-induced diabetic rats to normal. The results of this study corroborate those of Gray and Flatt, (1999), Ohiri et al (2003) and Nwaegerue et al (2007), who had earlier reported on the antidiabetic activity of this plant. The differences in their antidiabetic activities could have been due to host-related factors which are reflected on their phytochemical profiles.…”

Section: Discussionsupporting

confidence: 82%

“…They have antioxidant activity which allows them to act as reducing agents, metal chelators and free radical quenchers (Oboh and Rocha, 2007). Studies have reported on the phytochemistry (Boci, 1993;Haas et al, 2003;Oguntoye et al, 2008), antidiabetic (Gray and Flatt, 1999;Ohiri et al, 2003;Nwaegurue et al, 2007), anti-inflammatory, cardiovascular and antimicrobial effects (Alison et al, 2000;Undie and Akubue, 1986;Oguntoye et al, 2008), cytotoxic and immunomodulatory antitumoral effects (Harmsma et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and comparative antidiabetic studies of leaf extracts of <em>Viscum</em> album from different plant hosts

Umoh¹,

Ekpo²,

Bala³

et al. 2012

Int. J. Bio. Chem. Sci

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Phytochemical screening and evaluation of antidiabetic activity of leaf extracts of Viscum album from four different plant hosts were carried out using standard procedures. The results of the phytochemical screening revealed that the different leaf extracts vary in their phytochemical constituents depending on the plant host. Moreso, all the leaf extracts of Viscum album demonstrated significant (p<0.001) lowering of blood glucose level (BGL) in alloxan-induced diabetic rats. The leaf extract of V. album from Dennettia tripetala exhibited the highest antidiabetic activity than the other extracts followed by Citrus sinensis and Pisium guajava and their activities were more pronounced than that of standard drug, glibenclamide during acute study. On prolonged treatment, Viscum album leaf extracts from C. sinensis (VAC ) and P. guajava (VAP) had comparably higher antidiabetic effects than the other extracts and glibenclamide. These were followed by that from Dacroydes edulis (VAD) while Dennettia tripetala (VADT) had the lowest antidiabetic effect. Although V. album possesses antidiabetic property, its antidiabetic efficacy depends on its phytochemical constituents which in turn depends on the plant host.

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Hypoglycemic Properties of Viscum album (Mistletoe) in Alloxan-induced Diabetic Animals

Cited by 17 publications

References 6 publications

Antidiabetic property of some Nigerian medicinal plants

Antidiabetic property of some Nigerian medicinal plants

Increased plasma total cholesterol and high density lipoprotein levels produced by the crude extract from the leaves of <i>Viscum album</i> (mistletoe).

Phytochemical and comparative antidiabetic studies of leaf extracts of <em>Viscum</em> album from different plant hosts

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