Hypogonadism and associated risk factors in male patients with type 2 diabetes mellitus attending the diabetic clinic of Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia

Teka, Sisay; Kinde, Samuel; Dedefo, Gobena; Mudi, Kissi; Tarekegn, Getahun

doi:10.1080/16089677.2018.1541668

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Dissecting the social component, most of the men with T2DM in this study were married, and they accounted for 98.9%. This finding was comparable with the proportion of married type 2 diabetic men in a similar study in Ethiopia [39]. With this finding and considering the high frequency of hypogonadism in this study, it is hypothesized that large numbers of men with T2DM might be at risk of strain marital relationships which could probably culminate in separation and divorce, hence, impacting negatively on diabetes care and creating a vicious cycle.…”

Section: Discussionsupporting

confidence: 87%

Hypergonadotropic hypogonadism in Nigerian men with type 2 diabetes mellitus

Musa

El-Bashir

Sani-Bello

et al. 2021

Clinical Diabetology

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Background. Studies have reported a higher prevalence of hypogonadism in men with type 2 diabetes mellitus (T2DM) than non-diabetic men. The pattern of hypogonadism in men with T2DM using gonadotropin-releasing hormone (GnRH) stimulation test in Sub-Saharan Africa is unknown. Objective. This study was conducted to determine the prevalence and pattern of hypogonadism in Nigerian men with T2DM. Methods. A cross-sectional study involving 358 men with T2DM and 179 non-diabetic men as controls. Androgen Deficiency in the Ageing Male (ADAM) questionnaire was administered. luteinizing hormone (LH) and follicle-stimulating hormone (FSH) both at 0 hours and 4 hours after subcutaneous buserelin injection, fasting total testosterone (TT), fasting plasma glucose and glycated haemoglobin were measured. Ninety-nine men with T2DM selected by randomization using a computer underwent GnRH stimulation test, with subcutaneous injection of 100 micrograms of buserelin. Results. The mean TT of T2DM men was significantly lower compared to the controls (8.79 ± 3.35 nmol/l vs 15.41 ± 3.79 nmol/L, p < 0.001). The prevalence of hypogonadism in T2DM men was 80.4%, comprising 38.5% of severe hypogonadism and 41.9% mild hypogonadism. The mean LH and FSH levels were significantly higher in T2DM men than the controls (9.62 ± 6.82 IU/l vs 8.24 ± 5.91 IU/l, p = 0.022 and 8.50 ± 8.17 IU/l vs 5.17 ± 3.89 IU/L, p < 0.001 respectively). There was a statistically significant exaggerated response in mean (±SD) LH and FSH levels at 4 hours after buserelin injection compared to the 0-hour levels (58.58 ± 40.72 IU/l vs 8.38 ± 6.10 IU/L, p < 0.001 and 23.03 ± 18.02 IU/l vs 8.41 ± 7.45 IU/L, p < 0.001 respectively) in men with T2DM who had GnRH stimulation tests. Conclusion. This study shows that the prevalence of hypogonadism in men with T2DM is significantly higher than in non-diabetic men with mild hypogonadism accounting for most cases. Hypergonadotropic hypogonadism occurs more frequently in men with T2DM

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Section: Discussionsupporting

confidence: 87%

Hypergonadotropic hypogonadism in Nigerian men with type 2 diabetes mellitus

Musa

El-Bashir

Sani-Bello

et al. 2021

Clinical Diabetology

View full text Add to dashboard Cite

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Prevalence of dyslipidemia among persons with type 2 diabetes in Africa: a systematic review and meta-analysis

Ekpor,

Addo-Mensah,

Akyirem

2024

Annals of Medicine &Amp; Surgery

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Background: Dyslipidemia is an established cardiovascular risk factor in persons with type 2 diabetes (T2D), yet the extent to which these conditions co-occur in Africa is unknown. This systematic review and meta-analysis aimed to determine the prevalence of dyslipidemia among persons with T2D in Africa. Methods: Medline, Embase, Global Health, Scopus, and Web of Science were searched on December 5, 2023. This review adhered to the PRISMA guidelines and was prospectively registered on PROSPERO. The prevalence data for dyslipidemia was pooled through a random-effects meta-analysis. We assessed heterogeneity and publication bias using I 2 statistics and Egger’s test, respectively. Results: Our search identified 8035 records, of which 60 articles involving 20,034 individuals with T2D were included in this review. The pooled prevalence of dyslipidemia recorded 38.6% (95% CI: 34.1–43.4) for high TC (≥ 5.2 mmol/L), 52.7% (95% CI: 44.2–61.1) for high LDL-C (≥ 2.6 mmol/L), 43.5% (95% CI: 37.1–50.0) for low HDL-C (< 1.0 mmol/L in men and < 1.3 mmol/L in women), and 37.4% (95% CI: 32.2–42.9) for high TG (≥ 1.7 mmol/L). Subgroup analysis based on gender indicated a notably higher prevalence of dyslipidemia among females compared to males. Conclusion: Dyslipidemia is prevalent among persons with T2D in Africa. This highlights the need for early screening, diagnosis, and management of dyslipidemia to mitigate the risk of cardiovascular complications in this population.

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Glycaemic control among type 2 diabetes patients in sub-Saharan Africa from 2012 to 2022: a systematic review and meta-analysis

Lubaki

Omole

Francis

2022

Diabetol Metab Syndr

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Background There is an increased burden of diabetes globally including in sub-Saharan Africa. The literature shows that glycaemic control among type 2 diabetes patients is poor in most countries in sub-Saharan Africa. Understanding the factors influencing glycaemic control in this region is therefore important to develop interventions to optimize glycaemic control. We carried out a systematic review to determine the prevalence and factors associated with glycaemic control in sub-Saharan Africa to inform the development of a glycaemic control framework in the Democratic Republic of the Congo. Methods We searched five databases (African Index Medicus, Africa-Wide Information, Global Health, PubMed, and Web of Science) using the following search terms: type-2 diabetes, glycaemic control, and sub-Saharan Africa. Only peer-reviewed articles from January 2012 to May 2022 were eligible for this review. Two reviewers, independently, selected articles, assessed their methodological quality using Joanna Briggs checklists, and extracted data. A meta-analysis was performed to estimate the prevalence of glycaemic control. Factors associated with glycaemic control were presented as a narrative synthesis due to heterogeneity as assessed by the I2. Results A total of 74 studies, involving 21,133 participants were included in the review. The pooled prevalence of good glycaemic control was 30% (95% CI:27.6–32.9). The glycaemic control prevalence ranged from 10–60%. Younger and older age, gender, lower income, absence of health insurance, low level of education, place of residence, family history of diabetes, longer duration of diabetes, pill burden, treatment regimen, side effects, use of statins or antihypertensives, alcohol consumption, smoking, presence of comorbidities/complications, and poor management were associated with poor glycaemic control. On the other hand, positive perceived family support, adequate coping strategies, high diabetes health literacy, dietary adherence, exercise practice, attendance to follow-up, and medication adherence were associated with good glycaemic control. Conclusion Suboptimal glycaemic control is pervasive among patients with type-2 diabetes in sub-Saharan Africa and poses a significant public health challenge. While urgent interventions are required to optimize glycaemic control in this region, these should consider sociodemographic, lifestyle, clinical, and treatment-related factors. This systematic review and meta-analysis protocol is registered in PROSPERO under CRD 42021237941.

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Hypogonadism and associated risk factors in male patients with type 2 diabetes mellitus attending the diabetic clinic of Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia

Cited by 4 publications

References 29 publications

Hypergonadotropic hypogonadism in Nigerian men with type 2 diabetes mellitus

Hypergonadotropic hypogonadism in Nigerian men with type 2 diabetes mellitus

Prevalence of dyslipidemia among persons with type 2 diabetes in Africa: a systematic review and meta-analysis

Glycaemic control among type 2 diabetes patients in sub-Saharan Africa from 2012 to 2022: a systematic review and meta-analysis

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