Hypogonadism in chronic obstructive pulmonary disease

Balasubramanian, Vijay; Naing, Soe

doi:10.1097/mcp.0b013e32834feb37

Cited by 65 publications

(63 citation statements)

References 51 publications

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“…Previous studies have reported low T concentrations in men with COPD [24,25]. One cross-sectional study assessed FEV1, FVC and total T in 83 men with stable COPD, 20 with exacerbations of COPD and 30 age-matched controls [26].…”

Section: Discussionmentioning

confidence: 99%

Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community‐dwelling men

Mohan

Knuiman

Divitini

et al. 2015

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community‐dwelling men

Mohan

Knuiman

Divitini

et al. 2015

Clinical Endocrinology

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“…Sex hormone disturbances are common in COPD; a recent review estimated the prevalence of testosterone deficiency in male COPD patients between 22 % and 69 % [108]. The cause of this deficiency is multifactorial and it includes chronic hypoxia, disease severity, smoking, corticosteroid therapy, chronic inflammation and aging itself [109].…”

Section: Androgen Deficiencymentioning

confidence: 99%

Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology

2014

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Chronic obstructive pulmonary disease (COPD) is a major health problem, with increasing morbidity and mortality. There is a growing literature regarding the extra-pulmonary manifestations of COPD, which can have a significant impact on symptom burden and disease progression. Anaemia is one of the more recently identified co-morbidities, with a prevalence that varies between 4.9% and 38% depending on patient characteristics and the diagnostic criteria used. Systemic inflammation seems to be an important factor for its establishment and repeated bursts of inflammatory mediators during COPD exacerbations could further inhibit erythropoiesis. However, renal impairment, malnutrition, low testosterone levels, growth hormone level abnormalities, oxygen supplementation, theophylline treatment, inhibition of angiotensin-converting enzyme and aging itself are additional factors that could be associated with the development of anaemia. The present review evaluates the published literature on the prevalence and significance of anaemia in COPD. Moreover, it attempts to elucidate the reasons for the high variability reported and investigates the complex pathophysiology underlying the development of anaemia in these patients.

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“…The mechanism of hypogonadism in COPD was considered to be multifactorial and many factors such as aging, obesity, systemic inflammation, hypoxemia, hypercapnia, and administration of glucocorticoids were suggested to contribute toward the pathogenesis of such a condition [30,31]. Patients with severe disease in the present study had significantly lower total testosterone and FSH in comparison with their controls with normal pulmonary function, whereas patients with mild and moderate disease did not show such a decrease in the total testosterone level compared with their controls.…”

Section: Figurementioning

confidence: 99%

“…between the symptoms of LOH and symptoms of both aging and COPD, and will prevent overdescription of testosterone replacement therapy [30].…”

Section: Figurementioning

confidence: 99%

Assessment of late-onset hypogonadism among male patients with chronic obstructive pulmonary disease

Youssef¹,

Dayem²,

Abouelezz³

et al. 2013

Human Andrology

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BackgroundChronic obstructive pulmonary disease (COPD) is now considered a systemic disease that affects organs beyond the lungs and airways. The endocrine functions, primarily the gonads, are affected in COPD. PurposeTo assess late-onset hypogonadism (LOH) among male patients with COPD. Materials and methodsThis case-control study included 90 male patients with different degrees of COPD and another 90 age-matched and sex-matched control participants with normal pulmonary function that were subjected to assessment of symptoms of hypogonadism and measurement of free and total testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), and dehydroepiandrosterone-sulfate (DHEAS). ResultsSerum levels of FSH, LH, DHEAS, total, and free testosterone of patients with mild COPD were nonsignificantly different from those of controls. In moderate disease, only DHEAS was significantly lower in comparison with the controls. Patients with severe COPD had significantly lower FSH and total testosterone levels in comparison with the controls. There was a positive correlation between pulmonary function tests and serum levels of sex hormones. There was a significant relation between the severity of COPD and total and free testosterone, DHEAS, and FSH levels, with the lowest levels of hormones in the severe grade. Twenty-five percent of patients with COPD fulfilled the diagnostic criteria of LOH versus 10% in their age-matched controls. Conclusion LOH is more common in men with COPD and occurs at a younger age than their matched controls with normal pulmonary functions. The severity of the disease leads to increased incidence of LOH. Therefore, screening for hypogonadism in patients with severe COPD is recommended.

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Hypogonadism in chronic obstructive pulmonary disease

Abstract: The relationship between hypogonadism and COPD still remains poorly understood. The current literature is at best circumstantial.

Cited by 65 publications

References 51 publications

Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community‐dwelling men

Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community‐dwelling men

Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology

Assessment of late-onset hypogonadism among male patients with chronic obstructive pulmonary disease

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