Hypogonadism in Nigerian men with type 2 diabetes mellitus

Onung, Samuel; Young, Ekenechukwu; Ugwu, Theophilus; Fasanmade, O.A

doi:10.1007/s13410-016-0481-x

Cited by 5 publications

(13 citation statements)

References 24 publications

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“…The study by Young et al [14] from Nigeria on the current issue reinforces the findings of earlier studies from Asia and America and supports a similar contribution of testosterone deficiency to CV burden in countries from the African continent as well. In a cross-sectional study that attempts to determine the prevalence, types, and association of hypogonadism in 108 Nigerian men with established diabetes mellitus, the authors found a tenfold higher prevalence of hypogonadism (38.9 vs 3.6%) among male patients with type 2 DM in Nigeria.…”

Section: # Research Society For Study Of Diabetes In India 2017supporting

confidence: 87%

Hypogonadism and diabetes mellitus - Implications for cardiovascular risk

Madhu

2017

Int J Diabetes Dev Ctries

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It is well recognized that hypogonadism is common in diabetes mellitus (DM) [1][2][3]. However, most of the earlier reports have been in the context of sexual dysfunction particularly resulting in erectile dysfunction (ED) in diabetic men [2]. While ED is an important cause of morbidity in these individuals, there could be other health consequences that also require urgent attention. Testosterone deficiency can affect several facets of the well-being of diabetic patients including sexual performance, mental health, and quality of life [4]. More recently, studies have also focussed on issues that could impact the cardiovascular (CV) and bone health of those affected with DM. Several studies have suggested that hypogonadism particularly in diabetic men is associated with insulin resistance (IR) [5] and a higher occurrence of metabolic syndrome [6]. Clamp studies in patients of DM with testosterone deficiency have revealed a significant reduction in insulin-mediated glucose uptake that has been shown to improve with gonadal hormone replacement in these hypogonadal individuals [7]. These observations suggest that hypogonadism could be associated with significant CV risk among diabetic subjects.It is well known that DM enhances CV risk manifold and that several factors associated with DM such as abdominal obesity, dyslipidemia, and hypertension drive diabetesrelated atherosclerosis and CV risk. However, it is also known that a large part of the CV risk associated with DM remains unexplained by conventional risk factors and the search for newer risk factors is still on. There have been recent reports of hypogonadism in 30-40% of male subjects with DM [1][2][3] particularly in those with evidence of coronary artery disease (CAD) [8]. A significant positive correlation has also been reported between hypogonadism and CAD [8] and atherosclerosis [9]. Coupled with its documented association with insulin resistance and metabolic syndrome, these findings would suggest that testosterone deficiency is not only an important CV risk factor but could also be a major contributor to the CV burden associated with diabetes. The CV risk associated with testosterone deficiency is believed to be related to its known effect on body fat and lean body mass [10] as well as to other independent effects [11] which are not fully understood.Other studies in men without DM have also reported an association of low testosterone levels and increased CV risk [11] and increased carotid intima media thickness (CIMT) [12]. Testosterone is believed to improve coronary blood flow in men and has been shown to induce vasodilatation in isolated rabbit aorta [13].The study by Young et al. [14] from Nigeria on the current issue reinforces the findings of earlier studies from Asia and America and supports a similar contribution of testosterone deficiency to CV burden in countries from the African continent as well. In a cross-sectional study that attempts to determine the prevalence, types, and association of hypogonadism in 108 Nigerian men with established ...

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Section: # Research Society For Study Of Diabetes In India 2017supporting

confidence: 87%

Hypogonadism and diabetes mellitus - Implications for cardiovascular risk

Madhu

2017

Int J Diabetes Dev Ctries

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“…Several studies have reported hypogonadism to be associated with T2DM [13][14][15][16][17]. In cross-sectional studies conducted in Nigeria, Ogbera et al reported the prevalence of hypogonadism to be 36% among type 2 diabetic men attending Gbagada General Hospital Lagos.…”

Section: Introductionmentioning

confidence: 99%

“…In cross-sectional studies conducted in Nigeria, Ogbera et al reported the prevalence of hypogonadism to be 36% among type 2 diabetic men attending Gbagada General Hospital Lagos. Meanwhile, Onung et al and Ugwu et al reported the prevalence of hypogonadism to be 38.9% and 52.5% in men with T2DM in Lagos and Ile-Ife, respectively [15][16][17]. In South Africa, Kemp et al reported the prevalence of androgen deficiency symptoms to be 94.7% among male diabetics aged 50 years and above [18].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported that hypogonadotropic hypogonadism accounts for the majority of the cases of hypogonadism in T2DM [16,20,21]. However, primary hypogonadism (hypergonadotropic hypogonadism) has been reported with higher frequency in people with diabetes compared to non-diabetics [22].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, few studies have reported on the pattern of hypogonadism in men with T2DM in Sub-Saharan Africa using basal gonadotropins (LH and FSH) [16,22]. There is currently no available data reporting the pattern of hypogonadism in men with type 2 diabetes mellitus using a GnRH stimulation test in Sub-Saharan Africa, particularly of importance in those with borderline gonadotropin levels.…”

Section: Introductionmentioning

confidence: 99%

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Hypergonadotropic hypogonadism in Nigerian men with type 2 diabetes mellitus

Musa

El-Bashir

Sani-Bello

et al. 2021

Clinical Diabetology

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Background. Studies have reported a higher prevalence of hypogonadism in men with type 2 diabetes mellitus (T2DM) than non-diabetic men. The pattern of hypogonadism in men with T2DM using gonadotropin-releasing hormone (GnRH) stimulation test in Sub-Saharan Africa is unknown. Objective. This study was conducted to determine the prevalence and pattern of hypogonadism in Nigerian men with T2DM. Methods. A cross-sectional study involving 358 men with T2DM and 179 non-diabetic men as controls. Androgen Deficiency in the Ageing Male (ADAM) questionnaire was administered. luteinizing hormone (LH) and follicle-stimulating hormone (FSH) both at 0 hours and 4 hours after subcutaneous buserelin injection, fasting total testosterone (TT), fasting plasma glucose and glycated haemoglobin were measured. Ninety-nine men with T2DM selected by randomization using a computer underwent GnRH stimulation test, with subcutaneous injection of 100 micrograms of buserelin. Results. The mean TT of T2DM men was significantly lower compared to the controls (8.79 ± 3.35 nmol/l vs 15.41 ± 3.79 nmol/L, p < 0.001). The prevalence of hypogonadism in T2DM men was 80.4%, comprising 38.5% of severe hypogonadism and 41.9% mild hypogonadism. The mean LH and FSH levels were significantly higher in T2DM men than the controls (9.62 ± 6.82 IU/l vs 8.24 ± 5.91 IU/l, p = 0.022 and 8.50 ± 8.17 IU/l vs 5.17 ± 3.89 IU/L, p < 0.001 respectively). There was a statistically significant exaggerated response in mean (±SD) LH and FSH levels at 4 hours after buserelin injection compared to the 0-hour levels (58.58 ± 40.72 IU/l vs 8.38 ± 6.10 IU/L, p < 0.001 and 23.03 ± 18.02 IU/l vs 8.41 ± 7.45 IU/L, p < 0.001 respectively) in men with T2DM who had GnRH stimulation tests. Conclusion. This study shows that the prevalence of hypogonadism in men with T2DM is significantly higher than in non-diabetic men with mild hypogonadism accounting for most cases. Hypergonadotropic hypogonadism occurs more frequently in men with T2DM

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Effect of some Medical Plant Extracts and Chemicals on Hormones of Female Rats

Al-Ameen,

Al-Azzawi,

Fadhil

2023

IOP Conf. Ser.: Earth Environ. Sci.

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The study was carried out on 45 sexually mature female albino rats at the age of 7-8 weeks and weighing 160-180 ± 10 gm., nine treatments were used in this study, where five rats were isolated for control treatment (without infection). The remaining rats were injected (Subcutaneous) with Indian-made Alloxan, which was prepared at the time of injection at a dose of 100 mg/kg of body weight. The purpose of this study was to determine the effect of extracts of medical plants (Curcumin, Origanum majorana, and Vitex aguns-castus) at 50-100 mg/kg body weight and chemotherapy (metformin at 50 mg/kg body weight) on hormones. The results showed a significant increase in LH hormone in the T3, T4, T5, T7, and T9 treatments compared with the T2 treatment. A significant increase in FSH was observed in T3, T4, T5, T6, T7, and T9 treatments compared with T2 treatment. The results of the statistical analysis indicated a significant increase in progesterone in the T3, T5, T7, and T9 treatments compared with the T2 treatment. While T3, T5, and T9 treatments were significantly superior to T2, T4, T6, T7, and T8 treatments in terms of estrogen hormone. While a significant increase in cortisol was observed in the T2 treatment compared with the rest of the treatments. The aim of this study was to investigate the effect of aqueous extracts of Curcumin, Origanum majorana and Vitex aguns-castus leaves on the sex hormones of female rats. The results have shown that the aqueous extracts have a positive effect on hormones in female rats.

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Hypogonadism in Nigerian men with type 2 diabetes mellitus

Cited by 5 publications

References 24 publications

Hypogonadism and diabetes mellitus - Implications for cardiovascular risk

Hypogonadism and diabetes mellitus - Implications for cardiovascular risk

Hypergonadotropic hypogonadism in Nigerian men with type 2 diabetes mellitus

Effect of some Medical Plant Extracts and Chemicals on Hormones of Female Rats

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