Hypohaptoglobinaemia as an Epidemiological and Clinical Indicator for Malaria

Rougemont, André; Bouvier, M.; Perrin, Luc; Yerly, Sabine; Brenner, E.; Srivastava, Indresh K.; Dumbo, O.; Soula, G; Tamoura, B.; Dolo, Amagana; Kodio, B.; Ranque, P

doi:10.1016/s0140-6736(88)90186-9

Cited by 37 publications

(20 citation statements)

References 15 publications

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“…Hp expression is stimulated by the proinflammatory cytokine, IL-6 (124); so, circulating Hp levels can be used as a clinical marker of infection (high Hp) (9). On the other hand, severe hemolysis rapidly depletes Hp levels (140,169). On the surface of circulating monocytes or tissue macrophages, CD163 binds to Hb complexed with Hp at high affinity or, when Hp is depleted, to free Hb with low affinity (151).…”

Section: Role Of Ho-1 In the Mononuclear Phagocyte Systemmentioning

confidence: 99%

The Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1

Hull

Agarwal

George

2014

Antioxidants & Redox Signaling

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Significance: Heme oxygenase-1 (HO-1) is a potential therapeutic target in many diseases, especially those mediated by oxidative stress and inflammation. HO-1 expression appears to regulate the homeostatic activity and distribution of mononuclear phagocytes ( MP) in lymphoid tissue under physiological conditions. It also regulates the ability of MP to modulate the inflammatory response to tissue injury. Recent Advances: The induction of HO-1 within MP-particularly macrophages and dendritic cells-modulates the effector functions that they acquire after activation. These effector functions include cytokine production, surface receptor expression, maturation state, and polarization toward a pro-or anti-inflammatory phenotype. The importance of HO-1 in MP is emphasized by their expression of specific receptors that primarily function to ingest heme-containing substrate and deliver it to HO-1. Critical Issues: MP are the first immunological responders to tissue damage. They critically affect the outcome of injury to many organ systems, yet few therapies are currently available to specifically target MP during disease pathogenesis. Elucidation of the role of HO-1 expression in MP may help to direct broadly applicable therapies to clinical use that are based on the immunomodulatory capabilities of HO-1. Future Directions: Unraveling the complexities of HO-1 expression specifically within MP will more completely define how HO-1 provides cytoprotection in vivo. The use of models in which HO-1 expression is specifically modulated in bone marrow-derived cells will allow for a more complete characterization of its immunoregulatory properties.

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Section: Role Of Ho-1 In the Mononuclear Phagocyte Systemmentioning

confidence: 99%

The Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1

Hull

Agarwal

George

2014

Antioxidants & Redox Signaling

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“…Such proteins have been used in malaria studies at both the individual and the population level (CHIEWSILP et al, 1988;GILLESPIE et al, 1991;GRANINGER et al, 1992;ROUGEMONT et al, 1988;SISAY et al, 1992). C-reactive protein (CRP) is the classical acute phase reactant and has been advocated as a replacement for the erythrocyte sedimentation rate as a general screening test for disease (FLECK & MYERS, 1985).…”

Section: Introductionmentioning

confidence: 99%

“…In studies in endemic areas, ROUGEMONT et al (1988) andTRIPE et al (1985) reported that low haptoglobin levels reflect recent parasitaemia and malariainduced haemolysis, whilst other disease conditions result in increased haptoglobin levels.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of C-reactive protein and haptoglobin as malaria episode markers in an area of high transmission in Africa

Hurt

Smith

Tanner

et al. 1994

Transactions of the Royal Society of Tropical Medicine and Hygi

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Field studies of malaria in endemic areas frequently. use the presence or levels of parasitaemia, together with the measurement of fever, as the primary criteria Rlth which to identify cases. However, since malaria cases do not always present with measurable fever, and since asymptomatic parasitaemia occurs, additional episode markers might be useful epidemiological tools. We have measured the C-reactive protein and haptoglobin levels in paediatric patients presenting to a village health post in the Kilombero District in Tanzania and in convalescent sera from the same patients, in order to evaluate these acute-phase reactants as alternative markers of Plasmodium falciparum episodes. Among afebrile patients, C-reactive protein levels were highly correlated with parasite density. High C-reactive protein levels are therefore probably indicative of recent clinical malaria cpisodcs in currently afebrile individuals with high parasite densities. An appropriate case definition for malaria in epidemiological studies in endemic areas might therefore be hyperparasitaemia accompanied by either, or both, measurable fever and raised C-reactive protein levels. This would give less biased estimates of the overall burden of malaria morbidity than does a definition which requires measurable fever. Levels of haptoglobin were highly negatively correlated with parasitaemia, but did not appear to be useful episode markers because this correlation was probably not related to acute morbidity. However, haproglobin can be useful to assess at community level The impact of interventions on parasitaemia.

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“…Because of the close association between ahaptoglobiwere responsible for the high prevalence of ahaptoglobinaemia and malaria, ROUGEMONT et al (1988) suggested naemia in some populations (ALLISON, 1959), but others that assay of haptoglobin levels could be used as an indihave argued that environmental factors are more importrect measurement of malaria infection and they have ant (CURTAIN et al, 1965;GIBLETT et al, 1966). There shown how, in an area of Mali, seasonal changes in the is now strong evidence that malaria and ahaptoglobinaehaptoglobin index paralleled those of the prevalence and mia are closely related.…”

mentioning

confidence: 99%

“…JOUR et al, 1982;TRAPE et al, 1985). Furthermore, the fore, we have investigated whether measurement of occurrence of ahaptoglobinaemia in susceptible populaserum haptoglobin, using a simple and rapid enzymetions can be completely, or almost completely, elimilinked immunosorbent assay (ELISA), could be used to nated by the administration of malaria give an indirect assessment of the impact of a malaria chemo-prophylaxis (ROUGEMONT et al, 1988;BOREHAM control programme. et al, 1981;TRAPE et al, 1985).…”

mentioning

confidence: 99%

Measurement of serum haptoglobin as an indicator of the efficacy of malaria intervention trials

Sisay

Byass

Snow

et al. 1992

Transactions of the Royal Society of Tropical Medicine and Hygi

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Serum haptoglobin levels were measured by an enzyme-linked immunosorbent assay in Gambian children who participated in 3 malaria intervention trials with untreated or impregnated bed nets. In one study, in which a significant effect on clinical malaria was observed, the mean serum haptoglobin level was significantly higher in the intervention than in the control group. In the other 2 studies, in which no significant protection was observed, mean haptoglobin levels were similar in intervention and control groups. Measurement of serum haptoglobin may provide a useful indirect measure of the effectiveness of malaria control programmes.

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Hypohaptoglobinaemia as an Epidemiological and Clinical Indicator for Malaria

Cited by 37 publications

References 15 publications

The Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1

The Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1

Evaluation of C-reactive protein and haptoglobin as malaria episode markers in an area of high transmission in Africa

Measurement of serum haptoglobin as an indicator of the efficacy of malaria intervention trials

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