Hypokalemia-Induced Rhabdomyolysis From Budesonide Therapy in Crohn's Disease

Mansour, Ramy; Mandiga, Pujyitha; Thigpin, Derek

doi:10.14309/crj.0000000000000201

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In adults, a handful of these cases have been documented in association with primary aldosteronism, 11 diuretics and laxative abuse, 12,13 glycyrrhiza and natural licorice-induced pseudohyperaldosteronism, 14,15 and meropenem and budesonide therapies. 16,17 Even fewer cases of hypokalemia-induced rhabdomyolysis are reported in the pediatric population. Most of these cases were in patients with congenital tubular disorders, such as Bartter and Gitelman syndromes or renal tubular acidosis.…”

Section: Discussionmentioning

confidence: 99%

Hypokalemia-Induced Rhabdomyolysis in a Child with Autism Affected by the COVID-19 Pandemic

Cao

Gaffney

Marcus

2021

J Dev Behav Pediatr

View full text Add to dashboard Cite

Objective:Pediatric patients with autism spectrum disorder (ASD) often have coexisting feeding disorders. We hope to emphasize the significant implications that these feeding disorders can have on this patient population through a unique case of hypokalemia-induced rhabdomyolysis.Method:We present a unique case of a 3-year-old boy with ASD and a longstanding history of food selectivity whose routine was disrupted during the COVID-19 pandemic resulting in avoidant/restrictive food intake disorder and severe undernutrition, who presented with profound hypokalemia and was subsequently found to have elevated muscle enzymes consistent with rhabdomyolysis despite only subtle complaints of difficulty walking.Results:The patient was treated with aggressive hydration, electrolyte therapy, and nasogastric tube feeds, which resulted in clinical and biochemical evidence of improvement. He was also reconnected to ASD-related care services that had lapsed during the COVID-19 pandemic.Conclusion:This case exemplifies the adverse impact that feeding disorders can have on patients with ASD, particularly in the setting of stressors such as a global pandemic, and is also the first documented pediatric case of rhabdomyolysis secondary to hypokalemia from severe undernutrition. It demonstrates that physicians should have a low threshold to assess for clinical and laboratory evidence of rhabdomyolysis in patients with profound hypokalemia because symptoms of hypokalemia-induced rhabdomyolysis can often be subtle, which can delay diagnosis and thereby increase the risk for life-threatening complications from extensive muscle damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Hypokalemia-Induced Rhabdomyolysis in a Child with Autism Affected by the COVID-19 Pandemic

Cao

Gaffney

Marcus

2021

J Dev Behav Pediatr

View full text Add to dashboard Cite

show abstract

“…For example, a study demonstrated that potassium depletion caused by diuretic therapy could result in severe hypokalemia, particularly among patients with heart failure [9]. Another study reported that hypokalemia induced by laxative abuse could lead to severe muscle weakness and rhabdomyolysis [10].…”

Section: American Journal Of Biomedical Science and Researchmentioning

confidence: 99%

Critical Hypokalemia: A Complex Clinical Journey

Ranasinghe

2023

AJBSR

View full text Add to dashboard Cite

Hypokalemia, characterized by low potassium levels in the blood, is a condition that can have severe consequences for patients, including cardiac arrhythmias and muscle weakness. Extreme hypokalemia, although rare, can lead to paralysis, cardiac arrest, and even death. The purpose of this project is to better understand hypokalemia, its presentation, and how it impacts different organ systems in the body. We will do this by analyzing a unique case of extreme hypokalemia. We will provide a concise framework for managing patients with similar presentations.

show abstract

Hypokalemia-Induced Rhabdomyolysis From Budesonide Therapy in Crohn's Disease

Cited by 2 publications

References 11 publications

Hypokalemia-Induced Rhabdomyolysis in a Child with Autism Affected by the COVID-19 Pandemic

Hypokalemia-Induced Rhabdomyolysis in a Child with Autism Affected by the COVID-19 Pandemic

Critical Hypokalemia: A Complex Clinical Journey

Contact Info

Product

Resources

About