Hypokalemic paralysis as a primary presentation of Fanconi′s syndrome and distal renal tubular acidosis in a patient with primary Sjogren′s syndrome

Basavaraj, Anita; Badave, Rohan Ramesh; Kadam, Manasi; Kadam, Deelip

doi:10.4103/0028-3886.158264

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…In contrast to HT and SLE, tubulointerstitial renal involvement is a relative common manifestation of SS with an estimated prevalence of 5% to 10%. 15 – 20 The pathogenesis of dRTA in SS is not completely understood, but some studies suggest that the absence of H + -ATPase pump and the presence of autoantibodies to intercalated cells in the collector duct and against carbonic anhydrase in the distal nephron are the pathogenic mechanisms. 21 , 22 Besides, there is a prominent interstitial infiltrate of lymphocytes and plasma cells, 18 , 19 , 23 which invade the tubular membrane and lining epithelium, change the architecture, and generate a secretory defect in the distal tubules.…”

Section: Discussionmentioning

confidence: 99%

Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases

Velarde-Mejía

Gamboa-Cárdenas

Ugarte‐Gil

et al. 2017

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Acute hypokalemic paralysis is a rare and potentially fatal condition, with few related causes, one of which highlights distal renal tubular acidosis (dRTA). Distal renal tubular acidosis is a rare complication of several autoimmune diseases such as systemic lupus erythematosus, Sjögren’s syndrome, and Hashimoto thyroiditis. We report a case of a lupic patient who presented rapidly progressive quadriparesis in the context of active renal disease. Research revealed severe refractory hypokalemia, metabolic acidosis, and alkaline urine suggestive of dRTA. We diagnosed Sjögren’s syndrome based on sicca symptoms, an abnormal salivary glands’ nuclear scan and the presence of anti-Ro/SSA and anti-La/SSB. In addition, the finding of thyroid peroxidase, thyroglobulin antibodies, and hypothyroidism led us to the diagnosis of Hashimoto thyroiditis. Due to the active renal involvement on the context of systemic lupus erythematosus and Sjögren’s syndrome, the patient received immunosuppression with rituximab, resulting in a progressive and complete improvement.

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Section: Discussionmentioning

confidence: 99%

Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases

Velarde-Mejía

Gamboa-Cárdenas

Ugarte‐Gil

et al. 2017

Clin Med�Insights�Arthritis�Musculoskelet Disord

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“…These participants were selected via a convenient sampling method in the Mysuru district, India. Furthermore, the study was approved based on the “Ethical Guidelines of Bio-Behavioral Research Involving Human Subjects” 16 and approved by the Ethical Committee at the All India Institute of Speech and Hearing, Mysuru (WF-179/2018-19). These participants were enrolled in the study after meeting several inclusion criteria: (1) diagnosis of aphasia confirmed based on the Western Aphasia Battery in Kannada (WAB-K) 17 ; (2) native Kannada speakers; (3) right-handedness premorbid to stroke; (4) negative history of a learning disorder or drug or alcohol addiction; (5) minimum of 50% scores in the auditory-verbal comprehension section; (6) no impairment in cognition, confirmed via the Mini-Mental State Examination (MMSE) 18 ; and (7) no sign of apraxia, confirmed through the administration of an apraxia section of the WAB-K (see Supplementary Table S1 , available in the online version only, for demographic details of the participants).…”

Section: Methodsmentioning

confidence: 99%

“…Accomplishing generalization becomes the key goal in any of the word retrieval intervention approaches of aphasia. 16 Hence, the current study investigated the influence of word retrieval treatment on discourse skills across pre-, mid-, and posttreatment phases; we also investigated the effect of word retrieval treatment following treatment cessation.…”

Section: Introductionmentioning

confidence: 99%

Impact of Semantic Cueing of Verb and Its Thematic Role on Discourse Skills of Persons with Aphasia

Puttanna,

Puri,

Swamy

2024

Journal of Health and Allied Sciences NU

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Introduction Understanding the relationship between word retrieval treatment and discourse skills is deemed pivotal, as it gives the individuals a more naturalistic linguistic performance. Objective The aim of this study was to unravel the impact of word retrieval treatment on discourse skills. Method and Materials Semantic cueing of verbs and its thematic role (SCVTr) treatment were rendered to 11 persons with aphasia (PWAs). Subsequent to therapy, discourse skills were evaluated in the pretreatment, midtreatment, posttreatment, and follow-up phases using both qualitative (discourse analysis scale) and quantitative (T-unit analysis) measures. The follow-up phase in the study began after 1 month of cessation of treatment. Results The outcome of the study evinced statistical differences in the discourse skills in both qualitative and quantitative measures of discourse between pre-, mid-, and posttreatment phases. However, no statistical difference was found between the posttreatment and follow-up phases across qualitative and quantitative measures. This signifies there are no differences in discourse skills after the cessation of treatment. Conclusion The study findings seemed to be novel, as the study explored the impact of word retrieval treatment on discourse skills. It also sheds light on the importance of discourse analysis and the ways of measuring it in PWAs. Overall, the study finding seems conducive as it posits positive outcomes in both qualitative and quantitative measures of discourse skills following word retrieval treatment.

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A Case of Sjogren’s Syndrome during Pregnancy with Hypokalemia as the First Symptom Misdiagnosed as Hyperemesis Gravidarum

徐¹

2021

ACM

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Hypokalemic paralysis as a primary presentation of Fanconi′s syndrome and distal renal tubular acidosis in a patient with primary Sjogren′s syndrome

Cited by 3 publications

References 4 publications

Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases

Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases

Impact of Semantic Cueing of Verb and Its Thematic Role on Discourse Skills of Persons with Aphasia

A Case of Sjogren’s Syndrome during Pregnancy with Hypokalemia as the First Symptom Misdiagnosed as Hyperemesis Gravidarum

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