Hypokalemic periodic paralysis presenting as asymmetric focal flaccid paralysis: A case report and literature review

Ma, Guozhong; Ma, Guofen; He, Jia; Xian, Haiying; Xie, Yuan

doi:10.1016/j.heliyon.2023.e14988

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Unlike in our case, the patients in some previous reports had monoparesis. 15 , 16 Other reported atypical patterns of muscle weakness associated with hypokalaemia include right hand weakness progressing to paraparesis, 17 right arm weakness with subsequent development of tetraparesis 18 and left thumb weakness. 19 Table 2 provides information on the clinical features, degree of hypokalaemia and how hypokalaemic paralysis was diagnosed in the aforementioned case reports.…”

Section: Discussionmentioning

confidence: 99%

An unusual stroke mimic: A case report

Adjei,

Amponsah,

Atenebano

2023

SAGE Open Medical Case Reports

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Hypokalaemic paralysis is a rare disorder characterized by rapid onset of symmetrical flaccid skeletal muscle weakness in the presence of reduced serum potassium levels. It is categorized as primary or secondary depending on the aetiology. Asymmetric or unilateral muscle weakness in hypokalaemic patients is a rare presentation. In patients with comorbid cardiovascular risk factors, this atypical manifestation can mimic acute stroke. Only a few of such cases have been reported in the literature. This report discusses the case of a 46-year-old hypertensive Ghanaian woman who presented to a District Hospital with sudden-onset right-sided flaccid weakness and a high blood pressure. Acute stroke was ruled out with computed tomography scan of the brain. Further laboratory evaluation demonstrated reduced serum potassium level, which was corrected with subsequent dramatic resolution of the muscle weakness.

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Section: Discussionmentioning

confidence: 99%

An unusual stroke mimic: A case report

Adjei,

Amponsah,

Atenebano

2023

SAGE Open Medical Case Reports

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Impact of genetic mutations in hypokalemic periodic paralysis: Diagnosis and clinical management

Blacio Villa,

Naranjo Castillo,

Sogso Chano

et al. 2024

Salud, Ciencia y Tecnología - Serie de Conferencias

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Neuromuscular diseases encompass a variety of disorders affecting muscular and nervous function, with numerous genetic conditions manifesting in diverse clinical forms. Among these disorders, periodic paralyses stand out due to their complexity and rarity, representing a significant challenge for diagnosis and management. This study focuses on hypokalemic periodic paralysis, a rare and complex condition, aiming to identify and characterize the associated genetic mutations to improve the diagnosis and treatment of the disease.Mixed methods were employed, including genetic analysis using next-generation sequencing and clinical evaluation through interviews, medical record reviews, and specific questionnaires. The results revealed that mutations in the CACNA1S and SCN4A genes play a crucial role in the paralysis, allowing for a more precise approach to diagnosis and treatment. Additionally, new clinical protocols based on these findings were designed and implemented, including personalized recommendations and training for medical staff. The study highlights the importance of integrating genetic analysis into the diagnosis and management of the condition. The implementation of these protocols has significantly improved patients' quality of life and efficiency in medical resource management. Furthermore, the success of these strategies emphasizes the need for continued education and updates for medical personnel and opens new possibilities for applying these approaches to other genetic neuromuscular diseases

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Hypokalemic periodic paralysis presenting as asymmetric focal flaccid paralysis: A case report and literature review

Cited by 2 publications

References 9 publications

An unusual stroke mimic: A case report

An unusual stroke mimic: A case report

Impact of genetic mutations in hypokalemic periodic paralysis: Diagnosis and clinical management

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