Hypokalemic rhabdomyolysis associated with Bartter's syndrome

Bierbach, H; Bohl, J.; Göldner, H.; Majdandzic, J.

doi:10.1007/bf01488972

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…Therefore, they are at risk of developing rhabdomyolysis and acute renal failure, as described by Nishihara et al [4], Bierbach et al [5], and van der Loos [6]. The patients described in these reports were all adults-46 years old, 45 years old, and 26 years old, respectivelyaffected either by Gitelman's syndrome (the former case) or by Bartter's syndrome (the latter two).…”

Section: Discussionmentioning

confidence: 81%

“…To date, Bartter's syndrome presenting with hypokalemic rhabdomyolysis has been described only in two adult patients [4,5]. A further case of rhabdomyolysis and acute renal failure has been reported in a 46-year-old patient affected by Gitelman's syndrome, a disorder characterized by renal hypomagnesaemia and hypocalciuria in addition to the clinical features of Bartter's syndrome [1,6].…”

Section: Introductionmentioning

confidence: 99%

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Hypokalemic rhabdomyolysis in a child with Bartter’s syndrome

et al. 2005

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Hypokalemia represents a rare cause of rhabdomyolysis. Some reports have described a few adult patients affected by Bartter's syndrome and Gitelman's syndrome with rhabdomyolysis due to severe hypokalemia. We report the first pediatric patient with Bartter's syndrome in whom rhabdomyolysis developed when her plasma potassium level was less than 2 mEq/l. Prompt intravenous fluid and potassium prevented tubular damage and acute renal failure. We recommend determining serum creatine phosphokinase in all patients affected by Bartter's syndrome and profound hypokalemia.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Hypokalemic rhabdomyolysis in a child with Bartter’s syndrome

et al. 2005

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“…The course of hypokalemic rhabdomyolysis was complicated by the transient development of moderate to severe acute kidney injury in one patient [15]. Mild hyperkalemia (5.3 mmol/L) was noted in one case [11].…”

Section: Resultsmentioning

confidence: 99%

“…Pertinent secondary references were also considered. Using this research technique, we were able to accumulate 9 cases (5 male and 4 female subjects, ranging in age between 4.0 and 46, median 21 years) of congenital renal tubular disorders complicated by hypokalemic rhabdomyolysis that have been published in peer-reviewed English-language scientific journals [11][12][13][14][15][16][17][18][19] between 1983 and 2008. One patient who was reported twice in the literature was considered only once [12,13].…”

Section: Systematic Review: Data Sourcesmentioning

confidence: 99%

Hypokalemic rhabdomyolysis in congenital tubular disorders: a case series and a systematic review

et al. 2009

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Hypokalemia is a recognized cause of rhabdomyolysis but very few reports document its association with inborn renal tubular disorders. We report our experience with hypokalemic rhabdomyolysis in 5 pediatric patients affected by inborn renal tubular disorders and the results of a careful review of the literature disclosing 9 further cases for a total of 14 patients (8 male and 6 female subjects, aged between 1.6 and 46, median 16 years). The inborn renal tubular disorders underlying rhabdomyolysis were classic distal renal tubular acidosis (n = 7), Gitelman syndrome (n = 5), classic Bartter syndrome (n = 1), and antenatal Bartter syndrome (n = 1). In 8 patients rhabdomyolysis followed an acute intestinal disease, an upper respiratory illness or the discontinuation of regular medication. Five patients experienced two or more episodes of rhabdomyolysis. In 10 patients the underlying renal tubular disorder was recognized concurrently with the episode of rhabdomyolysis or some weeks later. In conclusion some congenital renal tubular disorders predispose to hypokalemic rhabdomyolysis. Prevention of discontinuation of regular medication and electrolyte repair in the context of acute intercurrent illnesses might avoid the development of hypokalemic rhabdomyolysis.

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“…Diabetische Ketoazidose [13], nichtketotische Hyperglykämie [86] und Hypothyreose [35] beeinflussen die Intaktheit der Muskelzellen und den zellulären Energieprozess. Die durch Hypokaliämie induzierte Rhabdomyolyse kann als Nebenwirkung bei einer Vielzahl von Medikamenten auftreten und wurde auch bei Anorexia nervosa [35], Bartter-Syndrom [5], renaler tubulärer Azidose [15], länge-rer parenteraler Ernährung [70] …”

Section: Metabolische Störungenunclassified

Rhabdomyolyse und Myoglobinurie

Lindner

Zierz

2003

Nervenarzt

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Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell components into the circulation, most notably creatine phosphokinase (CK) and myoglobin, and is frequently accompanied by myoglobinuria. Therefore, the term myoglobinuria is often used interchangeably with the term rhabdomyolysis. This disorder may result in potential life-threatening complications such as acute myoglobinuric renal failure, hyperkalemia and cardiac arrest, disseminated intravascular coagulation, and compartment syndrome. The condition is etiologically heterogeneous and may result from a large variety of diseases affecting muscle membranes, membrane ion channels, and muscle energy supply including acquired causes (e.g., exertion, crush injury and trauma, alcoholism, drugs, and toxins) and hereditary causes (e.g., disorders of carbohydrate metabolism, disorders of lipid metabolism, or diseases of the muscle associated with malignant hyperthermia). In many patients with idiopathic recurrent rhabdomyolysis, specific inherited metabolic defects have not been recognized up to now.

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Hypokalemic rhabdomyolysis associated with Bartter's syndrome

Cited by 11 publications

References 24 publications

Hypokalemic rhabdomyolysis in a child with Bartter’s syndrome

Hypokalemic rhabdomyolysis in a child with Bartter’s syndrome

Hypokalemic rhabdomyolysis in congenital tubular disorders: a case series and a systematic review

Rhabdomyolyse und Myoglobinurie

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