Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in Triton WR-1339-induced hyperlipidemic mice

Harnafi, Hicham; Serghini-Caíd, Hana; Bouanani, Nour El Houda; Aziz, Mohammed; Amrani, Souliman

doi:10.1016/j.foodchem.2007.10.062

Cited by 102 publications

(65 citation statements)

References 25 publications

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“…It is hypothesized by many authors that the restoration of catabolic metabolism of triglycerides could be due to an increased stimulation of the lipolytic activity of plasma lipoprotein lipase (LPL). This similar observation has also been reported for a polar soluble fraction of Ocimum basilicum which is reported to significantly reduce the elevated blood concentrations of TGs [36]. The presence of flavonoids like rutin, quercetin, kaempferol in the leaves might also be responsible for hypo cholesterol activity through different mechanisms, which were previously reported by other authors [37][38][39].…”

Section: Discussionsupporting

confidence: 87%

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Gururaja

Mundkinajeddu

Kumar

et al. 2016

Int J Pharm Pharm Sci

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Objective: Moringa oleifera Lam. (Moringaceae), a small rapid growing, evergreen, deciduous tree is an important medicinal plant. Leaves and fruits of this plant are used for various ailments, as a nutritional supplement and also as vegetables. The current study involves in the determination of best combination of the cholesterol-lowering potential of a blend of methanol extracts of M. oleifera leaf and fruits, developed based on in vitro FIC index studies and evaluate the combination of this extracts in hypercholesterolemic animal models. Methods:Leaf and fruit methanol extracts and their combinations were tested in in vitro lipase inhibition assay to determine the best combination using fractional inhibitory concentration (FIC) index. Hypercholesterolemia was induced with Triton WR-1339 (a non-ionic detergent) and with high cholesterol diet for acute and chronic model respectively and the cholesterol-lowering effect of 1:1 blend of M. oleifera leaf and fruits methanol extracts was evaluated. Results:The FIC index values indicated that M. oleifera leaf and fruit extracts blended in 1:1 proportion was the best combination in in vitro lipase inhibition assay. This blend, when evaluated in vivo, showed a significant decrease in serum total cholesterol level from 24 h through 48 h in triton model. In high cholesterol diet model, the extract blend showed a significant reduction in serum triglycerides levels at 3 and 6 w of treatment. Conclusion:The results indicate that the blend of M. oleifera at the tested dose could be lowering cholesterol and triglyceride levels by inhibiting the absorption of cholesterol and can be developed as a standardized blend for dietary supplement market.

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Section: Discussionsupporting

confidence: 87%

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Gururaja

Mundkinajeddu

Kumar

et al. 2016

Int J Pharm Pharm Sci

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show abstract

“…Serum levels of low-density lipoprotein cholesterol (LDL-C) were determined according to the Friedewald formula: LDL-C = TC -(HDL-C + VLDL-C), where VLDL-C is very low-density lipoprotein cholesterol [13]. Atherogenic index (AI) was calculated by the following formula: (TC -HDL-C) / HDL-C [14]; LDL-C / HDL-C ratio was calculated as the ratio of plasma LDL-C to HDL-C levels.…”

Section: Measurementmentioning

confidence: 99%

Prevalence and associated factors of cardio-metabolic risk factors in Iranian seafarers

Baygi

Jensen

Qorbani

et al. 2016

International Maritime Health

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“…It is the major cause of heart disease, stroke, and death in the world. It is well established that elevated blood lipid levels constitute the primary risk factor for atherosclerosis (Harnafi et al, 2008). Many studies have shown that increased cholesterol concentrations in plasma cause coronary atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic effect of fucoidan fromLaminaria japonicain hyperlipidemic rats

Huang

Wen

Gao

et al. 2010

Pharmaceutical Biology

116

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Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in Triton WR-1339-induced hyperlipidemic mice

Cited by 102 publications

References 25 publications

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Prevalence and associated factors of cardio-metabolic risk factors in Iranian seafarers

Hypolipidemic effect of fucoidan fromLaminaria japonicain hyperlipidemic rats

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