Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse

Lee, Hyeung Sik; Yoo, Choon Bo; Ku, Sae Kwang

doi:10.1016/j.fitote.2006.09.004

Cited by 28 publications

(18 citation statements)

References 31 publications

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“…In this study, MLE dose-dependently ameliorated gene expressions of LXRa, LPL, SREBP1c, FAS, C/EBPa, and aP2 and protein levels of nuclear SREBP1c and cytosolic LPL. A previous study demonstrated that Nrf2 activation inhibited up-regulated LXRa activity and LXRa-dependent liver steatosis (Lee et al 2006). Collectively, the results of the current study suggest that MLE attenuates lipid accumulation through the decrease in LXRa-dependent lipogenesis and the increase in lipolysis in HFD-induced NAFLD.…”

Section: Discussionsupporting

confidence: 72%

“…NAFLD is a common chronic liver disease that includes fibrosis, steatosis, hepatocellular ballooning, and inflammation (Hey-Mogensen et al 2012). NAFLD is a progressive disease and is characterized by the accumulation of TG in the liver (Lee et al 2006) caused by obesity and imbalanced diets such as an excessive high-fat or calories diet (HFD). For that reason, NAFLD is accompanied with abnormal lipid metabolism with down-regulation of fatty acid b-oxidation, lipolysis, and increased lipogenesis (Enjoji et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

2015

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Obesity is associated with chronic diseases such as fatty liver, type 2 diabetes, cardiovascular disease, and severe metabolic syndrome. Obesity causes metabolic impairment including excessive lipid accumulation and fibrosis in the hepatic tissue as well as the increase in oxidative stress. In order to investigate the effect of mulberry leaf (Morus alba L.) extract (MLE) on obesity-induced oxidative stress, lipogenesis, and fibrosis in liver, MLE has been gavaged for 12 weeks in high-fat diet (HFD)-induced obese mice. MLE treatment significantly ameliorated LXRa-mediated lipogenesis and hepatic fibrosis markers such as a-smooth muscle actin, while MLE up-regulated lipolysis-associated markers such as lipoprotein lipase in the HFD-fed mice. Moreover, MLE normalized the activities of antioxidant enzymes including heme oxygenase-1 and glutathione peroxidase in accordance with protein levels of 4-hydroxynonenal in the HFDfed mice. MLE has beneficial effects on obesity-related fatty liver disease by regulation of hepatic lipid metabolism, fibrosis, and antioxidant defense system. MLE supplementation might be a potential therapeutic approach for obesity-related disease including non-alcoholic fatty liver disease.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

2015

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“…It has been reported to have hepatoprotective, anticholestatic, antioxidant, and immune-modulating effects, among others [2][3][4][5]. Picroside II (b-D-glucopyranoside-1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno [4,5]cyclopenta [1,2-c]pyran-2-yl; Fig. 1) is one of the main active constituents.…”

Section: Introductionmentioning

confidence: 99%

Elucidation of the Structures of Metabolites of Picroside II in Rat Bile by LC–ESI–IT–MS

Han

et al. 2011

Chromatographia

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Picroside II is one of the main active constituents of Picrorhiza kurroa, which has hepatoprotective, anticholestatic, antioxidant, and immune-modulating activity. To gain an understanding of the biotransformation of picroside II in vivo, liquid chromatography-electrospray ionization ion-trap mass spectrometry (LC-ESI-IT-MS) was used to investigate the metabolism of picroside II in rats after intravenous administration of a single dose. This method could simultaneously determine picroside II and its metabolites in rat bile. The bile samples were purified by use of a C 18 solid-phase extraction (SPE) cartridge and were separated on a Hypersil ODS2 C 18 analytical column. Two phase II metabolites of picroside II in rat bile were characterized, and elucidation of their structures was performed by comparing changes in molecular masses (DM), retention times, and MS 2 spectral patterns of metabolites with those of the parent drug. Two metabolites identified for the first time in this research were glucuronide and sulfate conjugates.

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“…Liver weight, serum aspartate transferase (AST), alanine transferase (ALT ), low density lipoprotein (LDL), triglyceride and total cholesterol levels were significantly reduced by the treatment. On the contrary, serum HDL level seems not affected by P. kurroa water extract (Lee et al, 2008).…”

Section: Hypolipemic Activitymentioning

confidence: 79%

“…But due to our sedentary lifestyle and dietary habits, our liver gets affected by several diseases like cirrhosis of liver, jaundice, hepatitis B, gall bladder stones, etc. Kutki is mainly known for its hepatoprotective properties, jaundice, bile disorders and other ailments of liver (Lee et al, 2008). …”

Section: Main Uses Of Kutki Is Referred In Liver Diseasesmentioning

confidence: 99%

PicrorhizakurroaRoyle ex Benth. A plant of diverse pharmacological potential

Sultan¹,

Rasool²,

Hassan³

2017

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Amongst many useful herbs, Picrorhiza kurroa Royle ex Benth. is considered a bitter drug, used in treating liver disorders since antiquity. A bitter extract of P. kurroa, rich in iridoid glycosides has hepatoprotective, anticholestatic, antioxidant, anti-inflammatory and immune modulating activities. In an effort to explore possibilities for future use of some useful herbal formulations, often some important herbs are ignored, one such plant is P. kurroa. Thus, an effort has been made in reviewing the available literature about the plant in the most common texts which would provide an insight for the use of this herb against various diseases like disorders of the liver, upper respiratory tract and more recently against hyperlipidemia. Hyperlipidemia mostly contributes to the prevalence and severity of coronary heart diseases and treatment of these diseases using herbal formulations is cheap and easily available. The possible mechanism suggested and proposed for this hypothesis demonstrates that P. kurroa improves gall bladder secretions, thus helping in the digestion and metabolism of fats and it thus becomes very effective in regulating fat metabolism in the liver.

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Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse

Cited by 28 publications

References 31 publications

Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

Elucidation of the Structures of Metabolites of Picroside II in Rat Bile by LC–ESI–IT–MS

PicrorhizakurroaRoyle ex Benth. A plant of diverse pharmacological potential

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