Hypolipidaemic Activity of a Polysaccharide Extract from Fucus vesiculosus L.

Vázquez-Freire, M. J.; Lamela, M.; Calleja, J. M.

doi:10.1002/(sici)1099-1573(199612)10:8<647::aid-ptr931>3.3.co;2-p

Cited by 9 publications

(12 citation statements)

References 10 publications

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“…It is known that for being an effective pharmacological agent, a component should reduced the levels of LDL-cholesterol, because low-density lipoprotein transports 70% of plasma cholesterol in humans. Epidemiological and clinical studies have demonstrated a positive correlation between LDL-cholesterol concentration in serum and the incidence of coronary heart disease (Vazques-Freire et al, 1996). In the present study, a significant decrease in total lipid, triglycerides, cholesterol and LDL-cholesterol levels in I. germanica-treated group of animals was observed as compared to high-fat diet exclusive group.…”

Section: Discussionmentioning

confidence: 99%

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Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet

Choudhary

Naheed

Jalil

et al. 2005

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

“…High-fat diet (HFD) consists of well-mixed (20%) cooking oil and (80%) normal laboratory feed (Vazques-Freire et al, 1996).…”

Section: Animal Dietmentioning

confidence: 99%

Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet

Choudhary

Naheed

Jalil

et al. 2005

Journal of Ethnopharmacology

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“…Both VLDL and LDL are known to have a positive role in atherosclerosis [26,27]. Oxidation of LDL, the major cholesterol carrying protein in blood, is implicated in the initiation as well as progression of atherosclerotic lesions, in coronary heart diseases.…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic Effect of Black Pepper (Piper nigrum Linn.) in Rats Fed High Fat Diet

Vijayakumar

Surya

Rajagopal

et al. 2002

J. Clin. Biochem. Nutr.

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SummaryEffect of administering black pepper (Piper nigrum Linn.), one of the commonly consumed spices and its active principle piperine, to high fat fed rats was studied for a period of 10 weeks. Black pepper at two different doses of 250 mg/kg body weight and 500 mg/kg body weight and piperine at 20 mg/kg body weight were made into a coarse solution with distilled water and administered orally by intragastric intubation daily. The plasma and tissue lipid profile showed a remarkable reduction in the levels of total cholesterol (both the free and ester cholesterol fractions), free fatty acids, phospholipids and triglycerides in black pepper as well as in the piperine treated groups. Moreover, supplementation of the high fat fed rats with black pepper or piperine elevated the concentration of high density lipoprotein-cholesterol and reduced the concentrations of low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol in the plasma as compared with the levels in unsupplemented high fat fed rats. Thus dietary intake of black pepper or piperine was found to reduce the risk of atherosclerosis markedly by virtue of its hypolipidemic and antiatherogenic effects.

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“…The high-fat diet composed of a normal diet (standard commercial diet) supplemented with cholesterol 2 %, sodium chlorate 2 %, vitamin mixture 2%, oligoelements 0.2 %, salt mixture 5.8 %, fat 20 %, cellulose 4 %, sucrose 44%, casein 5 %, and protein 15 % [23], was used to induce weight gain and hyperlipidemia. Male Wistar-EPM-M1 rats were divided into nine groups (6 animals each group): normal diet; normal diet plus THA; normal diet plus orlistat; normal diet plus lovastatin; high-fat diet 4; control group; high-fat diet plus THA; high-fat diet plus orlistat; high-fat diet plus lovastatin.…”

Section: Weight Gain and Chronic Hypolipidemic Assaymentioning

confidence: 99%

The 2′,4′,6′-Trihydroxyacetophenone Isolated fromMyrcia multifloraHas Antiobesity and Mixed Hypolipidemic Effects with the Reduction of Lipid Intestinal Absorption

et al. 2011

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This study evaluated the hypolipidemic and antiobesity effects of phloroacetophenone (2',4',6'-trihydroxyacetophenone, THA) isolated from Myrcia multiflora and their relationship with triglyceride (TG) intestinal absorption and pancreatic lipase activity inhibition. The hypolipidemic effect of THA was evaluated by acute (Triton WR-1339 treatment) and chronic assay (high-fat diet treatment), the antiobesity effect was evaluated by chronic assay (high-fat diet treatment), while the inhibition of enzymatic activity of pancreatic lipase was measured in the intestinal tissue of mice treated with high olive oil concentration. In the acute assay, THA caused greater total cholesterol (37 %) and triglyceride (46 %) serum level reduction than lovastatin (32 and 1 %), a HMG-CoA reductase inhibitor or orlistat (26 and 34 %), a gastrointestinal lipase inhibitor. In addition, in the chronic assay with a high-fat diet, THA reduced cholesterol and triglyceride levels (32 and 61 %, respectively) while lovastatin showed a decrease of 35 and 49 %, respectively. THA also caused a reduction in weight gain very similar to orlistat (40 and 38 %, respectively) when the animals were submitted to a high-fat diet. Moreover, THA showed a stronger and continuous pancreatic lipase inhibitory activity when compared with orlistat, causing inhibition of this enzyme during 6 hours associated to a significant reduction of triglyceride serum levels. The IN VIVO antiobesity and hypolipidemic effects of THA may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.

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Hypolipidaemic Activity of a Polysaccharide Extract from Fucus vesiculosus L.

Cited by 9 publications

References 10 publications

Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet

Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet

Hypolipidemic Effect of Black Pepper (Piper nigrum Linn.) in Rats Fed High Fat Diet

The 2′,4′,6′-Trihydroxyacetophenone Isolated fromMyrcia multifloraHas Antiobesity and Mixed Hypolipidemic Effects with the Reduction of Lipid Intestinal Absorption

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