Hypolipidaemic activity of dimethoxy unconjugated propenyl side-chain analogs of ?-asarone in mice

Synthesis and Hypolipidaemic Evaluation of a Series of α-Asarone Analogues Related to Clofibrate in Mice

“…The alcohol derivatives 3a±3c did not have consistent hypolipidaemic activity, suggesting that the carboxylic group in compounds 2 is involved in their activity. In addition, and in agreement with previous results (Chamorro et al 1998), the hypolipidaemic activity of compounds 2a±2f, which have the unconjugated propenyl group, also suggests that conjugation of the double bond of the side-chain with the aromatic ring is not an important factor in determining the high hypolipidaemic activity shown by a-asarone and some of its 4substituted derivatives .…”

“…Mutagenic (Morales-Ramõ Ârez et al 1992) and teratogenic effects have been also demonstrated in mice. These results prompted us to undertake the synthesis and evaluation of several non-conjugated dimethoxypropenyl derivatives of a-asarone Chamorro et al 1998). Results of experiments with mice revealed hypolipidaemic reduction of lipid levels in the serum, suggesting that the lack of conjugation of the propenyl chain with the aromatic ring does not signi®cantly affect the pharmacological pro®le of these a-asarone analogues.…”

Synthesis of Photosensitive Organic−Inorganic Polymer Hybrids by Utilizing Caged Photoactivatable Alkoxysilane

“…This result is consistent with the previous observations of the spectral changes during photoirradiation of accompanying NVOC-modified compounds. 24,25 Synthesis of Photosensitive Polymer Hybrids Utilizing NVOC-Modified Alkoxysilane. Organicinorganic polymer hybrids of PAA utilizing NVOCmodified alkoxysilane were prepared.…”

“…The compound of allyl-NVOC was prepared according to the detailed experimental procedure described in a previous literature. 25 The compound of NVOC-PTEOS was prepared by the hydrosilylation of allyl-NVOC with triethoxysilane using a platinum catalyst. Under a nitrogen atmosphere, 0.70 g (3.12 mmol) of allyl-NVOC, 1.50 mL (8.13 mmol) of triethoxysilane, and 0.03 mL of the platinum-divinyltetramethyldisiloxane complex (in xylene solution) were dissolved in 2 mL of THF solution, and the mixture was refluxed for 72 h. After evaporation of THF, the oily product was washed using hexane three times under nitrogen.…”

Synthesis and Hypolipidemic Activity of Modified Side Chain α-Asarone Homologues

“…Moreover, in order to evaluate the effect of the double bond conjugation with the aromatic ring as an important pharmacophore upon the activity of 1, 4substituted-1,2-dimethoxy unconjugated propenyl side-chain compounds 5 were prepared [19]. The hypolipidemic decrease of lipids in serum in mice of these analogs suggested that the lack of conjugation of the propenyl chain does not significantly affect the pharmacological profile of these analogs [20]. Recently, a series of derivatives 6 related to the former clinicallyused drug clofibrate, containing an acetic acid moiety on carbon C-2 of the aromatic ring, as acid or methyl and ethyl esters, revealed a potent cholesterol plasma level reduction in hyperlipidemic male mice [21].…”