Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of <i>Hippophae rhamnoides</i>
 L. in mice fed a high-fat diet

Wang, Jiesi; Zhang, Wen; Zhu, Dan; Zhu, Xinglei; Pang, Xiufeng; Qu, Wei

doi:10.1002/jsfa.4331

Cited by 55 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SBT seed oil also caused a significant vasorelaxation (Basu et al, 2007). The hypolipidemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. (FSH) were evaluated in a high-fat diet fed mouse model (Wang et al, 2011). FSH significantly lowered total cholesterol and triglyceride concentrations in liver, and the results were corroborated by transmission electron microscope findings.…”

Section: Cardioprotective and Anti-atherogenic Effectsmentioning

confidence: 87%

Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.)

Suryakumar

Gupta

2011

Journal of Ethnopharmacology

382

250

View full text Add to dashboard Cite

Section: Cardioprotective and Anti-atherogenic Effectsmentioning

confidence: 87%

Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.)

Suryakumar

Gupta

2011

Journal of Ethnopharmacology

382

250

View full text Add to dashboard Cite

“…To produce experimental model of diabetes, 42 male Sprague-Dawley rats were administrated with a modified high fat high sucrose diet (HFHSD; 68.8% standard chow, 20% sucrose, 10% lard, 0.2% cholesterol, and 1% salt mixture; purchased from the Lab Animal Centre of Jilin University, Jilin, China) [22] for 8 weeks followed by the injection of 30 mg/kg streptozotocin (STZ) for 3 days (i.p., once per day) [23]. During the experiment, 5% glucose solution was fed to rats 4 h after STZ injection to prevent hypoglycaemia.…”

Section: Methodsmentioning

confidence: 99%

Studies on the Antidiabetic Activities ofCordyceps militarisExtract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

Dong

Jing

Qin

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Due to substantial morbidity and high complications, diabetes mellitus is considered as the third “killer” in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded. Our present study aims to investigate the antidiabetic activities of Cordyceps militaris on diet-streptozotocin-induced type 2 diabetes mellitus in rats. Diabetic rats were orally administered with water extract or alcohol extract at 0.05 g/kg and 2 g/kg for 3 weeks, and then, the factors levels related to blood glucose, lipid, free radicals, and even nephropathy were determined. Pathological alterations on liver and kidney were examined. Data showed that, similar to metformin, Cordyceps militaris extracts displayed a significant reduction in blood glucose levels by promoting glucose metabolism and strongly suppressed total cholesterol and triglycerides concentration in serum. Cordyceps militaris extracts exhibit antioxidative effects indicated by normalized superoxide dismutase and glutathione peroxidase levels. The inhibitory effects on blood urea nitrogen, creatinine, uric acid, and protein revealed the protection of Cordyceps militaris extracts against diabetic nephropathy, which was confirmed by pathological morphology reversion. Collectively, Cordyceps militaris extract, a safe pharmaceutical agent, presents excellent antidiabetic and antinephropathic activities and thus has great potential as a new source for diabetes treatment.

show abstract

“…Dietary flavonoids also include the anthocyanins cyanidin, delphinidin, malvidin, pelargonidin, peonidin and petunidin together with the flavanones hesperetin and naringenin, the flavones apigenin and luteolin, and the flavonols myricetin, kaempferol, and quercetin (Grotewold, 2006b). Apart from antioxidant activities, food-derived flavonoids were shown to reduce the incidence of atherosclerosis (Terao, 2009), cancer (Clere et al, 2011), cardiovascular diseases (Bojić, 2011), diabetes (Zheng et al, 2011), thrombosis (Phang et al, 2011), inflammation in arthritis (Gonzalez et al, 2011), neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases (Mandel et al, 2011), obesity (Birari et al, 2011), hyperlipidemia (Wang et al, 2011), nerve injury (Jäger and Saaby, 2011) and hypertension (Cassidy et al, 2011). …”

Section: Flavonoids As Nutraceuticalsmentioning

confidence: 99%

Flavonoids: a metabolic network mediating plants adaptation to their real estate

2014

View full text Add to dashboard Cite

From an evolutionary perspective, the emergence of the sophisticated chemical scaffolds of flavonoid molecules represents a key step in the colonization of Earth’s terrestrial environment by vascular plants nearly 500 million years ago. The subsequent evolution of flavonoids through recruitment and modification of ancestors involved in primary metabolism has allowed vascular plants to cope with pathogen invasion and damaging UV light. The functional properties of flavonoids as a unique combination of different classes of compounds vary significantly depending on the demands of their local real estate. Apart from geographical location, the composition of flavonoids is largely dependent on the plant species, their developmental stage, tissue type, subcellular localization, and key ecological influences of both biotic and abiotic origin. Molecular and metabolic cross-talk between flavonoid and other pathways as a result of the re-direction of intermediate molecules have been well investigated. This metabolic plasticity is a key factor in plant adaptive strength and is of paramount importance for early land plants adaptation to their local ecosystems. In human and animal health the biological and pharmacological activities of flavonoids have been investigated in great depth and have shown a wide range of anti-inflammatory, anti-oxidant, anti-microbial, and anti-cancer properties. In this paper we review the application of advanced gene technologies for targeted reprogramming of the flavonoid pathway in plants to understand its molecular functions and explore opportunities for major improvements in forage plants enhancing animal health and production.

show abstract

Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. in mice fed a high-fat diet

Abstract: These results suggest that FSH possesses hypolipidaemic and hypoglycaemic properties in mice fed a high-fat diet and could be developed as a supplement in healthcare foods and drugs.

Cited by 55 publications

References 25 publications

Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.)

Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.)

Studies on the Antidiabetic Activities ofCordyceps militarisExtract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

Flavonoids: a metabolic network mediating plants adaptation to their real estate

Contact Info

Product

Resources

About