Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits

Ram, Alpana; Lauria, P; Gupta, Rajeev; Sharma, Vikas

doi:10.1016/s0378-8741(96)01473-0

Cited by 54 publications

(29 citation statements)

References 6 publications

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“…In the group treated with NM alone the levels of cholesterol, triglycerides, FFA and PL were maintained at near normal which could be due to effective quenching of free radicals by active phytochemicals in NM, such as flavonoids, saponins and cardiac glycosides 30 in conjunction with its antioxidant properties 31 thus reducing membrane lipidperoxidation, and hence decreased release of PL and FFA. The results of this study are in agreement with those of previous studies where it was reported that faecal excretion of cholesterol and PL 32 and decreased activity of lipoprotein lipase 33 are responsible for decreased lipid levels in NM-pretreated rats that were given ISO.…”

Section: Discussionsupporting

confidence: 93%

Effect of Aqueous Extract of Nutmeg on Hyperglycaemia, Hyperlipidaemia and Cardiac Histology Associated with Isoproterenol-induced Myocardial Infarction in Rats

Kareem¹,

Krushna²,

Hussain³

et al. 2009

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 93%

Effect of Aqueous Extract of Nutmeg on Hyperglycaemia, Hyperlipidaemia and Cardiac Histology Associated with Isoproterenol-induced Myocardial Infarction in Rats

Kareem¹,

Krushna²,

Hussain³

et al. 2009

Trop. J. Pharm Res

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“…Though reports on hypolipidemic effects are available, only a single dose of MF has been employed in rabbits (Sharma et al, 1995;Ram et al, 1996). Our decision to explore this possibility was based on the observation that terpenoidtype quinines isolated from the tree Pycnanthus angolensis Welw (Myristicaceae), also known as African nutmeg, have marked antidiabetic effects in mouse models of type 2 diabetes (Luo et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…In some preliminary studies, MF was found to have a hypolipidemic effect in rabbits (Sharma et al, 1995;Ram et al, 1996). However, no reports of detailed investigations of MF are available on the antidiabetic and antihyperlipidemic effects.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antihyperlipidemic Effects ofMyristica fragrans. in Animal Models

Arulmozhi

Kurian

Addepalli

et al. 2007

Pharmaceutical Biology

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The effect of the hydroalcoholic extract of fruits of Myristica fragrans Houtt. (Myristicaceae) was investigated on chlorpromazine-induced glucose and triglyceride elevations in male Swiss albino mice. After 7 days of oral administration, the extract, at doses of 150 and 450 mg=kg, ameliorated the metabolic abnormalities caused by chlorpromazine as evidenced by significant reduction of glucose and triglyceride (TG) levels (maximal effect of 41% and 53% reduction of glucose and TG, respectively, at 450 mg dose, p < 0.01). The standard antidiabetic rosiglitazone at 10 mg significantly (p < 0.01) reduced the TG (63%) and glucose (40%) levels in this model, while the standard antidiabetic glimepiride has exhibited 55% and 16% reduction in TG and glucose, respectively. In rats fed a high-cholesterol diet, Myristica fragrans extract significantly reduced the elevated TG (47% reduction at 450 mg, p < 0.01) and cholesterol (66.7% reduction at 450 mg, p < 0.01), and also exhibited a reduction in hepatic TG secretion after tyloxapol administration. These data suggest that Myristica fragrans extract ameliorates hyperglycemia and abnormal lipid metabolism in animal models.

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“…500 mg/kg of the extract administered per day for 60 days in the hyperlipidemic rabbits resulted in significantly lower levels of lipoprotein lipids. [73] …”

Section: Hypolipidemic Activitymentioning

confidence: 99%

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Hamiduddin¹

2018

IJGP

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Jaiphal is a common fruit of Myristica fragrans Houtt. plant used as spices as well as for medicinal purpose in Unani System of Medicine since antiquity. The Saydalaneh (pharmacist) in Arab introduce a large number of new drugs to clinical use including nutmeg. As a Unani concept of temperament, it is hot and dry. It is very common and popular drug used as digestive, carminative, appetizer, exhilarant and mood elevator, antitussive, antiemetic, demulcent, aphrodisiac, stomachic, liver, nervine, cardio, and uterine tonic in Unani System of Medicine. Extensive information is provided in Unani text by Greek physicians about this drug so it is used in many compound formulations and useful recipes. These importance and benefits lead to further review to explore its medicinal importance. Review reveals digestive, appetizer, exhilarant and mood elevator, antitussive, antiemetic, nervine tonic, aphrodisiac, antidiarrheal, liver tonic, cardiotonic, and uterine tonic. Recent researchers indicate antimicrobial, hypolipidemic, antioxidant, anticancer, sedative, analgesic, and anti-inflammatory activity. Further, scope of research can also be explored with the help of traditional knowledge exist in Unani and other traditional medicine.

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Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits

Cited by 54 publications

References 6 publications

Effect of Aqueous Extract of Nutmeg on Hyperglycaemia, Hyperlipidaemia and Cardiac Histology Associated with Isoproterenol-induced Myocardial Infarction in Rats

Effect of Aqueous Extract of Nutmeg on Hyperglycaemia, Hyperlipidaemia and Cardiac Histology Associated with Isoproterenol-induced Myocardial Infarction in Rats

Antidiabetic and Antihyperlipidemic Effects ofMyristica fragrans. in Animal Models

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