Hypolipidemic activity of Lannea coromandelica Houtt. leaves in Triton X-100 induced hyperlipidemic rats

Abstract

Lannea coromandelica Houtt have multiple pharmacological activities including anti-inflammatory, aphrodisiac hypotensive, anti microbial, ulcerative stomatitis, wound healing, leprosy, gout, elephantiasis and cholera. Therefore, the present study is taken up to evaluate the hypolipidemic activity of ethanolic leaf extract of L.coromandelica. The ethanolic leaf extract was evaluated for its acute toxicity (2000mg/kg) and for hypolipidemic activity (100 and 200 mg/kg) in Triton X-100 (100mg/kg, i.p) induced model for 7 days. However, the obtained statistical data indicated a significant decrease in the total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and increase in the HDL cholesterol, with reference to the standard drug Atorvastatin (10mg/kg,p.o). These results revealed that L. coromandelica has beneficial effect in reducing the blood lipid levels indicating its efficient hypolipidemic activity.

Phytochemistry and Pharmacological Bio-Activities of Lannea Coromandelica: A Review

“…The petroleum crude ether extract solely includes steroids and triterpenes. Terpenes, carbohydrates, glycosides, alkaloids, flavonoids, fats, oils, waxes, and tannins were found in the leaf's extracts of L. coromandelica including 4'-methoxymyricetin 3-O-α-L-rhamnopyranoside, myricetin (3-O-α-L-rh), amnopyranoside, myricetin 3-O-β-D-glucopyranoside, vitexin, isovitexin, gallic acid, and epicatechin have been considered as major components leaf extract of Lannea macrocarpa [46][47][48].…”