Hypolipidemic and anti‐atherogenic activities of crude polysaccharides from abalone viscera

Abstract

This study was performed to evaluate the hypolipidemic and anti‐atherogenic activities of the crude polysaccharides extracted from abalone viscera (AVCP). The major functional groups of purified polysaccharides were analyzed by infrared spectroscopy (IR). Male Kunming mice (SPF) were divided into six groups and were treated with normal diet or high‐fat diet with AVCP or Xuezhikang (hypotensive drug) for 5 weeks. Physicochemnical analysis of AVCP showed the presence of 60.4% polysaccharides, 17.9% protein, 6.0% fat and 10.9% moisture. The IR analysis of AVP showed the presence of functional groups of sugar moiety and sulfate groups. The results demonstrated that AVCP not only led to significant reduction of total cholesterol (TC), triglycerides (TG), low‐density lipoprotein cholesterol (LDL‐C), and increase of high‐density lipoprotein cholesterol (HDL‐C) in plasma, but also to significant increments of malondialdehyde (MDA) and superoxide dismutase (SOD) activities. However, AVCP played no role in mice weight. Furthermore, the results of the photomicrograph of liver tissue showed that AVCP reduced lipid droplets and prevented the disordered structure of the liver. The results suggested that AVCP exhibited significantly hypolipidemic and anti‐atherogenic activities.

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

“…MSP from Cystoseira crinita could inhibit lipase activity in plasma and small intestine, leading to a significant decrease in blood triglyceride in rats fed a high fat diet [51]. In mice induced by high fat diet, it was found that polysaccharides from abalone viscera not only decreased blood lipid but also significantly increased the activity of malondialdehyde and superoxide dismutase, suggesting that it might play a role in the antioxidant pathway to improve the lipid metabolism disorder [52]. Ethanol extract from Hypnea musciformis could modulate lipid peroxidation in mammary carcinogenesis [53].…”

“…A fraction named AGP33 with sulfates occur at 3-O-and 4-O-positions showed a better anticoagulant activity than its desulfated product [93]. MSPs from abalone viscera also exhibited significantly hypolipidemic and anti-atherogenic activities [52]. Another abalone SP (AGSP) and its desulfated product D-AGSP can inhibit fat accumulation and improve lipid metabolism balance and gut microbiota dysbiosis in mice fed with high fat diet [94].…”

Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high‐cholesterol diet‐fed zebrafish

“…Numerous studies have demonstrated, large amounts of bioactive compounds like polysaccharides extracted from natural resources can ameliorate lipid metabolic disorders due to their high efficacy against hyperlipidemia and their little or none adverse side effects (L. Li & W. Guo et al., 2019 ; Xie et al., 2016 ). Crude polysaccharides extracted from abalone viscera reduce lipid levels in plasma and show antiatherogenic activity in a mouse model of a lipid disorder (Liu et al., 2020 ). The sulfated polysaccharides from Cytosmear crinite induced a decrease in low‐density lipoprotein (LDL) and triglycerides (TG) and an increase in high‐density lipoprotein (HDL) blood levels in high‐fat diet rats (Ben Gara et al., 2016 ).…”

Immunomodulatory effects of the polysaccharide from Sinonovacula constricta on RAW264.7 macrophage cells

“…anti-atherogenic, antitumor, antiviral, and immunomodulation activities (Ferreira et al, 2015;Martins et al, 2017;Liu et al, 2020).…”