Hypolipidemic and Anti‐Obesity Effects of Hydroalcoholic Extract of Brazilian Red Propolis in a Rodent Model of Dyslipidemia

Abstract

The widespread use of Brazilian red propolis extract promotes an increased production rate in the Northeast region of Brazil, with an impressive economic turnover for the region. The rational use of the hydroalcoholic extract of red propolis (HERP) raises the question about its value against obesity. In this work, the aim is to evaluate the anti-obesity effect of HERP in rats submitted to hyperlipid dietary (HLD) supplementation. HERP extraction yield is 17.46% (m/v). The major chemical components of HERP are found to be daidzein (4.16 ± 0.22 mg g −1 ), formononetin (9.21 ± 0.10 mg g −1 ), and biochanin A (7.08 ± 0.09 mg g −1 ). After 8 weeks, the animals under HLD supplementation show significantly greater body weight gain, while after the subsequent 4-week treatment with HERP, HLD-HERP animal shows lower body weight gain than HLD-vehicle animals. Oral administration of HERP also attenuates the pathological changes in the liver, kidney, and large intestine caused by HLD supplementation. This study demonstrates that HERP treatment has a hypolipidemic effect in a rodent model of dyslipidemia and that HERP minimizes the impact of a hyperlipidic diet on murine body weight parameters and abdominal fat accumulation. Practical Applications: Brazilian red propolis is being exploited for a range of biomedical applications. It is demonstrated that its extract has hypolipidemic effect in a rodent model of dyslipidemia and minimizes the impact of a hyperlipidic diet on murine body weight parameters and abdominal fat accumulation.

Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: in vivo study and in silico prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites

“…Similar findings were reported in earlier research on the effect of natural products and extracts on lipid metabolism. 46,47…”

“…Similar findings were reported in earlier research on the effect of natural products and extracts on lipid metabolism. 46,47 Besides, it is actually known that hypertriglyceridemia is closely related to an increase in body weight, liver steatosis, and abdominal obesity, which lead to insulin resistance and then hyperglycemia, constituting the onset of diabetes mellitus and CVD. 47,48 Our research showed that the Triton WR-1339 injection increased body weight, visceral adipose tissue mass, triglyceridemia, glycemia and liver lipid content; this is in accordance with previous studies.…”

Chemical constituents, free radical scavenging and enzyme inhibitory potential of selected Nigerian bee (Apis mellifera) propolis

“…Hydroalcholic extract of Brazilian red propolis had been reported to effect a hypolipidemic change in a rodent model of dyslipidemia. The extract minimised the effect of a hyperlipidic diet on murine body weight parameters and abdominal fat accumulation (Prata et al, 2022).…”

Anti-Obesity Effect of Combining White Kidney Bean Extract, Propolis Ethanolic Extract and CrPi3 on Sprague-Dawley Rats Fed a High-Fat Diet

“…Research on rat models of diabetes or dyslipidemia has documented the hypolipidemic and lipid peroxidation effects of PEE [ 79 , 80 , 81 ]. Propolis’s ability to inhibit the synthesis of cholesterol by lowering the level of β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase protein in the liver has been identified as its mechanism of action [ 82 ].…”