Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed

Lim, Dong-Hoon; Choi, DuBok; Kim, Sunmi; Piao, Yulan; Choi, On-You; Lim, Geum-Sook; Chang, Young-Cheol; Cho, Hoon

doi:10.1007/s11814-016-0335-8

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…This result suggested that SADE exerts its anti-dyslipidemic effect (hypocholesterolemic and hypotriglyceridemic) on the HCD group. Similar studies reported the anti-hyperlipidemic effect of the S. bigelovii seed polysaccharide extract at 200 mg/kg body weight/day in hyper-cholesterol-fed rats [ 23 ]. Thus, in this study, it seems that SADE could have the capability to regulate lipid metabolism and the potential to reduce cardiovascular complications.…”

Section: Resultsmentioning

confidence: 56%

“…S. arabica is not well investigated for its therapeutic use. Several species of Salicornia , such as S. herbacea , S. bigelovii, and Sarcocornia perennis , have been reported as presenting beneficial effects in vitro and in vivo, including antioxidant activity [ 25 , 43 ], hypolipidemic [ 23 , 64 ], anti-obesity [ 24 , 36 ], and immunomodulatory effects [ 65 ]. SADE resulted in rapid restoration of TC ( Figure 5 a), TG ( Figure 5 b), and LDL levels ( Figure 5 d).…”

Section: Resultsmentioning

confidence: 99%

“…Salicornia genus has recently been commercialized in Europe and Asia as a staple food, and it is used in green salads for its saltiness [ 20 ] or as an ingredient in various recipes as tea powder, seasoned vegetable, makgeolli, pickled vegetables, vinegar and fermented food [ 21 ]. Various promoting therapeutic applications have been reported for Salicornia species: Salicornia herbacea and Salicornia bigelovii are in particular used against oxidative stress, inflammation gastroenteritis, cancer, diabetes, asthma and hepatitis [ 21 ] and in the treatment of various diseases such as obesity, hyperglycemia and hyperlipidemia [ 22 , 23 ]. Salicornia herbacea supplementation reduces fat accumulation in the liver and regulates hepatic triglycerides [ 24 ], decreases lead-induced oxidative stress, and exerts cytoprotective action [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Chrigui

Taieb

Jemai

et al. 2023

Foods

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Salicornia is a halophyte plant that has been used in traditional medicine for the treatment of scurvy, goiter, and hypertension. It is commercialized in Europe and Asia as fresh salads, pickled vegetables, green salt, or tea powder. This work is the first to assess the potential anti-obesity and anti-dyslipidemic effects of Salicornia arabica decocted extract (SADE). SADE was characterized by its significant in vitro radical scavenging activity (using DPPH and ABTS assays). The effect of SADE on food intake, weight loss, serum biochemical parameters, liver and kidney weights, adiposity index and on liver histology was investigated in the Tunisian gerbil Psammomys obesus (P. obesus), which is recognized as a relevant animal model of human obesity and diabetes. P. obesus animals were firstly randomly divided into two groups: the first received a natural low-calorie chow diet (LCD), and the second group received a high-calorie diet (HCD) over 12 weeks. On day 90, animals were divided into four groups receiving or not receiving SADE (LCD, LCD + SADE, HCD, and HCD + SADE). If compared to the HCD group, SADE oral administration (300 mg/kg per day during 4 weeks) in HCD + SADE group showed on day 120 a significant decrease in body weight (−34%), blood glucose (−47.85%), serum levels of total cholesterol (−54.92%), LDL cholesterol (−60%), triglycerides (−48.03%), and of the levels of hepatic enzymes: ASAT (−66.28%) and ALAT (−31.87%). Oral administration of SADE restored the relative liver weight and adiposity index and significantly limited HCD-induced hepatic injury in P. obesus. SADE seems to have promising in vivo anti-obesity and anti-dyslipidemic effects.

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Section: Resultsmentioning

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Chrigui

Taieb

Jemai

et al. 2023

Foods

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“…& Bayoumi, 1997;Belal & Al-Dosari, 1999;E. P. Glenn et al, 2012;Kim, 2017;Kraidees, Abouheif, Al-Saiady, Tag-Eldin, & Metwally, 1998;Lim et al, 2017;Manousaki & Kalogerakis, 2011;Slama, Abdelly, Bouchereau, Flowers, & Savouré, 2015;Ventura et al, 2011;Warshay, Pan, & Sgouridis, 2011). El contenido de proteína, fibra y cenizas totales por hectárea se ha reportado entre los 30-40%, 4.5-8% y 5.5-8.5% respectivamente (Anwar, Bhanger, Nasir, & Ismail, 2002;Burboa et al, 2017;E.…”

Section: Núm 49: 75-92unclassified

Ecofisiología y bioquímica de Salicornia bigelovii (Torr.) Por efecto de quitosano-aib bajo condiciones del desierto de Sonora

et al. 2020

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“…Similarly, Salicornia seeds are rich in nutrients and varied minerals such as potassium, sucrose, glycerol, oleic and linoleic unsaturated fatty acids [12], and used as tea material [13]. Experimentally, it has been demonstrated that Salicornia herbacea and Salicornia bigelovii seed extract exhibit antitumor, antioxidant, antibacterial and hypolipidemic activity [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury

Ferreira

Pinto

Silva

et al. 2018

Biomedicine & Pharmacotherapy

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The growing importance of Salicornia plants as bioactive agents and health promoters associated with the continuous demand for alternative treatments for liver disorders, has stimulated us to evaluate the renal and hepatic effects of S. ramosissima seeds in mice under normal conditions and exposure to toxic products as carbon tetrachloride (CCl). Thus, histopathological and lipid peroxidation evaluations of the liver and kidneys were performed. Powdered dried seeds of S. ramosissima (SRS) were administered orally for 22 days at a dose of 2000 mg/kg/day to male mice in three different settings: 1) seed effects, 2) protection against CCl acute toxicity (0.2 mL/kg) and 3) regeneration after acute exposure to CCl (0.2 mL/kg), each study being performed with appropriate control animals. Mice treated with SRS per se had slightly enlarged hepatic sinusoids and noticeable renal inflammation. SRS did not show effective protection against mice exposed to CCl and had no positive influence on liver and kidney recovery after CCl administration. These results demonstrated that SRS failed to improve hepato- and nephrotoxicity, in addition to the apparent synergism between CCl and SRS under these experimental conditions. Although the biological mechanisms of S. ramosissima are not fully understood, the evidence suggests further research to elucidate its adverse biological effects.

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Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed

Cited by 7 publications

References 29 publications

Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Ecofisiología y bioquímica de Salicornia bigelovii (Torr.) Por efecto de quitosano-aib bajo condiciones del desierto de Sonora

Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury

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