Hypolipidemic and antioxidant efficacy of giant embryo brown rice in high-fat-fed guinea pigs

Abstract

To investigate the antihyperlipidemic effects of giant embryo rice 'Shangshida No. 5' on high-fat-fed guinea pigs, fortyeight male guinea pigs were randomly assigned and fed the following diets for 12 weeks: normal control (NC), normal control supplemented with giant embryo brown rice (NC-GB), high fat (HF), and high-fat supplemented with giant embryo brown rice (HF-GB). The body weights, lipid profiles, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and liver cellular structures were monitored. The results showed that the HF guinea pigs exhibited significantly (P<0.05) higher levels of plasma triglyceride, total cholesterol, low-density lipoprotein cholesterol, and hepatic triglyceride than NC group. However, diet supplementation with giant embryo brown rice partially counteracted the high fat-induced hyperlipidemia. In addition, diet supplementation with giant embryo brown rice markedly enhanced plasma SOD activities, reduced MDA levels and alleviated liver cellular structures damage in high-fat-fed guinea pigs (P<0.05). Besides, 'Shangshida No. 5' is enriched in trace elements, unsaturated fatty acids, dietary fiber, total protein, and total lipids compared with control rice 'Chao2-10'. These findings illustrated that 'Shangshida No. 5' is useful as a functional food because of its hypolipidemic effects and antioxidant activity.